Can we exploit mRNA modifications to control protein expression? Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate ....Can we exploit mRNA modifications to control protein expression? Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate how we can exploit RNA modifications to modulate protein expression in a tractable single-celled organism with a small genome, Plasmodium. This information is important because understanding gene regulation is fundamental to all life, and the role of RNA modifications is emerging as integral to biotechnology.Read moreRead less
Embedded emissions accounting: frameworks for trade in a net-zero world. This project aims to inform Government on potential accounting frameworks for greenhouse emissions embedded in tradable products. Public frameworks are urgently needed given the emergence internationally of trade-related climate policies such as carbon border adjustment mechanisms. The project expects to contribute to global knowledge on embedded emissions frameworks by combining economic, engineering, science and policy pe ....Embedded emissions accounting: frameworks for trade in a net-zero world. This project aims to inform Government on potential accounting frameworks for greenhouse emissions embedded in tradable products. Public frameworks are urgently needed given the emergence internationally of trade-related climate policies such as carbon border adjustment mechanisms. The project expects to contribute to global knowledge on embedded emissions frameworks by combining economic, engineering, science and policy perspectives. Expected outcomes include improved: capability within Government; understanding among Australian stakeholders; and integration with international approaches. Expected benefits include lower regulatory barriers to global emissions reductions, and fairer access to international markets for Australian producers. Read moreRead less
Chemo-sensation in Ascaris infection. This project aims to show the role of chemo-sensation as an equally important target for worm control, and explore pathways to prevent infection. Parasitic worms cost global food/textile industry more than $100 billion dollars per year, and cause disease in more than 1 billion people and domesticated animals world-wide. This project will use a combination of imaging, systems biology, chemical biology and microfluidic methods to provide significant benefits, ....Chemo-sensation in Ascaris infection. This project aims to show the role of chemo-sensation as an equally important target for worm control, and explore pathways to prevent infection. Parasitic worms cost global food/textile industry more than $100 billion dollars per year, and cause disease in more than 1 billion people and domesticated animals world-wide. This project will use a combination of imaging, systems biology, chemical biology and microfluidic methods to provide significant benefits, such as exploring Ascaris chemo-sensation during larval migration, identify the key host queues and parasite genes regulating this process, and probe helminth chemosensation as a novel target for anti-parasitic treatments.Read moreRead less
Sugar transporters in coral symbiosis and origin of parasitism. We aim to identify how symbiotic algae feed sugar to their coral hosts. Corals need this algal sugar to exist, but no one knows how it is transferred, so understanding this crucial mechanism is hugely significant. The first benefit of this research will be a fundamental understanding about how two organisms (algae and coral) cooperate to build habitats like the Great Barrier Reef. We also aim to explore whether coral/algal coopera ....Sugar transporters in coral symbiosis and origin of parasitism. We aim to identify how symbiotic algae feed sugar to their coral hosts. Corals need this algal sugar to exist, but no one knows how it is transferred, so understanding this crucial mechanism is hugely significant. The first benefit of this research will be a fundamental understanding about how two organisms (algae and coral) cooperate to build habitats like the Great Barrier Reef. We also aim to explore whether coral/algal cooperation paved the way for the origin of parasitism. The second key outcome will be to identify the precise molecular mechanism that allowed parasitism to arise. This will benefit us through understanding the origins of important diseases such as human malaria and related infections of livestock and wildlife.
