One Australian dies of Motor Neuron Disease (MND) every day. MND is likely to be due to a genetic susceptibility to an environmental agent such as a toxin or a virus. Recent advances in gene therapy have emphasised the urgent need to find the gene abnormalities in MND. We propose to set up an Australia-wide DNA Bank for MND to allow researchers to look for genetic abnormalities and environmental influences in this disease.
It is now well established that there are genetic factors contributing to risk of depression but it is far from clear what these are and how they interact with environmental risk factors such as stressful life events (SLE) and poor social support (SS). A recent, highly cited paper has claimed that those carrying a particular genotype at the sertonin transporter gene are much more badly affected by stressful life events than other genotypes, and that this puts these people at much higher risk of ....It is now well established that there are genetic factors contributing to risk of depression but it is far from clear what these are and how they interact with environmental risk factors such as stressful life events (SLE) and poor social support (SS). A recent, highly cited paper has claimed that those carrying a particular genotype at the sertonin transporter gene are much more badly affected by stressful life events than other genotypes, and that this puts these people at much higher risk of depression. If true, this could have important practical implications for preventative mental health, in identifying those at greatest risk if depression and counselling them to avoid stressful situations. However, success in replicating this finding has been mixed, and this is possibly because another important risk factor, social support, has not been taken into account. We have DNA samples from over 5000 twins who have been assessed for depression and risk factors including SLE and SS. This will give us unprecedented power to estimate the importance of the genotype x environment interaction. We shall also type other genes that have been implicated in depression and check for interactions with life events and social support. Our results will inform preventative strategies in mental health practice.Read moreRead less
Environmental and genetic control over blackwood (Acacia melanoxylon) timber colour, density, and recovery. The project will investigate the roles of environment and genetics in the expression of wood characteristics in blackwood. It will determine the potential heritability of valuable blackwood wood traits and provide a sound understanding of the basis of colour expression. Heartwood characteristics, particularly colour, density, ring width and knottiness determine the commercial value of blac ....Environmental and genetic control over blackwood (Acacia melanoxylon) timber colour, density, and recovery. The project will investigate the roles of environment and genetics in the expression of wood characteristics in blackwood. It will determine the potential heritability of valuable blackwood wood traits and provide a sound understanding of the basis of colour expression. Heartwood characteristics, particularly colour, density, ring width and knottiness determine the commercial value of blackwood. The limited research on these characteristics, all undertaken outside Australia, points to combined genetic and environmental control. By understanding the relative importance that environmental conditions and genetic material have in producing desirable wood traits, growers will be better able to realise the full commercial value of blackwood.Read moreRead less
Determining The Causes Of Congenital Vertebral Defects
Funder
National Health and Medical Research Council
Funding Amount
$956,136.00
Summary
Many birth defects cause vertebral malformations along the spinal column. These originate as the fetus forms, and we have previously shown that some of these are caused by gene mutation and/or environmental factors during gestation. However, the origins of many such defects remain unexplained. We will examine the DNA of a large number of patients to find more genes causing such defects. We will also test if these new genes predispose a fetus to being more susceptible to environmental influences.
Applying Next Generation Sequencing To Family Studies
Funder
National Health and Medical Research Council
Funding Amount
$182,622.00
Summary
Recent advances in technology can determine the DNA composition of a person for much longer stretches of DNA, at a much cheaper cost. I use statistical analysis to identify regions of the human genome that harbour mutations that cause diseases such as epilepsy in families. These regions contain 5-15 million base pairs. We need to find the ONE base pair that causes disease. This application deals with the development of new tools to exploit new technology for the identification of mutations.
We recently established the Centre for Neurogenetics and Statistical Genomics, a research centre within the Queensland Brain Institute. It was established to bring together a team of researchers with expertise in neurogenetics, neuropsychiatric genetics, statistical genomics and computational biology. During my Fellowship I will conduct research at this Centre to elucidate the genetic basis of neurogenetic diseases and psychiatric disorders, using genomic tools and data analysis.
Defining The Molecular Effectors Of Gene/environment Interaction On Mouse Heart Development
Funder
National Health and Medical Research Council
Funding Amount
$749,271.00
Summary
One third of all birth defects involve the heart, and are the most common cause of infant death. Some defects are due to genetic factors, but others arise when the pregnant mother is exposed to environmental stress. We will examine how one stress (low oxygen levels) causes abnormal heart formation in the embryo, look at what causes this at a molecular level, and explore if such stress increases the risk of heart defects in families with a history of such abnormalities
Improved growth of Pinus radiata through better modelling and management of photosynthesis and respiration. This research will use recently developed technologies to deliver the first comprehensive analysis of the effects of thinning and fertilizer on distribution of photosynthetically active proteins and nitrogenous metabolites in P. radiata. We seek to develop mechanistic and empirical understandings of photosynthesis, respiration, water use and growth and thus better model and predict effec ....Improved growth of Pinus radiata through better modelling and management of photosynthesis and respiration. This research will use recently developed technologies to deliver the first comprehensive analysis of the effects of thinning and fertilizer on distribution of photosynthetically active proteins and nitrogenous metabolites in P. radiata. We seek to develop mechanistic and empirical understandings of photosynthesis, respiration, water use and growth and thus better model and predict effects of management actions on yield of commercial softwood plantations. We will also apply similarly new but complementary and compatible technologies to assess photosynthesis, water use and respiration characteristics of a range of P. radiata genotypes of known growth potential. Our aim here is to develop new tools to help selection of high-yielding genotypes. The data collected will again be used to inform our development of a new growth model where the 'driver' of growth is respiration and where hydraulic architecture and soil water balance limits photosynthesis and water use.
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