New Developments for Bayesian statistical models and computational methods. Bayesian methods of statistical analysis provide a flexible theory for addressing inference in the presence of uncertainty. Consequently Bayesian methods have enabled scientific discovery in areas characterised as complex systems where new developments in modelling and computational methods have been crucial. Significant barriers to further success involve challenges in formulating and validating models, dealing with l ....New Developments for Bayesian statistical models and computational methods. Bayesian methods of statistical analysis provide a flexible theory for addressing inference in the presence of uncertainty. Consequently Bayesian methods have enabled scientific discovery in areas characterised as complex systems where new developments in modelling and computational methods have been crucial. Significant barriers to further success involve challenges in formulating and validating models, dealing with large data sets, and developing efficient computational methods. The principal aim of this project is to develop new Bayesian modelling and computational methodology which address these challenges with broad application.Read moreRead less
A toolkit of statistical methodology for a state-of-the-art software and decision support system for forest assessment using new airborne data. The aim is to develop statistical methods for efficient collection and interpretation of airborne laser data and videography, used to describe characteristics of the forest such as tree species, stand history and vertical distribution of foliage, and hence biodiversity and biomass. This is significant for meeting Australia's international and national en ....A toolkit of statistical methodology for a state-of-the-art software and decision support system for forest assessment using new airborne data. The aim is to develop statistical methods for efficient collection and interpretation of airborne laser data and videography, used to describe characteristics of the forest such as tree species, stand history and vertical distribution of foliage, and hence biodiversity and biomass. This is significant for meeting Australia's international and national environmental obligations, providing quality information to farmers and industry, and hence developing potential jobs in regional areas. Outcomes include a toolkit of statistical methods applicable to spatial modelling and analysis of very large datasets, a statistically valid software product, marketable estimation methods in carbon accounting, technology transfer, training, publications.Read moreRead less
Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinic ....Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinical trials for possible effective treatments of neurological diseases such as motor neurone disease to be conducted with an objective measurement of disease progression. Read moreRead less
Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most ....Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most industries in Australia. More specifically, it is to be applied here to the diagnosis and prognosis of ovarian cancer. This cross-disciplinary project will strengthen Australian researchers' capacity and capability of participating in cutting-edge DNA microarray research.
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Elicitation and Integration of Expert Information for Natural Resource Management with a Focus on Water. Australia's natural resource management requires integrating information from many sources, including survey data and community and expert opinion. We aim to develop statistical methods to formally combine this information and apply them to better management of our crucial resource, water. The project contributes significantly to Australia's international obligations, and government agency an ....Elicitation and Integration of Expert Information for Natural Resource Management with a Focus on Water. Australia's natural resource management requires integrating information from many sources, including survey data and community and expert opinion. We aim to develop statistical methods to formally combine this information and apply them to better management of our crucial resource, water. The project contributes significantly to Australia's international obligations, and government agency and regional group science-based decision-making.
Outcomes include increased fundamental knowledge in statistics, technology transfer and improved decision-making capacity for natural resource management.
The project builds on strong existing collaborations between academic and industry partners and provides foundation for future funded projects.
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Measuring and presenting uncertainty in complex natural resource monitoring programs. This project addresses Australia's key research goal of An Environmentally Sustainable Australia, priority goals of Water, Soil and Climate, and the theme of Complex Systems.Through improved capability in making data-based decisions and true sharing of university and government agency expertise, the project will enhance Australia's ability to better manage its natural resources, meet national and international ....Measuring and presenting uncertainty in complex natural resource monitoring programs. This project addresses Australia's key research goal of An Environmentally Sustainable Australia, priority goals of Water, Soil and Climate, and the theme of Complex Systems.Through improved capability in making data-based decisions and true sharing of university and government agency expertise, the project will enhance Australia's ability to better manage its natural resources, meet national and international environmental commitments, and address national demands for quality science underpinning decisions about natural resource managementRead moreRead less
Cross-Entropy Methods in Complex Biological Systems. The Cross-Entropy method provides a powerful new way to find superior solutions to complicated optimisation problems in biology, ranging from better design and implementation of medical treatments to an increased understanding of complex ecosystems.
Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a com ....Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a competitive advantage for various sections of the Australian industry, including telecommunications, biotechnology and finance. The project will enable Australian researchers to continue to work at the forefront of this fast moving and exciting area of international research.Read moreRead less
Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
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