Detection And Management Of Depression In General Practice Patients With Chronic Manifestations Of Ischaemic Heart Disea
Funder
National Health and Medical Research Council
Funding Amount
$499,797.00
Summary
This research will investigate the impact of ischemic heart disease on the prevalence and severity of patients with depression. This will be done via a 12 month general practice based program of 1) systematic screening for depression 2) informing general practitioners of best-practice guidelines for management of depression in these patients, and 3) providing the treating general practitioner with patient-specific, psychiatric advice.
Ultra-sensitive third-generation gravitational wave detectors. Second-generation gravitational wave detectors that will directly detect gravitational waves for the first time are currently being assembled. Their sensitivity will be limited by intrinsic thermal motion of the atoms in the mirror coatings and the quantum nature of the laser beams in the detectors. This project aims to develop new designs with the aim of circumventing these limitations and developing the ultra-sensitive optical metr ....Ultra-sensitive third-generation gravitational wave detectors. Second-generation gravitational wave detectors that will directly detect gravitational waves for the first time are currently being assembled. Their sensitivity will be limited by intrinsic thermal motion of the atoms in the mirror coatings and the quantum nature of the laser beams in the detectors. This project aims to develop new designs with the aim of circumventing these limitations and developing the ultra-sensitive optical metrology required to realise those designs. It is expected that the increased sensitivity of these third-generation detectors will allow more detailed measurement of the gravitational wave signals and provide unprecedented understanding of some of the most violent events in the universe.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100129
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Equipment and instrumentation for breaking the quantum measurement barrier. This equipment will support Australia's partnership in the international effort to detect gravitational waves, which would allow the first direct observation of black holes and mark the beginning of exploration of the gravitational wave spectrum.
Three-Mode interactions and optical springs in high power optical cavities. Gravitational waves are tiny vibrations of space and time which carry vast energy. They will allow the first direct observation of black holes. To make frequent detections this project will harness the force of intense laser light, and use this force to improve the sensitivity of gravitational wave detectors.
How The Lateral Habenula Integrates Behavioral And Autonomic Functions: The VTA Dopamine Connection
Funder
National Health and Medical Research Council
Funding Amount
$819,904.00
Summary
When adverse events occur, the lateral habenula, an old brain nucleus, helps calculate the wisest corrective action by contributing to the “brake” that controls the brain’s dopamine reward system. Our research will show how the lateral habenula links corrective changes in behavior with coordinated changes in temperature. Understanding this link will greatly contribute to understanding the brain mechanisms that regulate our physiology during stressful situations and as part of mental illness.
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100032
Funder
Australian Research Council
Funding Amount
$990,000.00
Summary
Australian partnership in advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) - continuation. Advanced Laser Interferometer Gravitational-Wave Obervatory (LIGO) will be the first gravitational wave observatory capable of frequent observation of known sources of gravitational waves leading to the birth of gravitational wave astronomy. By playing a key role in this facility, Australia will reap the scientific rewards of being part of the most exciting frontier of physics in the 2 ....Australian partnership in advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) - continuation. Advanced Laser Interferometer Gravitational-Wave Obervatory (LIGO) will be the first gravitational wave observatory capable of frequent observation of known sources of gravitational waves leading to the birth of gravitational wave astronomy. By playing a key role in this facility, Australia will reap the scientific rewards of being part of the most exciting frontier of physics in the 21st century.Read moreRead less
Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100121
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
Equipment for International Collaboration in Gravitational Wave Detection. Equipment for international collaboration in gravitational wave detection: This project will allow the Australian Consortium for Gravitational Astronomy to install optical equipment at its dedicated research facility, and to install data analysis pipelines on new iVEC Pawsey Centre GPU-enabled supercomputers. The equipment is required for research aimed at stabilising instabilities in the new international gravitational w ....Equipment for International Collaboration in Gravitational Wave Detection. Equipment for international collaboration in gravitational wave detection: This project will allow the Australian Consortium for Gravitational Astronomy to install optical equipment at its dedicated research facility, and to install data analysis pipelines on new iVEC Pawsey Centre GPU-enabled supercomputers. The equipment is required for research aimed at stabilising instabilities in the new international gravitational wave detectors currently being commissioned in the USA and Europe. Real time data from the new detectors will be analysed using innovative new techniques. Scientists across Australia will be able to rapidly localise potential gravitational wave sources to direct robotic telescope observations. This could enable the first detection of gravitational waves.Read moreRead less
Instrumentation for the era of gravitational wave science. This project aims to study noise sources that limit the low-frequency performance of gravitational wave antenna: thermal noise, quantum radiation pressure noise and Newtonian noise. Gravitational wave detection is a new way in which to observe our universe. Although detectors such as advanced LIGO (Laser Interferometer Gravitational-Wave Observatory) should detect gravitational waves, further sensitivity improvement, particularly at low ....Instrumentation for the era of gravitational wave science. This project aims to study noise sources that limit the low-frequency performance of gravitational wave antenna: thermal noise, quantum radiation pressure noise and Newtonian noise. Gravitational wave detection is a new way in which to observe our universe. Although detectors such as advanced LIGO (Laser Interferometer Gravitational-Wave Observatory) should detect gravitational waves, further sensitivity improvement, particularly at low frequencies, will be needed to provide event rates necessary for astronomy. Expected project outcomes will support the development of the first free mass interferometer to operate at 120K using silicon optics, a vital facility for the world community. Pushing the boundaries of measurement may also drive innovation in optical sensing with potential applications in defence, security and exploration.Read moreRead less