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Discovery Early Career Researcher Award - Grant ID: DE190100730
Funder
Australian Research Council
Funding Amount
$414,216.00
Summary
Designing for early engagement and wellbeing in palliative care. This project aims to generate design guidelines to assist architects in creating better palliative care environments to mitigate the stress associated with end-of-life events for patients, their families and healthcare teams. Facing death, either one’s own or that of a family member, is one of life’s most difficult experiences. Targeted design interventions can encourage early engagement with palliative care, enhance communication ....Designing for early engagement and wellbeing in palliative care. This project aims to generate design guidelines to assist architects in creating better palliative care environments to mitigate the stress associated with end-of-life events for patients, their families and healthcare teams. Facing death, either one’s own or that of a family member, is one of life’s most difficult experiences. Targeted design interventions can encourage early engagement with palliative care, enhance communication and social support in palliative care environments and support staff to deliver optimal patient care. These factors have all been shown to contribute positively to wellbeing. This project will provide benefits for patients, their families and healthcare teams.Read moreRead less
Inclusive memories: tracing democratic practices in contemporary memorials. This project aims to investigate the significant role of recent public memorials in reflecting and shaping democratic identity, memory, values and engagement in Australia and internationally. The project expects to advance knowledge through an innovative international comparison of the evolving diversity of democratic themes, designs and procurement approaches used for public memorials and public spaces. Expected outcome ....Inclusive memories: tracing democratic practices in contemporary memorials. This project aims to investigate the significant role of recent public memorials in reflecting and shaping democratic identity, memory, values and engagement in Australia and internationally. The project expects to advance knowledge through an innovative international comparison of the evolving diversity of democratic themes, designs and procurement approaches used for public memorials and public spaces. Expected outcomes include practical and scholarly insights into how these processes can improve social engagement and inclusion. The project’s benefits include improving decision-making processes for public art, public space and heritage, and expanding scholarly and public awareness about Australian history, identity and democratic values. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100901
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Narrating the Roles of Animals in Cultural Burning. This research aims to produce knowledge of the ways in which humans and animals co-construct landscapes via the medium of cultural burning. It will be the first multispecies ethnography of people and animals on Native Title land engaged in landscape modification based on the use of cultural fire. Taking its lead from Indigenous partners this research will develop narratives of how humans, and animals co-construct landscapes via the medium of fi ....Narrating the Roles of Animals in Cultural Burning. This research aims to produce knowledge of the ways in which humans and animals co-construct landscapes via the medium of cultural burning. It will be the first multispecies ethnography of people and animals on Native Title land engaged in landscape modification based on the use of cultural fire. Taking its lead from Indigenous partners this research will develop narratives of how humans, and animals co-construct landscapes via the medium of fire within wider socio-ecological frameworks. These narratives will inform policy and practice with regard to forest management, protection of species, conservation management, bushfire mitigation, promotion of biodiversity, and Indigenous health.Read moreRead less
Locating Giurgola: From Philadelphia School to Global Practice. This project aims to conduct the first major systematic assessment of the architectural career of Romaldo Giurgola (1920-2016), the principal architect of Australian Parliament House. It will review all known archives relating to his life and works, including significant collections in North America and Australia, and it will survey the full range of his architectural projects. The project expects to result in a new and complete ass ....Locating Giurgola: From Philadelphia School to Global Practice. This project aims to conduct the first major systematic assessment of the architectural career of Romaldo Giurgola (1920-2016), the principal architect of Australian Parliament House. It will review all known archives relating to his life and works, including significant collections in North America and Australia, and it will survey the full range of his architectural projects. The project expects to result in a new and complete assessment of Giurgola's architecture, figuring important Australian buildings into an international landscape of professional practice. The primary outcome of this project will be a large critical catalogue, presenting the full extent of his career for the first time and locating APH in that career in new terms.Read moreRead less
Architectural Work Cultures: professional identity, education and wellbeing. This project aims to examine the work and study cultures of architecture in Australia, in relation to professional identity, and in terms of impact on wellbeing, with a whole-of-career scope spanning education to retirement. It will generate the first comprehensive account of work-related wellbeing problems for both architectural practitioners and students, via qualitative and quantitative methods and a vigorous engagem ....Architectural Work Cultures: professional identity, education and wellbeing. This project aims to examine the work and study cultures of architecture in Australia, in relation to professional identity, and in terms of impact on wellbeing, with a whole-of-career scope spanning education to retirement. It will generate the first comprehensive account of work-related wellbeing problems for both architectural practitioners and students, via qualitative and quantitative methods and a vigorous engagement with the profession. Expected outcomes include two toolkits to assist the profession to support cultural change across educational, workplace and institutional settings. This should provide significant benefits for the wellbeing of architects at all career stages, and also support the long-term viability of the sector.Read moreRead less
Food and beverage price promotions: An untapped policy target . We aim to generate evidence on the influence of price promotions on foods and beverages considered to be of concern for human and planetary health. We further aim to identify if, and how, policies can be designed to reduce these types of price promotions and understand the feasibility and acceptability of doing so, from a range of perspectives.The significance of this project is substantial - unhealthy diets are the leading cause of ....Food and beverage price promotions: An untapped policy target . We aim to generate evidence on the influence of price promotions on foods and beverages considered to be of concern for human and planetary health. We further aim to identify if, and how, policies can be designed to reduce these types of price promotions and understand the feasibility and acceptability of doing so, from a range of perspectives.The significance of this project is substantial - unhealthy diets are the leading cause of disease and death and unhealthy foods account for >30% of the food-related environmental footprint. By understanding if, and how, this novel policy target can be designed to improve population food choices, this project will ultimately deliver benefits for human and planetary through improved dietary choices.Read moreRead less