Investigating Tumour Initiation And Growth In A Panel Of Mice Defective In Epigenetic Reprogramming.
Funder
National Health and Medical Research Council
Funding Amount
$421,600.00
Summary
Until recently it was believed that cancer is always caused by mutations in genes. Now it has been proposed that chemical modifications to the DNA and the proteins that package the DNA may also initiate cancer. These "epigenetic" modifications control whether our genes are switched on or off. Epigenetic modifications are disrupted in cancer, but it is not known whether they can start tumour growth. I will study this using mouse models. This work may lead to preventative screening and new treatme ....Until recently it was believed that cancer is always caused by mutations in genes. Now it has been proposed that chemical modifications to the DNA and the proteins that package the DNA may also initiate cancer. These "epigenetic" modifications control whether our genes are switched on or off. Epigenetic modifications are disrupted in cancer, but it is not known whether they can start tumour growth. I will study this using mouse models. This work may lead to preventative screening and new treatments in humans.Read moreRead less
A Piggy-back Screen For Genes Involved In Cancer Epigenetics
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
Cancer can be caused not only by mutations in genes, but also by changes to our epigenome, which controls whether genes are on or off. There is much still to learn about the epigenome. We have developed a method to identify epigenome regulators. The epigenome is disrupted in cancer, but it is not know whether this starts tumour growth. I will use mutant mice to study this and analyse human cancers for mutations in epigenome regulators. This may lead to preventative screening and new treatments.