Environmental Influences On Allergic Airways Disease From Birth To 8yrs: Long-term Outcomes Of A Randomised Trial (CAPS)
Funder
National Health and Medical Research Council
Funding Amount
$530,000.00
Summary
The prevalence of asthma in Australia is among the highest in the world yet no trials of primary prevention have been conducted which address the most common known causative agent (housedust mite allergens) and the most common known protective factor (dietary omega-3 fatty acids). Until the effectiveness of interventions which address these factors is certain, it will not be possible to give confident advice about how to prevent asthma. We are applying to continue follow up of the cohort of the ....The prevalence of asthma in Australia is among the highest in the world yet no trials of primary prevention have been conducted which address the most common known causative agent (housedust mite allergens) and the most common known protective factor (dietary omega-3 fatty acids). Until the effectiveness of interventions which address these factors is certain, it will not be possible to give confident advice about how to prevent asthma. We are applying to continue follow up of the cohort of the Childhood Asthma Prevention Study (CAPS) which has been underway since mid-1997. CAPS is a randomised controlled trial in which 616 infants at high risk of developing asthma because of a family history have been enrolled. The interventions include allergen reduction and dietary supplementation with omega-3 fatty acids. The interventions are designed to have maximum effect but be simple to implement by parents. Objective and subjective measurements of exposures, atopy, diet and asthmatic symptoms are being collected at 3 month intervals and at medical assessments when the children are 18 months, 3 and 5 years old. The interventions are stopped at age 5 years. The continued follow up of the cohort to age 8 will enable us to test conclusively if the interventions have had a positive effect. If so, CAPS will form the basis for a nationwide public health campaign which will have the potential to reduce the incidence of childhood asthma in Australia.Read moreRead less
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Transport And Egress Of Herpes Simplex Virus In Neurones
Funder
National Health and Medical Research Council
Funding Amount
$592,023.00
Summary
Herpes simplex virus (HSV) enters the human body via the skin before entering the termini of nerve cell processes. It is transported along these processes to the body of the nerve cell. HSV lies dormant within these nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported back down the nerve cell processes to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how HSV is transpor ....Herpes simplex virus (HSV) enters the human body via the skin before entering the termini of nerve cell processes. It is transported along these processes to the body of the nerve cell. HSV lies dormant within these nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported back down the nerve cell processes to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how HSV is transported within nerve cells at the molecular level. Recent discoveries have shown how virus transport in nerve cells is dependent on interactions between specific viral proteins and cellular motor proteins and how the virus escapes from nerves to infect skin and cause disease. Such information on viral transport will allow development of inhibitors of this process which may be candidates for use as antivirals for control of recurrent herpes simplex. In addition, this information will allow the virus to be exploited for use in gene therapy to introduce DNA into human nerve cells to correct genetic abnormalities. Finally this data will assist in understanding similar mechanisms for other viruses transported in nerve cells such as those causing shingles and rabies.Read moreRead less
Complex and nonlinear pattern analysis in architectural space, form and program: developing computational tools to support social and cultural design. In a country that is experiencing increasing urban density there is an urgent need for the development of tools and models for the production of socially and culturally responsive environments. The Fellowship develops a new quantitative and qualitative understanding of the experiential and semiotic characteristics of buildings. The project, assis ....Complex and nonlinear pattern analysis in architectural space, form and program: developing computational tools to support social and cultural design. In a country that is experiencing increasing urban density there is an urgent need for the development of tools and models for the production of socially and culturally responsive environments. The Fellowship develops a new quantitative and qualitative understanding of the experiential and semiotic characteristics of buildings. The project, assisted by developments in robotics technology, produces a leading-edge computational model for analysing complex and non-linear patterns in architectural space, form and program from a social and cultural perspective. Such a model will assist design practitioners, scholars, town planners and policy writers to shape rich, responsive and inclusive architectural environments.Read moreRead less
Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions w ....Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions will be re-evaluated in the context of contemporary economic, social and environmental criteria to enable existing multi-criteria models to deliver more sustainable outcomes that are also feasible and in the national interest, and consequently minimise the industry's current exposure to future climate change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454052
Funder
Australian Research Council
