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Australian Laureate Fellowships - Grant ID: FL180100072
Funder
Australian Research Council
Funding Amount
$3,460,832.00
Summary
Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances ....Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances in genomic technologies, to build and sustain critical capacity in statistical genetics, and better understand the causes and consequence of individual differences in human traits from genetic and environmental factors across the entire human lifespan.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100068
Funder
Australian Research Council
Funding Amount
$3,328,974.00
Summary
Australian wild animals: environmental change and quantitative genomics. This project aims to determine the effects of changing environments on wild animal populations across Australia. By combining recent advances in genomic technology with a consortium of fourteen long-term studies of mammals, birds and reptiles, it aims to quantify the genetic basis of life-history variation and the potential for evolutionary adaptation in the wild. The project will generate a comprehensive understanding of t ....Australian wild animals: environmental change and quantitative genomics. This project aims to determine the effects of changing environments on wild animal populations across Australia. By combining recent advances in genomic technology with a consortium of fourteen long-term studies of mammals, birds and reptiles, it aims to quantify the genetic basis of life-history variation and the potential for evolutionary adaptation in the wild. The project will generate a comprehensive understanding of the genetic consequences of environmental change, population decline, inbreeding and disease in natural environments. The expected benefits include a coordinated network for long-term wild animal studies in Australia, advanced quantitative skills training, and knowledge transfer for wildlife management and conservation.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100260
Funder
Australian Research Council
Funding Amount
$2,775,898.00
Summary
Using ancient microbiomes and genomes to reconstruct human history. Using ancient microbiomes and genomes to reconstruct human history. This project aims to generate unique insights into the processes and history that produced the current distribution of modern humans and the bacteria we carry with us (our microbiome). The project will use combined signals of bacterial, genomic and climate data to reconstruct the impacts of migrations, changes in diet, environment, and health in different parts ....Using ancient microbiomes and genomes to reconstruct human history. Using ancient microbiomes and genomes to reconstruct human history. This project aims to generate unique insights into the processes and history that produced the current distribution of modern humans and the bacteria we carry with us (our microbiome). The project will use combined signals of bacterial, genomic and climate data to reconstruct the impacts of migrations, changes in diet, environment, and health in different parts of the world. A key aspect will be the creation of a program to map the genetic history of indigenous Australia, and the impacts of colonisation on indigenous people around the world. Research advances will be transferred to Early Career Researchers through an innovative program of workshops, and the resulting data will be used to create a new format for Australian genetic databases.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100137
Funder
Australian Research Council
Funding Amount
$3,320,000.00
Summary
10,000 Hours: Time in early education and care for better life opportunity. An Australian child spends up to 10,000 hours in early care and education programs prior to school. These hours are a developmental opportunity. Their potential to improve life chances is well documented. Yet many programs do not deliver on this promise. Nearly 1 in 4 Australian children enter school developmentally vulnerable. This study aims to interrogate the meaning of quality in early education and care programs wit ....10,000 Hours: Time in early education and care for better life opportunity. An Australian child spends up to 10,000 hours in early care and education programs prior to school. These hours are a developmental opportunity. Their potential to improve life chances is well documented. Yet many programs do not deliver on this promise. Nearly 1 in 4 Australian children enter school developmentally vulnerable. This study aims to interrogate the meaning of quality in early education and care programs with focus in communities experiencing the greatest challenges. The expected result is understanding of the mechanisms that limit delivery of the highest quality learning opportunities and outcomes for children. The benefit will be for children attending early education and care programs, their families and the nation’s future.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100036
Funder
Australian Research Council
Funding Amount
$3,011,916.00
Summary
