An Analysis of the Cultural, Social and Symbolic Performance of Computer-Generated, Post-Euclidean, Architecture in Australia. Computer Aided Design software has recently provided architects with the ability to use post-Euclidean geometry for the creation of buildings. As the first of these buildings are only now being completed the social, cultural and symbolic performance of this new approach to design remains unknown.
The present research seeks to redress this situation by analysing computer ....An Analysis of the Cultural, Social and Symbolic Performance of Computer-Generated, Post-Euclidean, Architecture in Australia. Computer Aided Design software has recently provided architects with the ability to use post-Euclidean geometry for the creation of buildings. As the first of these buildings are only now being completed the social, cultural and symbolic performance of this new approach to design remains unknown.
The present research seeks to redress this situation by analysing computer-generated public buildings, completed in Australia after 1998. These buildings represent a substantial outlay of public funding and a significant social investment in Australian cities.
This research will result in a critical evaluation strategy for public and institutional bodies interested in procuring such buildings.Read moreRead less
Designer DNA-binding factors. This project aims to use a natural transcription factor family to enhance the efficiency and functionality of designer DNA-binding factors. Research into the structure and function of zinc finger transcription factors, TAL effectors and CRISPR created designer DNA-binding factors. However, though research has improved the specificity of these factors’ genome-wide binding, their efficacy in regulating the expression of genes requires improvement. Using sequencing, th ....Designer DNA-binding factors. This project aims to use a natural transcription factor family to enhance the efficiency and functionality of designer DNA-binding factors. Research into the structure and function of zinc finger transcription factors, TAL effectors and CRISPR created designer DNA-binding factors. However, though research has improved the specificity of these factors’ genome-wide binding, their efficacy in regulating the expression of genes requires improvement. Using sequencing, the project intends to enhance the efficiency and function of these factors by designing modules to improve the stability of DNA binding and effectiveness in functionally regulating gene expression. The project outcomes could include knowledge enabling the use of genetically engineered DNA-binding proteins to artificially control gene expression, with significant scientific and economic implications.Read moreRead less
Decorum as an Idea in Architecture, from the Renaissance to the Present. Examines the theory and practice of decorum in architecture from the Renaissance to the present day. The principal aims are to set decorum within the history of ideas and to establish the relevance of the concept to modernism and contemporary debates on the nature of architecture. The project will be empirically innovative and significant to both historians and theorists. The expected outcome is a book-length study.
Campus: Building Modern Australian Universities. This project plans to examine the post-World War Two evolution of the Australian university campus. Modern campuses created opportunities for the realisation of innovative solutions in urban planning, architecture and landscape. The project plans to reveal the physical impacts of political, institutional, social and cultural demands through comparative thematic investigation, digital visualisation and detailed case studies. Foregrounding landscape ....Campus: Building Modern Australian Universities. This project plans to examine the post-World War Two evolution of the Australian university campus. Modern campuses created opportunities for the realisation of innovative solutions in urban planning, architecture and landscape. The project plans to reveal the physical impacts of political, institutional, social and cultural demands through comparative thematic investigation, digital visualisation and detailed case studies. Foregrounding landscape and site, the project aims to establish new historical knowledge, identify campuses as catalysts for urban thinking, and demonstrate strategies for their conservation and adaptation to meet future needs in the tertiary sector.Read moreRead less
Sugar transporters in coral symbiosis and origin of parasitism. We aim to identify how symbiotic algae feed sugar to their coral hosts. Corals need this algal sugar to exist, but no one knows how it is transferred, so understanding this crucial mechanism is hugely significant. The first benefit of this research will be a fundamental understanding about how two organisms (algae and coral) cooperate to build habitats like the Great Barrier Reef. We also aim to explore whether coral/algal coopera ....Sugar transporters in coral symbiosis and origin of parasitism. We aim to identify how symbiotic algae feed sugar to their coral hosts. Corals need this algal sugar to exist, but no one knows how it is transferred, so understanding this crucial mechanism is hugely significant. The first benefit of this research will be a fundamental understanding about how two organisms (algae and coral) cooperate to build habitats like the Great Barrier Reef. We also aim to explore whether coral/algal cooperation paved the way for the origin of parasitism. The second key outcome will be to identify the precise molecular mechanism that allowed parasitism to arise. This will benefit us through understanding the origins of important diseases such as human malaria and related infections of livestock and wildlife.
