Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Gravitational-wave astrophysics of binary black holes. Do black holes live alone, or form lasting gravitational partnerships? This question is of immense significance to astronomers. The emerging field of gravitational-wave astronomy is set to provide the answers. This project aims to develop innovative strategies to search for black hole pairs using leading technologies built with Australian expertise.
Testing pulsar emission models and general relativity at pico arcsecond resolution. A holographic technique has been pioneered that harnesses scattering in interstellar space to resolve the emission from pulsars at a resolution of 50 pico-arcseconds, six orders of magnitude finer than has been achieved by conventional radio astronomical interferometry. This project will directly measure the size of the emission regions in a set of pulsars, and hence resolve the 40-year old debate regarding the s ....Testing pulsar emission models and general relativity at pico arcsecond resolution. A holographic technique has been pioneered that harnesses scattering in interstellar space to resolve the emission from pulsars at a resolution of 50 pico-arcseconds, six orders of magnitude finer than has been achieved by conventional radio astronomical interferometry. This project will directly measure the size of the emission regions in a set of pulsars, and hence resolve the 40-year old debate regarding the site of their radio emission. The project will also apply the technique to binary pulsar systems to provide a new test of General Relativity.Read moreRead less
Controlling parametric instabilities in advanced GW detectors. This project aims to solve the problem of parametric instability in gravitational wave detectors to support an international large-scale physics experiment. The project is part of Australia’s participation in the new advanced LIGO (Laser Interferometer Gravitational-Wave Observatory) gravitational wave detectors that have been designed to achieve the first detection of gravitational waves. A 2005 prediction made by the project leader ....Controlling parametric instabilities in advanced GW detectors. This project aims to solve the problem of parametric instability in gravitational wave detectors to support an international large-scale physics experiment. The project is part of Australia’s participation in the new advanced LIGO (Laser Interferometer Gravitational-Wave Observatory) gravitational wave detectors that have been designed to achieve the first detection of gravitational waves. A 2005 prediction made by the project leaders that the detectors would experience acoustic instabilities was confirmed during detector commissioning in 2014. The project team plans to work closely with the detector designers and commissioners to solve this problem and allow the detectors to achieve their target sensitivity.Read moreRead less
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Characterization Of Novel Regulators Of Erythropoiesis
Funder
National Health and Medical Research Council
Funding Amount
$437,545.00
Summary
Mature red and white blood cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for epo to stimulate them to become mature fu ....Mature red and white blood cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for epo to stimulate them to become mature functional cells. We have identified six molecules which interact with Lyn in red blood cells. We have shown that amolecule called HS1 is important for epo function in individual red blood cells and now we plan to investigate its functions in whole animals, including mice that lack the HS1 gene. We have also shown that a molecule called Trip1 is important for red blood cell development. Interestingly, this molecule also interacts with the thyroid hormone receptor and can influence the effects of epo and thyroid hormone on red blood cell development. The interplay between these two hormones will be looked at in more detail both at the cell and whole animal levels in normal mice and those lacking the thyroid hormone receptor gene. The third Lyn binding molecule we isolated is a novel gene-we have named it ankyrin repeat protein in line with the molecules it is related to. This gene is expressed in red blood cells and we aim to investigate what role it plays in the development of these cells. The fourth gene is also novel and is closely related to another called AFAP-110, which can exert effects on the structure of a cell. Its role in red blood cell structure will also be investigated. Finally, the last two molecule we have identified are both novel and are unrelated to any other known proteins. As above, the effects of these two molecules on red blood cell development will be investigated.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100008
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Australian Seismic Imaging Array. The project aims to create a facility for developing techniques for imaging the deep earth and the surface motion in ambient seismic waves created by wind, waves and human activity. The techniques will enable sources of seismic vibrations to be identified and suppressed, and will allow mapping techniques to be developed for monitoring and discovery of resources such as ground water. Gravitational wave researchers will benefit from the ability to suppress seismic ....Australian Seismic Imaging Array. The project aims to create a facility for developing techniques for imaging the deep earth and the surface motion in ambient seismic waves created by wind, waves and human activity. The techniques will enable sources of seismic vibrations to be identified and suppressed, and will allow mapping techniques to be developed for monitoring and discovery of resources such as ground water. Gravitational wave researchers will benefit from the ability to suppress seismic vibrations, while geophysicists will benefit from new techniques and training. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100129
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Equipment and instrumentation for breaking the quantum measurement barrier. This equipment will support Australia's partnership in the international effort to detect gravitational waves, which would allow the first direct observation of black holes and mark the beginning of exploration of the gravitational wave spectrum.