Engineering microbes that increase coral climate resilience. This project aims to develop microbes which are able to enhance the climate resilience of corals. Coral reefs around the world are being lost at an alarming rate. Developing microbial symbionts to enhance coral climate resilience will give Australian and other coral reef ecosystems an increased chance of surviving the impact of climate change. The project will also enhance understanding of the functional roles of microbial symbionts of ....Engineering microbes that increase coral climate resilience. This project aims to develop microbes which are able to enhance the climate resilience of corals. Coral reefs around the world are being lost at an alarming rate. Developing microbial symbionts to enhance coral climate resilience will give Australian and other coral reef ecosystems an increased chance of surviving the impact of climate change. The project will also enhance understanding of the functional roles of microbial symbionts of corals, and advance the microbial symbiosis discipline globally. Expected outcomes include healthier coral reefs through the use of more climate resilient coral stock in reef conservation and restoration initiatives.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL100100183
Funder
Australian Research Council
Funding Amount
$2,168,370.00
Summary
Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virule ....Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virulent strains of human, animal or plant diseases, require such evolutionary thinking. Cutting-edge mathematical tools also prepare Australians for an era in the near future where genomic data are so cheap to acquire that training in complex mathematical and logical analysis becomes a factor limiting scientific progress.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100131
Funder
Australian Research Council
Funding Amount
$2,496,651.00
Summary
Geoengineering the Southern Ocean? A transdisciplinary assessment. Geoengineering the Southern Ocean? A transdisciplinary assessment. The project aims to comprehensively evaluate the feasibility of offsetting climate change by using geoengineering to boost carbon dioxide removal by Southern Ocean microbes. With existing polar datasets as a platform, the project would combine experiments and modelling to quantify carbon dioxide removal and critically assess the economic feasibility and side effec ....Geoengineering the Southern Ocean? A transdisciplinary assessment. Geoengineering the Southern Ocean? A transdisciplinary assessment. The project aims to comprehensively evaluate the feasibility of offsetting climate change by using geoengineering to boost carbon dioxide removal by Southern Ocean microbes. With existing polar datasets as a platform, the project would combine experiments and modelling to quantify carbon dioxide removal and critically assess the economic feasibility and side effects of geoengineering. Anticipated outcomes include a framework for governance of future research and informed national/international policy on using geoengineering to mitigate climate change.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100133
Funder
Australian Research Council
Funding Amount
$3,358,494.00
Summary
Activating blue carbon for coastal restoration. Coastal blue carbon describes the carbon stored in soils and biomass of coastal wetlands which has an important function in regulating greenhouse gases. They also provide coastal protection, habitat for biodiversity, fisheries and amelioration of land-based pollution. Coastal wetlands have been degraded globally, reducing their capacity to store carbon and to support coastal communities and their economies. This Fellowship aims to assess how restor ....Activating blue carbon for coastal restoration. Coastal blue carbon describes the carbon stored in soils and biomass of coastal wetlands which has an important function in regulating greenhouse gases. They also provide coastal protection, habitat for biodiversity, fisheries and amelioration of land-based pollution. Coastal wetlands have been degraded globally, reducing their capacity to store carbon and to support coastal communities and their economies. This Fellowship aims to assess how restoration of coastal wetlands influences carbon storage and greenhouse gas fluxes, develop new methodologies and to generate new research capacity to inform coastal wetland management globally. The proposed research is expected to enhance coastal sustainability to the benefit of coastal communities.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100103
Funder
Australian Research Council
Funding Amount
$2,968,718.00
Summary
Interpreting the molecular record in extraordinarily preserved fossils. This project aims to unlock a hidden record of our planet’s past and the life it supported, using a novel approach with benefits for environment and industry. Soft tissues preserved in sedimentary concretion fossils will be analysed, extending the traditional inorganic fossil framework of major evolutionary events. Understanding the biofilm entombment and preservation mechanisms responsible for this unique organic fossil arc ....Interpreting the molecular record in extraordinarily preserved fossils. This project aims to unlock a hidden record of our planet’s past and the life it supported, using a novel approach with benefits for environment and industry. Soft tissues preserved in sedimentary concretion fossils will be analysed, extending the traditional inorganic fossil framework of major evolutionary events. Understanding the biofilm entombment and preservation mechanisms responsible for this unique organic fossil archive will extend our knowledge of microbial functionality. Expected outcomes from this new way of interpreting our planet’s past, include improved understanding of extinction events, environmental change and adaptation, with potential benefits in ecosystem management, resource exploration and biofilm uses.Read moreRead less