CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule developmen ....CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule development. New knowledge of the plant growth processes through mechanistic analysis of organ induction provides the tools to optimise the legume's productivity, quality, and environment adaptation.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poison ....Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poisoning. However, OP degrading enzymes could be improved in many ways - we will evolve these enzymes to enhance their catalytic properties - to enable them to act more efficiently on an increased number of OPs. Read moreRead less
The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between ....The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.
Read moreRead less
Centre Of Research Excellence In Infectious Diseases Modelling To Inform Public Health Policy
Funder
National Health and Medical Research Council
Funding Amount
$2,600,064.00
Summary
Infectious diseases pose a global challenge, with substantial human and economic costs. Mathematical models provide valuable frameworks to assess likely benefits of interventions to control infection spread and burden. Leveraging existing NHMRC support, we will expand modeling capability to inform infectious disease control policy in Australia and our region. Focus areas include vaccine preventable disease, respiratory viruses and emerging pathogens, supported by innovative methods development.
More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and po ....More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and policies are being established. The researchers will work alongside housing providers and selected Indigenous communities in Western Australia and Northern Territory to develop procurement, construction and housing management practices that will meet the critical need for more affordable, appropriate and sustainable housing.Read moreRead less
Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP ....Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP residues. However, many pesticides are not removed rapidly and OP-degrading enzymes require modification(s) if they are to be useful environmental reagents - this can be achieved with directed evolution. Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
School principals’ diminishing wellbeing. School principals’ diminishing wellbeing. This project aims to investigate the effect of State Education Departments’ policy interventions designed to improve school principals’ flagging wellbeing. Increasing competition, accountability and public scrutiny make principals stressed; since their influence on students is second only to teachers’, this threatens Australia’s socioeconomic outcomes. The project will map policy interventions to changes in princ ....School principals’ diminishing wellbeing. School principals’ diminishing wellbeing. This project aims to investigate the effect of State Education Departments’ policy interventions designed to improve school principals’ flagging wellbeing. Increasing competition, accountability and public scrutiny make principals stressed; since their influence on students is second only to teachers’, this threatens Australia’s socioeconomic outcomes. The project will map policy interventions to changes in principals’ motivation and wellbeing, and share information about the most productive and cost effective interventions with key stakeholders across Australia. This research could reverse the declining wellbeing of Australia’s school leaders.Read moreRead less