Funding Amount
$733,595.00
Summary
Tandem Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometer and Robots for High Throughput Proteomics Analysis. This proposal seeks to establish the capacity to perform high-energy tandem mass spectrometry on a high throughput basis, through purchase and coordinated operation of a Matrix-Assisted Laser Desorption/Ionisation - Time of Flight / Time of Flight - Mass Spectrometer and ancillary equipment, to enhance the proteomics expertise, infrastructure and research plans ....Tandem Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometer and Robots for High Throughput Proteomics Analysis. This proposal seeks to establish the capacity to perform high-energy tandem mass spectrometry on a high throughput basis, through purchase and coordinated operation of a Matrix-Assisted Laser Desorption/Ionisation - Time of Flight / Time of Flight - Mass Spectrometer and ancillary equipment, to enhance the proteomics expertise, infrastructure and research plans of a network of institutions from Queensland and New South Wales and their collaborators. Access to such instrumentation is critical to high level achievement in proteomics, a key platform technology for National Research Priorities relating to Frontier Technologies. No comparable instrument currently exists in Australia.Read moreRead less
Defining The Molecular Effectors Of Gene/environment Interaction On Mouse Heart Development
Funder
National Health and Medical Research Council
Funding Amount
$749,271.00
Summary
One third of all birth defects involve the heart, and are the most common cause of infant death. Some defects are due to genetic factors, but others arise when the pregnant mother is exposed to environmental stress. We will examine how one stress (low oxygen levels) causes abnormal heart formation in the embryo, look at what causes this at a molecular level, and explore if such stress increases the risk of heart defects in families with a history of such abnormalities
Attitudes and Behaviours in Consumer Spaces: Quantifying the Benefits of a Sustainable Retail Environment. The project provides a new level of understanding of the impact of retail environments that are ecologically responsible. Almost one quarter of the ecological footprint of the built environment in Australia is associated with some form of consumer space. While there are more than 8,000,000m2 of lettable retail environments in major centres alone in Australia, the ecological footprint of thi ....Attitudes and Behaviours in Consumer Spaces: Quantifying the Benefits of a Sustainable Retail Environment. The project provides a new level of understanding of the impact of retail environments that are ecologically responsible. Almost one quarter of the ecological footprint of the built environment in Australia is associated with some form of consumer space. While there are more than 8,000,000m2 of lettable retail environments in major centres alone in Australia, the ecological footprint of this space is far higher. This footprint may be minimised if the right combination of design and behavioural solutions can be enabled. But before this can occur, a detailed understanding of these complex attitudinal and behavioural issues must be developed. Read moreRead less
An Analysis of the Cultural, Social and Symbolic Performance of Computer-Generated, Post-Euclidean, Architecture in Australia. Computer Aided Design software has recently provided architects with the ability to use post-Euclidean geometry for the creation of buildings. As the first of these buildings are only now being completed the social, cultural and symbolic performance of this new approach to design remains unknown.
The present research seeks to redress this situation by analysing computer ....An Analysis of the Cultural, Social and Symbolic Performance of Computer-Generated, Post-Euclidean, Architecture in Australia. Computer Aided Design software has recently provided architects with the ability to use post-Euclidean geometry for the creation of buildings. As the first of these buildings are only now being completed the social, cultural and symbolic performance of this new approach to design remains unknown.
The present research seeks to redress this situation by analysing computer-generated public buildings, completed in Australia after 1998. These buildings represent a substantial outlay of public funding and a significant social investment in Australian cities.
This research will result in a critical evaluation strategy for public and institutional bodies interested in procuring such buildings.Read moreRead less
Embodied energy modelling of individual commercial buildings. This research will develop a method for modelling the energy embodied in individual commercial building construction. Construction material manufacturing emissions are well known in most industries, but the total embodied energy of the construction supply chain is difficult to model for individual buildings. For efficient commercial buildings, the embodied energy can represent up to 40 years of operational energy. The results will be ....Embodied energy modelling of individual commercial buildings. This research will develop a method for modelling the energy embodied in individual commercial building construction. Construction material manufacturing emissions are well known in most industries, but the total embodied energy of the construction supply chain is difficult to model for individual buildings. For efficient commercial buildings, the embodied energy can represent up to 40 years of operational energy. The results will be used to develop cost effective strategies for optimising the total life cycle energy of individual commercial buildings. This will in part improve the environmental performance of the Australian construction industry.Read moreRead less