Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and bi ....Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and biomedical research. The sensor network discipline also stand to benefit from the understanding of multi-object system and control framework. Read moreRead less
Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia. In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand th ....Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia. In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand the processes that control the generation of protective lymphocytes. It will deliver information that may enable a more targeted approach to vaccine-development and treatments of infections. As defective differentiation can also be a cause of leukemia it may also lead to targets of cancer treatment.Read moreRead less
What counts is what is counted: performance measurement and its consequences. Measuring public sector performance is important as it potentially improves services and saves money, but it has become increasingly time and resource consuming. This project will analyse performance measurement and its consequences, and generate information on how governments can contain its growth and reduce its undesirable consequences.
Increasing internet energy and cost efficiency by improving higher-layer protocols. Australians rely heavily on our telecommunications infrastructure due to our geographic dispersion. We are also very susceptible to climate change, given our reliance on agriculture. Information technology is consuming a rapidly increasing fraction of our power and our budget. This research will help to reverse both those trends, by finding novel and practical ways to use our infrastructure more efficiently, and ....Increasing internet energy and cost efficiency by improving higher-layer protocols. Australians rely heavily on our telecommunications infrastructure due to our geographic dispersion. We are also very susceptible to climate change, given our reliance on agriculture. Information technology is consuming a rapidly increasing fraction of our power and our budget. This research will help to reverse both those trends, by finding novel and practical ways to use our infrastructure more efficiently, and to minimise its energy use. This will enable the Australian telecommunications industry to provide better service (including to Australian industries and rural communities) at lower economic and environmental cost. This project will put Australia on the international stage as a leading contributor to energy-efficient internet technology.Read moreRead less
Curvature flows and spectral estimates. Curvature flows are a class of geometrically motivated equations, modelled on the heat equation. Recently, researchers have developed new methods for studying the regularity of solutions to these equations, and applied them to a different problem, that of estimating quantities depending on the smaller eigenvalues of a Schroedinger operator. This project builds on the early success of this research and will produce a new understanding of the behaviour of ei ....Curvature flows and spectral estimates. Curvature flows are a class of geometrically motivated equations, modelled on the heat equation. Recently, researchers have developed new methods for studying the regularity of solutions to these equations, and applied them to a different problem, that of estimating quantities depending on the smaller eigenvalues of a Schroedinger operator. This project builds on the early success of this research and will produce a new understanding of the behaviour of eigenvalues, establish sharp estimates for spectral quantities, particularly on manifolds with curvature bounds, and find optimal conditions under which non-compact solutions to curvature flows are stable.Read moreRead less
Easing urban congestion through intelligent use of distributed information. Vehicle-to-vehicle wireless communication can be a solution to road traffic congestion and control without enormous additional infrastructure costs. This project will investigate the fundamental properties of such solution and to devise the practical policies and protocols resulting in interacting game-like behaviours.
Next-generation techniques for analysing massive data sets. To process enormous amounts of data, leading computing companies are turning to modern computing frameworks, for which little theory of efficient computational techniques has been developed. This project will resolve key theoretical questions and provide fast techniques for poorly understood pattern recognition and bioinformatics problems.
New strategies for highly sensitive chemical detection based on luminescent ruthenium and iridium complexes. Chemical reactions that emit tiny quantities of light, not even visible to the naked eye, can be used to detect the biomarkers of disease or traces of chemical or biological weapons in a terrorist attack. This project creates a new generation of reagents for this remarkably sensitive mode of detection for these and other important applications.
Work, income, spending, and wellbeing in Australia: A multi-level, longitudinal analysis of individuals and households. Social science research on the effects of income on wellbeing is substantial, however, this research has largely missed five crucial factors. These factors include: the work people do to generate income; how they use income; effects on physical and social wellbeing; effects at the household level; and causal effects at multiple levels. This project aims to address all of these ....Work, income, spending, and wellbeing in Australia: A multi-level, longitudinal analysis of individuals and households. Social science research on the effects of income on wellbeing is substantial, however, this research has largely missed five crucial factors. These factors include: the work people do to generate income; how they use income; effects on physical and social wellbeing; effects at the household level; and causal effects at multiple levels. This project aims to address all of these factors with a new model of wellbeing, the Work-Income-Spending-Effects (WISE) model, and utilises the Household, Income and Labour Dynamics in Australia database. This project also aims to demonstrate trade-offs among work, income, spending, and multiple types of wellbeing within a new paradigm for engaging the Australian public, organisations, and policy makers.Read moreRead less