Does a novel class of small RNA molecules control self-incompatibility in solanaceous plants? Self-incompatibility is a simple and genetically defined cell recognition system that prevents inbreeding in many plant species. Flowers of self-incompatible plants can distinguish self pollen from foreign pollen, and allow only foreign pollen to fertilise their egg cells. This proposal will investigate the possibility that the part of the genetic self-incompatibility locus controlling recognition of ....Does a novel class of small RNA molecules control self-incompatibility in solanaceous plants? Self-incompatibility is a simple and genetically defined cell recognition system that prevents inbreeding in many plant species. Flowers of self-incompatible plants can distinguish self pollen from foreign pollen, and allow only foreign pollen to fertilise their egg cells. This proposal will investigate the possibility that the part of the genetic self-incompatibility locus controlling recognition of pollen is a novel type of gene that encodes a small RNA molecule but no protein. Knowledge gained by studying the self-incompatibility genes will help us to understand how plant cells recognise each other, and may allow us to manipulate seed (and hence crop) production.Read moreRead less
The Role of High-Frequency Antigenic Variation in The Pathogenesis of Mycoplasma infection. The main goal of the proposed project is to understand the molecular mechanisms of phase/antigenic variation and its effects on mycoplasma pathogenesis. In this context I will use the well-characterised Mycoplasma synoviae haemagglutinin, MSPA, to establish the role of its phase-variable expression in the type and extent of M. synoviae disease. Additionally, the relationship between MSPA phase variation a ....The Role of High-Frequency Antigenic Variation in The Pathogenesis of Mycoplasma infection. The main goal of the proposed project is to understand the molecular mechanisms of phase/antigenic variation and its effects on mycoplasma pathogenesis. In this context I will use the well-characterised Mycoplasma synoviae haemagglutinin, MSPA, to establish the role of its phase-variable expression in the type and extent of M. synoviae disease. Additionally, the relationship between MSPA phase variation and gene rearrangements in the MSPB-encoding gene will be elucidated. The results will contribute to our understanding of the pathogenesis of bacterial disease and of the evolution of pathogenic mechanisms in bacterial pathogens.Read moreRead less
New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. ....New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. However, the Australian gene pool has very limited genetic diversity in grain textures and thus possibly in pathogen resistance. The project will work out the science behind these two traits and identify lines with new variants of textures and pathogen resistances, thus greatly benefiting the national infrastructure and local primary industries.Read moreRead less
'Sea change' communities: inter-generational perception and sense of place. The aim of this research is to establish a more rigorous method of evaluating the impact of the sea change process on the built and natural environments of coastal settlements. It will assist those communities to implement effective, place-sensitive sustainable planning and associated development practices.
Can we exploit mRNA modifications to control protein expression? Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate ....Can we exploit mRNA modifications to control protein expression? Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate how we can exploit RNA modifications to modulate protein expression in a tractable single-celled organism with a small genome, Plasmodium. This information is important because understanding gene regulation is fundamental to all life, and the role of RNA modifications is emerging as integral to biotechnology.Read moreRead less
Complex and nonlinear pattern analysis in architectural space, form and program: developing computational tools to support social and cultural design. In a country that is experiencing increasing urban density there is an urgent need for the development of tools and models for the production of socially and culturally responsive environments. The Fellowship develops a new quantitative and qualitative understanding of the experiential and semiotic characteristics of buildings. The project, assis ....Complex and nonlinear pattern analysis in architectural space, form and program: developing computational tools to support social and cultural design. In a country that is experiencing increasing urban density there is an urgent need for the development of tools and models for the production of socially and culturally responsive environments. The Fellowship develops a new quantitative and qualitative understanding of the experiential and semiotic characteristics of buildings. The project, assisted by developments in robotics technology, produces a leading-edge computational model for analysing complex and non-linear patterns in architectural space, form and program from a social and cultural perspective. Such a model will assist design practitioners, scholars, town planners and policy writers to shape rich, responsive and inclusive architectural environments.Read moreRead less
Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions w ....Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions will be re-evaluated in the context of contemporary economic, social and environmental criteria to enable existing multi-criteria models to deliver more sustainable outcomes that are also feasible and in the national interest, and consequently minimise the industry's current exposure to future climate change.Read moreRead less
Strategic Assessment of Building Adaptive Reuse Opportunities. This research will review a large database of existing buildings, many of which have exceeded their useful life. An innovative model will be developed to enable Australia's building and property industries to identify the most viable opportunities for building adaptive reuse. The model will integrate financial, environmental and social sustainability, enabling community stakeholders to make informed decisions with widespread benefits ....Strategic Assessment of Building Adaptive Reuse Opportunities. This research will review a large database of existing buildings, many of which have exceeded their useful life. An innovative model will be developed to enable Australia's building and property industries to identify the most viable opportunities for building adaptive reuse. The model will integrate financial, environmental and social sustainability, enabling community stakeholders to make informed decisions with widespread benefits. The research is aligned with the national priority area: An Environmentally Sustainable Australia: Transforming Existing Industries. The expertise developed in this project will be regionally and internationally applicable, providing momentum for the growing adaptive design and conservation market.Read moreRead less
Modelling greenhouse gas emissions associated with commercial building construction. A reliable model of greenhouse gas emissions for commercial building construction is required. Construction product manufacturing emissions are well known, but those associated with the construction process (representing up to 25% of the energy embodied in construction products) have not been fully elucidated. Commercial building construction requires more energy per square metre than residential building constr ....Modelling greenhouse gas emissions associated with commercial building construction. A reliable model of greenhouse gas emissions for commercial building construction is required. Construction product manufacturing emissions are well known, but those associated with the construction process (representing up to 25% of the energy embodied in construction products) have not been fully elucidated. Commercial building construction requires more energy per square metre than residential building construction, due mainly to lifting of heavy items. The results will be used to develop cost effective strategies for optimising greenhouse gas emissions associated with the total emissions from commercial building construction and operation. This will improve the environmental performance of the Australian construction industry.Read moreRead less
Embodied energy modelling of individual commercial buildings. This research will develop a method for modelling the energy embodied in individual commercial building construction. Construction material manufacturing emissions are well known in most industries, but the total embodied energy of the construction supply chain is difficult to model for individual buildings. For efficient commercial buildings, the embodied energy can represent up to 40 years of operational energy. The results will be ....Embodied energy modelling of individual commercial buildings. This research will develop a method for modelling the energy embodied in individual commercial building construction. Construction material manufacturing emissions are well known in most industries, but the total embodied energy of the construction supply chain is difficult to model for individual buildings. For efficient commercial buildings, the embodied energy can represent up to 40 years of operational energy. The results will be used to develop cost effective strategies for optimising the total life cycle energy of individual commercial buildings. This will in part improve the environmental performance of the Australian construction industry.Read moreRead less