Read moreRead less
Engineering a chromatin looping factor for artificial gene regulation. This project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synth ....Engineering a chromatin looping factor for artificial gene regulation. This project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synthetic looping factors that can switch on a wide array of target genes. The project aims to answer fundamental questions about how proteins can establish and maintain physical loops in DNA to modulate gene expression. The project will also develop research tools that might ultimately correct diseases caused by the faulty expression of genes.Read moreRead less
International Trade, Climate Change and Economic Policy. The research project addresses the role of, and interactions between, environmental and international trade policies within the context of a global economy with increasingly open economies whose production and consumption activities generate emissions of greenhouse gases that accumulate in the atmosphere and have potentially adverse effects on the world’s climate, which then impacts the environment, production and households. The objective ....International Trade, Climate Change and Economic Policy. The research project addresses the role of, and interactions between, environmental and international trade policies within the context of a global economy with increasingly open economies whose production and consumption activities generate emissions of greenhouse gases that accumulate in the atmosphere and have potentially adverse effects on the world’s climate, which then impacts the environment, production and households. The objective is to develop better understanding of the nexus between the international economy, climate change through the environment, and international trade and environmental policies. It will achieve this objective by analyses of multi-country models of international trade, climate change and policy design.Read moreRead less
Recomputing the canon: using computational methods to develop an alternative understanding of the history of 20th century architecture. Because buildings are designed to last for many generations, and they represent a substantial economic investment, architecture remains one of the most tangible and persistent reflections of a culture's spiritual, social and political values. This is why it is said, to understand architecture is to understand society and its principles. This research develops an ....Recomputing the canon: using computational methods to develop an alternative understanding of the history of 20th century architecture. Because buildings are designed to last for many generations, and they represent a substantial economic investment, architecture remains one of the most tangible and persistent reflections of a culture's spiritual, social and political values. This is why it is said, to understand architecture is to understand society and its principles. This research develops an alternative history of 20th century architecture that will not only allow for a deeper understanding of, and appreciation for, our own constructed heritage, but will also inform the design and production of future buildings which are both socially and culturally responsive.Read moreRead less
Sugars in the real world: are cultured cancer cells a good model system for studying protein glycosylation? It is challenging to study errors in metabolism in human beings, so researchers use cells grown in the laboratory to understand disease processes. This project will determine if cultured cells accurately reflect the real changes to cell surface sugars that occur in all cancers, and the effect of these changes on the invasive properties of colon cancer cells.
Occupant comfort, cognitive performance and task performance in wind-excited tall buildings. Strong winds are sensitive to climate change and highly unpredictable, critically affecting the design of tall buildings and our built environment. The outcomes of this research will revolutionalise current design approach for occupant comfort in wind-excited tall buildings and deliver a new generation of tall buildings that provides a comfortable living and working environment without a degradation of w ....Occupant comfort, cognitive performance and task performance in wind-excited tall buildings. Strong winds are sensitive to climate change and highly unpredictable, critically affecting the design of tall buildings and our built environment. The outcomes of this research will revolutionalise current design approach for occupant comfort in wind-excited tall buildings and deliver a new generation of tall buildings that provides a comfortable living and working environment without a degradation of work performance due to wind-induced vibration. The transfer of this knowledge from research to practice will enhance the international competitiveness of our architecture, engineering and construction professionals, boosting our involvement in major tall building projects worldwide and bringing long-term economical benefits to Australia.Read moreRead less