Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Gravitational-wave astrophysics of binary black holes. Do black holes live alone, or form lasting gravitational partnerships? This question is of immense significance to astronomers. The emerging field of gravitational-wave astronomy is set to provide the answers. This project aims to develop innovative strategies to search for black hole pairs using leading technologies built with Australian expertise.
Testing pulsar emission models and general relativity at pico arcsecond resolution. A holographic technique has been pioneered that harnesses scattering in interstellar space to resolve the emission from pulsars at a resolution of 50 pico-arcseconds, six orders of magnitude finer than has been achieved by conventional radio astronomical interferometry. This project will directly measure the size of the emission regions in a set of pulsars, and hence resolve the 40-year old debate regarding the s ....Testing pulsar emission models and general relativity at pico arcsecond resolution. A holographic technique has been pioneered that harnesses scattering in interstellar space to resolve the emission from pulsars at a resolution of 50 pico-arcseconds, six orders of magnitude finer than has been achieved by conventional radio astronomical interferometry. This project will directly measure the size of the emission regions in a set of pulsars, and hence resolve the 40-year old debate regarding the site of their radio emission. The project will also apply the technique to binary pulsar systems to provide a new test of General Relativity.Read moreRead less
Controlling parametric instabilities in advanced GW detectors. This project aims to solve the problem of parametric instability in gravitational wave detectors to support an international large-scale physics experiment. The project is part of Australia’s participation in the new advanced LIGO (Laser Interferometer Gravitational-Wave Observatory) gravitational wave detectors that have been designed to achieve the first detection of gravitational waves. A 2005 prediction made by the project leader ....Controlling parametric instabilities in advanced GW detectors. This project aims to solve the problem of parametric instability in gravitational wave detectors to support an international large-scale physics experiment. The project is part of Australia’s participation in the new advanced LIGO (Laser Interferometer Gravitational-Wave Observatory) gravitational wave detectors that have been designed to achieve the first detection of gravitational waves. A 2005 prediction made by the project leaders that the detectors would experience acoustic instabilities was confirmed during detector commissioning in 2014. The project team plans to work closely with the detector designers and commissioners to solve this problem and allow the detectors to achieve their target sensitivity.Read moreRead less
Weighing the Universe using fast radio bursts. Fast radio bursts are a newly-discovered astronomical phenomenon whose millisecond-timescale emission occurs at cosmological distances, rendering them exceptional probes of the matter that lies in intergalactic space. This project aims to measure the positions and obtain the distances to these bursts to make a direct measurement of the density of ordinary matter in the Universe, at least 50 per cent of which is believed to remain undetected in inter ....Weighing the Universe using fast radio bursts. Fast radio bursts are a newly-discovered astronomical phenomenon whose millisecond-timescale emission occurs at cosmological distances, rendering them exceptional probes of the matter that lies in intergalactic space. This project aims to measure the positions and obtain the distances to these bursts to make a direct measurement of the density of ordinary matter in the Universe, at least 50 per cent of which is believed to remain undetected in intergalactic space. This project will measure the distribution of this missing matter, and find how it has evolved throughout the history of the Universe. This will provide significant benefits, such as addressing two fundamental questions about our Universe: how much matter does it contain, and has a large fraction of it hitherto evaded detection in intergalactic space?Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100891
Funder
Australian Research Council
Funding Amount
$338,324.00
Summary
Probing cosmic transients through gravitational wave observations. This project aims to use recently discovered gravitational waves to discover what drives cataclysmic astrophysical events, how often they occur and their history. The first detection of gravitational waves has changed astronomy. This project will apply analysis and data mining to gravitational wave and gamma-ray burst data. The results are expected to reveal the connection between gamma ray bursts, gravitational wave sources and ....Probing cosmic transients through gravitational wave observations. This project aims to use recently discovered gravitational waves to discover what drives cataclysmic astrophysical events, how often they occur and their history. The first detection of gravitational waves has changed astronomy. This project will apply analysis and data mining to gravitational wave and gamma-ray burst data. The results are expected to reveal the connection between gamma ray bursts, gravitational wave sources and fast radio bursts, substantially advancing understanding of the Universe.Read moreRead less
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.