Harmonic analysis in rough contexts. Harmonic analysis is a set of mathematical techniques aimed at decomposing complex signals into simple pieces in a way that is reminiscent of the decomposition of sounds into harmonics. It is highly efficient in analysing signals in homogeneous media such as wave propagation through the air that underpins wireless communication technology. However, wave propagation through inhomogeneous media, such as the human body in medical imaging or the Earth in geophysi ....Harmonic analysis in rough contexts. Harmonic analysis is a set of mathematical techniques aimed at decomposing complex signals into simple pieces in a way that is reminiscent of the decomposition of sounds into harmonics. It is highly efficient in analysing signals in homogeneous media such as wave propagation through the air that underpins wireless communication technology. However, wave propagation through inhomogeneous media, such as the human body in medical imaging or the Earth in geophysical imaging, is much harder to model. Phenomena with random components, as considered in finance for instance, are also problematic. This project is an important part of an intense international research effort to develop harmonic analysis in such rough contexts.Read moreRead less
Virus and host genes and the outcome of infection. Viruses cause infection of all animals including people and the outcome of infection is highly variable. This project aims to use genetics to explain why some animals are more susceptible to particular virus infections and some strains of virus cause more severe diseases. The project will also explore whether all cells are similarly susceptible to killing by viruses.
The genetics of resistance to devil facial tumour disease. Tasmanian devils are on the brink of extinction due to a new contagious cancer: Devil Facial Tumour Disease (DFTD). The aim of this project is to determine the genetic nature of DFTD resistance in order to directly contribute to the conservation management of this iconic and ecologically important species. This research will generate fundamental information about genetic diversity in Tasmanian devils and establish the feasibility of bree ....The genetics of resistance to devil facial tumour disease. Tasmanian devils are on the brink of extinction due to a new contagious cancer: Devil Facial Tumour Disease (DFTD). The aim of this project is to determine the genetic nature of DFTD resistance in order to directly contribute to the conservation management of this iconic and ecologically important species. This research will generate fundamental information about genetic diversity in Tasmanian devils and establish the feasibility of breeding resistant animals for release into the wild. Read moreRead less
Socio-spatial implications of smart city development in India. The project aims to generate extensive new knowledge on the complex socio-spatial implications of smart city development; and the ways in which they have been further consolidated, expedited, and elevated in response to COVID, and to stimulate the pandemic-hit economies. It makes a significant contribution to smart urbanism discourse globally with a focus on equity and its special role at times of crisis. The outcomes include a Smart ....Socio-spatial implications of smart city development in India. The project aims to generate extensive new knowledge on the complex socio-spatial implications of smart city development; and the ways in which they have been further consolidated, expedited, and elevated in response to COVID, and to stimulate the pandemic-hit economies. It makes a significant contribution to smart urbanism discourse globally with a focus on equity and its special role at times of crisis. The outcomes include a Smart City Roadmap for advising diverse stakeholders on how to negotiate for and build inclusive smart cities - with significant benefits in strengthening existing, and building new connections between India and Australia in an area of bilateral national significance.Read moreRead less
Enhancing plant photosynthesis by engineering the carbon dioxide (CO2)-fixing enzyme Rubisco. Improving the ability of crops to use water, sunlight and fertiliser more efficiently would have economic benefits for Australia and ease the environmental impacts associated with agricultural practices. Photosynthesis research has confirmed that such improvements are theoretically possible by enhancing the efficiency of the protein, Rubisco, which initiates the conversion of carbon dioxide into carbon ....Enhancing plant photosynthesis by engineering the carbon dioxide (CO2)-fixing enzyme Rubisco. Improving the ability of crops to use water, sunlight and fertiliser more efficiently would have economic benefits for Australia and ease the environmental impacts associated with agricultural practices. Photosynthesis research has confirmed that such improvements are theoretically possible by enhancing the efficiency of the protein, Rubisco, which initiates the conversion of carbon dioxide into carbon compounds required for growth. The biotechnological research proposed here uses unique capabilities to improve our understanding of structural features in Rubisco that influence its assembly and functional efficiency in plants. This knowledge will pave the way for transplanting more efficient Rubisco into crops to improve their growth.Read moreRead less
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
The Spectral Theory and Harmonic Analysis of Geometric Differential Operators. The project will involve mathematical research of the highest international standard in two very active and far-reaching field of mathematics: quantum chaos, and harmonic analysis. Progress in these fields will have implications in areas such as communications technology (e.g. image compression), quantum theory, and mathematical analysis (e.g. partial differential equations).
Transforming tobacco policy to deliver societal benefits. This project aims to develop new regulatory options for tobacco to minimise the legal market while avoiding the adverse societal and economic impacts of transferring consumer demand to illegal tobacco products. It addresses a significant current concern about a growing illegal tobacco market and seeks to improve understanding of the impact of tobacco control policies on the illegal market, and the societal impacts. The project also seeks ....Transforming tobacco policy to deliver societal benefits. This project aims to develop new regulatory options for tobacco to minimise the legal market while avoiding the adverse societal and economic impacts of transferring consumer demand to illegal tobacco products. It addresses a significant current concern about a growing illegal tobacco market and seeks to improve understanding of the impact of tobacco control policies on the illegal market, and the societal impacts. The project also seeks to draw insights from illicit drug policy to understand potential consequences of greater restrictions on the legal tobacco market. The expected outcomes include an enhanced monitoring system for illicit tobacco and policy recommendations to achieve government goals of reducing smoking rates.Read moreRead less
Predictability in evolution: From behaviour to genome. This project aims to determine whether evolution is primarily unpredictable and stochastic, or predictable and constrained along certain pathways. By using a natural experiment that caused wood-feeding cockroaches to evolve into soil-burrowing cockroaches in response to climate change millions of years ago, this project will determine how the genomes of these organisms responded. This will show whether the same molecular changes are repeated ....Predictability in evolution: From behaviour to genome. This project aims to determine whether evolution is primarily unpredictable and stochastic, or predictable and constrained along certain pathways. By using a natural experiment that caused wood-feeding cockroaches to evolve into soil-burrowing cockroaches in response to climate change millions of years ago, this project will determine how the genomes of these organisms responded. This will show whether the same molecular changes are repeatedly used in the evolution of complex traits, including burrow construction. This will contribute to the understanding of how predictable evolution is at the molecular level, and provide insights into how genomes change in response to prolonged climate change.Read moreRead less
Operator algebras as models for dynamics and geometry. Operator algebra is the mathematical theory which describes quantum physics and predicts how quantum systems will behave. Through this project, the researcher's recent discoveries in operator algebra will give us new insight into the dynamics and geometry - that is, the behaviour and shape - of the quantum world.