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Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Meshless, numerical modelling for polymer processing. The new modelling technology will significantly improve Australian polymer producers' competitiveness and their ability to respond to international market forces. The technology will lead to new opportunities for Australian companies that develop simulation software. Our consumers will benefit from improvements in the design of polymer products. Our researchers in rheology and computational mechanics will gain further opportunities to extend ....Meshless, numerical modelling for polymer processing. The new modelling technology will significantly improve Australian polymer producers' competitiveness and their ability to respond to international market forces. The technology will lead to new opportunities for Australian companies that develop simulation software. Our consumers will benefit from improvements in the design of polymer products. Our researchers in rheology and computational mechanics will gain further opportunities to extend the advances this project will make.Read moreRead less
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less
eSorghum as a bio-fuel feedstock for arid environments. Increasing fuel costs, finite resources and the need to develop more carbon neutral and cleaner fuels have created a need for renewable sources. Ethanol and future generation biofuels (butanol and more energy-rich alcohols) can be extracted from biomass sources. Sorghum is an ideal bioenergy feedstock in the hotter, drier areas of Northern Australia, where starch (grain), sugar and lignocellulose (stover) can be amassed in this water effi ....eSorghum as a bio-fuel feedstock for arid environments. Increasing fuel costs, finite resources and the need to develop more carbon neutral and cleaner fuels have created a need for renewable sources. Ethanol and future generation biofuels (butanol and more energy-rich alcohols) can be extracted from biomass sources. Sorghum is an ideal bioenergy feedstock in the hotter, drier areas of Northern Australia, where starch (grain), sugar and lignocellulose (stover) can be amassed in this water efficient plant. Identifying and manipulating the genes to enable the improvement of sorghum as a dedicated bioenergy crop, will enable the increased efficiency of the Australian biofuels industry and create sustainable rural industries.Read moreRead less
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a natio ....Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a nationally significant construction material known as Autoclaved Aerated Concrete. The material technologies developed by this research will lead to more efficient material use, a more sustainable materials solution and the potential to export the technology worldwide.Read moreRead less
Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport ne ....Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport near the sediment-water interface by a single domain approach, and link wave-dirven advective flow and contaminant in marine sediments. The research outcomes will provide a better prediction of the transformation behaviour of pollutants in contaminated sediments.Read moreRead less
Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian ....Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian history. The primary aim of this research project is to apply recently developed computational tools to better understand 3D slope behaviour and to develop rigorous stability solutions that can be used by design engineers. A better understanding of 3D slope failure will lead to more economic and safer slope designs.Read moreRead less