Whole-genome multivariate reaction norm model for complex traits. This project aims to develop a multivariate whole-genome genotype-covariate correlation and interaction model that can be applied to a wide range of existing genome-wide association study (GWAS) datasets. Genotype-covariate correlation and interaction (GCCI) are fundamental in biology but there is no standard approach to disentangle interaction from correlation in the whole-genome analyses. This project will address the key featur ....Whole-genome multivariate reaction norm model for complex traits. This project aims to develop a multivariate whole-genome genotype-covariate correlation and interaction model that can be applied to a wide range of existing genome-wide association study (GWAS) datasets. Genotype-covariate correlation and interaction (GCCI) are fundamental in biology but there is no standard approach to disentangle interaction from correlation in the whole-genome analyses. This project will address the key feature in biology, which relates to dissecting the complex mechanism of association and interaction. The proposed statistical model implemented in a context of a novel design based on multiple GWAS data sets is a paradigm shifting-tool with applications to multiple industries.Read moreRead less
Marsupial genomics: antimicrobial peptides and endangered species conservation. This project aims to use Australia’s unique biodiversity to tackle the global challenge of antimicrobial resistance. Rapid gene duplication and evolution of antimicrobial peptide genes in marsupials provide protection for joeys that are immunologically naïve in the pouch. By characterising immune genes in 10 marsupial species, this project will yield new antimicrobial peptides that can tackle superbugs. Genomic infor ....Marsupial genomics: antimicrobial peptides and endangered species conservation. This project aims to use Australia’s unique biodiversity to tackle the global challenge of antimicrobial resistance. Rapid gene duplication and evolution of antimicrobial peptide genes in marsupials provide protection for joeys that are immunologically naïve in the pouch. By characterising immune genes in 10 marsupial species, this project will yield new antimicrobial peptides that can tackle superbugs. Genomic information will also be used to provide significant benefits, such as improving the long term conservation of our endangered native species in a more appropriate and cost-effective way.Read moreRead less