Towards A Diagnostic Test For Juvenile Idiopathic Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$661,670.00
Summary
Childhood arthritis is an autoimmune disease that affects around 6000 Australian children. It can be difficult to diagnose, but quick diagnosis is important to prevent ongoing pain and limit long term damage to joints. We have been able to use genetic information to predict which people have autoimmune celiac disease. In this project, we will find out how well genetic information can predict which children have childhood arthritis, and whether genetics can be used as a diagnostic test.
A Novel Role For The IL-2 Pathway In Type-1-diabetes.
Funder
National Health and Medical Research Council
Funding Amount
$548,548.00
Summary
Genes encoding IL-2 and its receptor are strongly linked to susceptibility to multiple autoimmune diseases, including type-1-diabetes. Despite the importance of this pathway in the immune system, it is not yet understood how the associated genes affect disease. In this study, a novel function for IL-2 expression by dendritic cells in normal self-tolerance is investigated. The impacts of dendritic cell produced IL-2 expression and linkage to autoimmunity will be elucidated in both mouse and man.
Dendritic Cells And CCAAT/enhancer Binding Protein-delta (CEBP?) In Neuroinflammation And Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$576,538.00
Summary
This projects aims to develop new treatments by finding the cells and chemicals that naturally stop inflammation in the central nervous system in diseases like MS. It also aims to test new treatments by delivering them to where this inflammation takes place. This targeted delivery should mean fewer side effects because the rest of the body is not exposed to the treatment. Hopefully this will reduce the impact of these diseases on the community, and reduce side effects for the patient.