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Scheme : Research Fellowships
Research Topic : genetic regulation
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  • Funded Activity

    Research Fellowship

    Funder
    National Health and Medical Research Council
    Funding Amount
    $777,795.00
    Summary
    As a molecular geneticist, I am interested in how and why genetic mutations occur, how these changes cause disease or disease predisposition, and ways of better treating and monitoring genetic disease. The ‘model diseases’ I am most interested in are blood cell diseases such as autoimmunity (e.g. arthritis) and leukaemias.
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    Funded Activity

    High-Throughout Identification And Targeting Of New Breast Cancer Genes.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $640,210.00
    Summary
    Recent studies have identified DNA sequence variations within the human genome that are associated with an increased risk or can influence the outcome of breast cancer. This research program will identify the key genes affecting cancer development and assess their contribution to cancer growth. I will then use this knowledge to assess their suitability for drug development. Understanding how our DNA contributes to breast cancer will provide new avenues for prevention or treatment.
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    Funded Activity

    Applying Next Generation Sequencing To Family Studies

    Funder
    National Health and Medical Research Council
    Funding Amount
    $182,622.00
    Summary
    Recent advances in technology can determine the DNA composition of a person for much longer stretches of DNA, at a much cheaper cost. I use statistical analysis to identify regions of the human genome that harbour mutations that cause diseases such as epilepsy in families. These regions contain 5-15 million base pairs. We need to find the ONE base pair that causes disease. This application deals with the development of new tools to exploit new technology for the identification of mutations.
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    Funded Activity

    Neurogenetics And Statistical Genomics

    Funder
    National Health and Medical Research Council
    Funding Amount
    $923,684.00
    Summary
    We recently established the Centre for Neurogenetics and Statistical Genomics, a research centre within the Queensland Brain Institute. It was established to bring together a team of researchers with expertise in neurogenetics, neuropsychiatric genetics, statistical genomics and computational biology. During my Fellowship I will conduct research at this Centre to elucidate the genetic basis of neurogenetic diseases and psychiatric disorders, using genomic tools and data analysis.
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    Funded Activity

    Developing And Applying Statistical Genetics Methods To Identify Genes, Molecular Biomarkers And Environmental Agents That Causally Affect Risk Of Complex Musculoskeletal Diseases

    Funder
    National Health and Medical Research Council
    Funding Amount
    $707,370.00
    Summary
    My aim is to identify genes, biological molecules and environmental factors that causally affect risk of osteoporosis and ankylosing spondylitis (a form of autoimmune arthritis) using novel and existing statistical genetics methodologies. My research will advance understanding of the causes of these diseases, identify new opportunities for their treatment, and provide the scientific community with new statistical methods and software to identify factors that causally influence risk of disease.
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    Funded Activity

    Research Fellowship

    Funder
    National Health and Medical Research Council
    Funding Amount
    $611,574.00
    Summary
    I am a genetic epidemiologist focused on bowel cancer risk. I will develop a comprehensive model to estimate individual cancer risk by studying the effects of personal characteristics, cancer history, genetic factors and family history of cancer using large data sets from international consortia I helped establish. My research will enable targeting of screening to those most at risk and will aid the discovery of new causes for bowel cancer.
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    Funded Activity

    Translation Of Genetic Findings Into Improved Health Outcomes For Common Eye Diseases In Our Society

    Funder
    National Health and Medical Research Council
    Funding Amount
    $675,736.00
    Summary
    Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patie .... Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patients.
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    Funded Activity

    Improving Weight Loss Outcomes By Minimizing Adaptive Responses To Energy Restriction

    Funder
    National Health and Medical Research Council
    Funding Amount
    $621,458.00
    Summary
    While losing excess weight reduces the risk of lifestyle diseases such as diabetes, current weight loss strategies are ineffective for most, in part because the body mounts a ‘famine reaction’ that increases hunger, decreases metabolic rate and may also cause loss of muscle and bone mass. This research aims to determine the effects of the famine reaction on body composition, as well as to identify new ways to block the famine reaction with food, thereby enabling more people to attain and maintai .... While losing excess weight reduces the risk of lifestyle diseases such as diabetes, current weight loss strategies are ineffective for most, in part because the body mounts a ‘famine reaction’ that increases hunger, decreases metabolic rate and may also cause loss of muscle and bone mass. This research aims to determine the effects of the famine reaction on body composition, as well as to identify new ways to block the famine reaction with food, thereby enabling more people to attain and maintain a healthy body weight and composition.
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    More information
    Funded Activity

    Research Fellowship

    Funder
    National Health and Medical Research Council
    Funding Amount
    $675,736.00
    Summary
    I am a cancer biologist determining the mechanisms controlling growth and proliferation of cancer cells and use transgenic models of malignancy and genetic approaches to identify new therapies for targeting growth control in the treatment of cancer.
    More information
    Funded Activity

    Research Fellowship

    Funder
    National Health and Medical Research Council
    Funding Amount
    $984,801.00
    Summary
    I work on mitochondrial diseases, which are inherited disorders of metabolism that block conversion of food energy into chemical energy needed by our cells. We focus on understanding (i) the genetic basis of these disorders using approaches such as massively parallel sequencing, systems biology and experimental studies, and (ii) the detailed mechanisms of disease by studying cell lines from patients and animal models. We aim to develop better methods for diagnosis, treatment and prevention.
    More information

    Showing 1-10 of 67 Funded Activites

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