Protein Prenylation And Inflammation: New Insights Into The Pathophysiology And Treatment Of Mevalonate Kinase Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$715,755.00
Summary
This project is focused on a genetic, potentially fatal, inflammatory disease that appears in infancy. We have developed a new way of detecting the underlying defect as well as the first animal models that have the same genetic mutations and mimic the disease. With these revolutionary new approaches, we will discover the exact cause of the inflammation, test a new way of diagnosing the disease, and identify new and better therapies that treat the underlying cause rather than just the symptoms.
All cells in the body need to get their energy from somewhere, and the chemical basis of their energy supply varies depends on many factors, including their location and rate of cell division. We have found that an important population of white blood cells that control the character and magnitude of most immune responses appear to use an unusual source of their energy. If true this would provide a range of new opportunities to control the numbers and activities of these cells, a thereby control ....All cells in the body need to get their energy from somewhere, and the chemical basis of their energy supply varies depends on many factors, including their location and rate of cell division. We have found that an important population of white blood cells that control the character and magnitude of most immune responses appear to use an unusual source of their energy. If true this would provide a range of new opportunities to control the numbers and activities of these cells, a thereby control the character and magnitude of immune responses.Read moreRead less