Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
The invisible parents project - exploring the barriers to effective parental and community involvement in three Northern Territory Schools. Education outcomes in the Northern Territory, particularly for Indigenous students, lag far behind those of other Australians, to the point that the situation can be considered a national emergency. This research program will explore ways to improve parental involvement. This will inform the Smith Family's efforts to undertake early intervention for children ....The invisible parents project - exploring the barriers to effective parental and community involvement in three Northern Territory Schools. Education outcomes in the Northern Territory, particularly for Indigenous students, lag far behind those of other Australians, to the point that the situation can be considered a national emergency. This research program will explore ways to improve parental involvement. This will inform the Smith Family's efforts to undertake early intervention for children who are at risk of education failure. It will provide benefits to the rural and regional communities who feed schools in Darwin and Katherine and provide national benefits through making a significant contribution of anthropologically-informed knowledge on the determinants of successful school outcomes.Read moreRead less
Playing for Life: A Case Study in Childhood, Culture and Transition. This study will advance Australian research on identity formation in postcolonial societies; develop child-focused research in academic anthropology; align Australian Aboriginal Studies with recent international progress in the field of children's social imagination; innovate the analysis of transforming Indigenous worldviews; create a perspective for in-depth psychological research with Aboriginal Australians; build a rich res ....Playing for Life: A Case Study in Childhood, Culture and Transition. This study will advance Australian research on identity formation in postcolonial societies; develop child-focused research in academic anthropology; align Australian Aboriginal Studies with recent international progress in the field of children's social imagination; innovate the analysis of transforming Indigenous worldviews; create a perspective for in-depth psychological research with Aboriginal Australians; build a rich resource for comparative research and for teaching. It also offers distinct social benefits: fostering the understanding of Aboriginal children's social and mental needs in processes of cultural transformation; enhancing equality by identifying the positive potentials in children and Aboriginal society.
Read moreRead less
Determining implementation drivers in resilience education. Determining implementation drivers in resilience education. This project aims to develop implementation frameworks to help the education sector universally provide resilience education programmes. More young people have mental health problems. Although evidence-based resilience education reduces these problems, education sectors do not know how to address barriers to school provision. The solution is implementation research. This projec ....Determining implementation drivers in resilience education. Determining implementation drivers in resilience education. This project aims to develop implementation frameworks to help the education sector universally provide resilience education programmes. More young people have mental health problems. Although evidence-based resilience education reduces these problems, education sectors do not know how to address barriers to school provision. The solution is implementation research. This project will study system and school-level factors influencing primary and high school uptake of social and emotional learning curricula that enhance resilience; and implementation drivers at both system and school levels, and influences on uptake and student and staff resilience. The outcome is universal provision of resilience education programs that benefit young people.Read moreRead less
Incentivising On Country Aboriginal Employment: Anangu Futures. . This project aims to investigate the changing face of cultural tourism in central Australia and examine pathways towards sustainable aboriginal employment in and around Uluru-Kata Tjuta National Park. The project is significant because it brings together Aboriginal community members, industry and government stakeholders to identify micro-business opportunities, youth training initiatives, better relations across cultural divides, ....Incentivising On Country Aboriginal Employment: Anangu Futures. . This project aims to investigate the changing face of cultural tourism in central Australia and examine pathways towards sustainable aboriginal employment in and around Uluru-Kata Tjuta National Park. The project is significant because it brings together Aboriginal community members, industry and government stakeholders to identify micro-business opportunities, youth training initiatives, better relations across cultural divides, and the economic value of Aboriginal knowledge. Outcomes include a model for sustainable Aboriginal employment in remote and very remote contexts, and the development of culturally relevant and sustainable governing guidelines for regional investment. Benefits include more sustainable jobs for Aboriginal people.Read moreRead less
Securing the essential: assisting Indigenous communities and their service providers to sustainably manage water and energy supply. The provision of water and energy supplies to remote Aboriginal and Torres Strait Islander (ATSI) communities is a critical challenge for service providers. This project uses a novel unobtrusive smart metering system, aligned with culturally appropriate consultation with ATSI communities, to reveal patterns of household water and water related-energy consumption. Si ....Securing the essential: assisting Indigenous communities and their service providers to sustainably manage water and energy supply. The provision of water and energy supplies to remote Aboriginal and Torres Strait Islander (ATSI) communities is a critical challenge for service providers. This project uses a novel unobtrusive smart metering system, aligned with culturally appropriate consultation with ATSI communities, to reveal patterns of household water and water related-energy consumption. Significantly, the research aims to identify effective behavioural and technological water and energy efficiency strategies in three remote ATSI communities in Queensland, Northern Territory and Western Australia. A key outcome is to provide an adaptive evidence-based and community-driven handbook to facilitate the secure long-term supply and efficient use of energy and water resources in remote ATSI communities.Read moreRead less
School drug education for junior high school students in Victoria - Assessing the impact of a state-wide, evidence-based intervention
. Young people are faced with numerous and powerful influences to use both legal and illicit drugs, and drug education can play an important counterbalancing role in shaping a normative culture of safety, moderation and informed decision making in this group. The research will develop, implement and evaluate one all encompassing, evidence-based, drug education pr ....School drug education for junior high school students in Victoria - Assessing the impact of a state-wide, evidence-based intervention
. Young people are faced with numerous and powerful influences to use both legal and illicit drugs, and drug education can play an important counterbalancing role in shaping a normative culture of safety, moderation and informed decision making in this group. The research will develop, implement and evaluate one all encompassing, evidence-based, drug education program for junior high school students across Victoria. The study is unique in its size and scope and will be of national benefit because its findings will influence the nature of future drug education in all secondary schools in Australia.Read moreRead less
Strategies to reduce risk of heat induced illness during intermittent, high intensity activity in a tropical environment. Regular intermittent, high intensity physical activity (IHIA) affords protection against modern life-style diseases (type II diabetes, coronary heart disease and some cancers) but when conducted in the tropics, exposes persons to the risk of dehydration, heat cramps, hypotension, heat syncope, heat exhaustion and heat stroke. Australia has rapid population growth in the tropi ....Strategies to reduce risk of heat induced illness during intermittent, high intensity activity in a tropical environment. Regular intermittent, high intensity physical activity (IHIA) affords protection against modern life-style diseases (type II diabetes, coronary heart disease and some cancers) but when conducted in the tropics, exposes persons to the risk of dehydration, heat cramps, hypotension, heat syncope, heat exhaustion and heat stroke. Australia has rapid population growth in the tropics and key sporting fixtures have moved to the region. We have set up the research capability and must now move on a range of IHIA in sport, workplaces, armed and emergency services to provide strategies to reduce the risk of heat induced illness in a tropical environment.Read moreRead less