A Structural And Functional Basis For The Regulation Of Gene Expression By Nuclear Retention Of RNA
Funder
National Health and Medical Research Council
Funding Amount
$504,097.00
Summary
The nuclear retention mechanism is a novel way used by cells to control which genes are made into proteins - a fundamental process for all diseases, particularly cancers. This project will employ cutting edge structural and proteomic techniques to determine the molecular details underpinning nuclear retention. These insights will be important for the development of new tissue-restricted gene therapy applications and drugs targeting the cancers that rely on this mechanism.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$555,892.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Regulation Of Expression Of MicroRNAs Involved In EMT
Funder
National Health and Medical Research Council
Funding Amount
$559,354.00
Summary
The majority of deaths from cancer are due to metastasis, which involves cancer cells becoming invasive and migratory. We aim to understand the molecular mechanisms that control this process, which may lead to identification of molecules that are potentially useful for diagnosing and treating cancer metastasis. We will investigate how TGF� regulates the expression of ZEB proteins, how the ZEB proteins function to repress key microRNAs, and what other genes are targeted by the ZEBs.