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Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989804
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A Universal Nano Tribometer for Surface and Thin Film Characterisation. The proposed infrastructure will be of major benefit to a large number of ARC funded research projects involving chracterisation of materials at four universities UOW,QUT, UNSW and CDU. The project will extend the research capability of the participating researchers and facilitate innovative projects and new research direction in advanced materials processing in the nano/micro scale. This in turn will lead to improved intern ....A Universal Nano Tribometer for Surface and Thin Film Characterisation. The proposed infrastructure will be of major benefit to a large number of ARC funded research projects involving chracterisation of materials at four universities UOW,QUT, UNSW and CDU. The project will extend the research capability of the participating researchers and facilitate innovative projects and new research direction in advanced materials processing in the nano/micro scale. This in turn will lead to improved international competitiveness of Australian industry.Read moreRead less
Adverse effects of sopite syndrome on occupants in wind-excited buildings. Current building motion design guidelines focus primarily on motion perception and complaint rates. However, wind-induced building motion can cause sopite syndrome or early onset motion sickness which adversely affects occupant wellbeing and work performance. This research aims to advance the understanding of the physiology of sopite syndrome, quantify the motion dosage that causes sopite syndrome and determine its advers ....Adverse effects of sopite syndrome on occupants in wind-excited buildings. Current building motion design guidelines focus primarily on motion perception and complaint rates. However, wind-induced building motion can cause sopite syndrome or early onset motion sickness which adversely affects occupant wellbeing and work performance. This research aims to advance the understanding of the physiology of sopite syndrome, quantify the motion dosage that causes sopite syndrome and determine its adverse effects on building occupants in real-world motion environments. This knowledge is expected to guide the formulation of building motion acceptability criteria based on safe motion exposure duration to facilitate the design of tall building that promotes population health and wellbeing and lifts work performance and productivity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100181
Funder
Australian Research Council
Funding Amount
$183,413.00
Summary
Fieldwork or remote sensing? The blurred line of unmanned airborne systems. Fieldwork or remote sensing? The blurred line of unmanned airborne systems: The aim of the project is to develop a state-of-the-art Unmanned Airborne System (UAS) capability in support of field data acquisition. The system will provide highly detailed calibrated imagery of difficult or inaccessible survey sites and bridge the scale gap between in situ observations and imagery acquired by higher altitude airborne or satel ....Fieldwork or remote sensing? The blurred line of unmanned airborne systems. Fieldwork or remote sensing? The blurred line of unmanned airborne systems: The aim of the project is to develop a state-of-the-art Unmanned Airborne System (UAS) capability in support of field data acquisition. The system will provide highly detailed calibrated imagery of difficult or inaccessible survey sites and bridge the scale gap between in situ observations and imagery acquired by higher altitude airborne or satellite sensors. The UAS will have a diverse range of applications, including environmental monitoring, disaster management and recording sites of indigenous cultural significance. In addition, the system will be more flexible and cost effective than any other field or remote sensing tool.Read moreRead less