Symmetries in CR-geometry. This project aims at investigating symmetries of geometric objects called CR-manifolds. It is expected to open new avenues for understanding such symmetries at the infinitesimal level and lead to ground-breaking results in CR-geometry. Expected outcomes include new methodology, solving long-standing problems, and establishing international research collaborations. The benefits are in enhancing the strength of the research in analysis and geometry performed in Australia ....Symmetries in CR-geometry. This project aims at investigating symmetries of geometric objects called CR-manifolds. It is expected to open new avenues for understanding such symmetries at the infinitesimal level and lead to ground-breaking results in CR-geometry. Expected outcomes include new methodology, solving long-standing problems, and establishing international research collaborations. The benefits are in enhancing the strength of the research in analysis and geometry performed in Australia, in fostering the international competitiveness of Australian research and in high-quality research training.Read moreRead less
Nilpotent associative algebras and spherical hypersurfaces. This project concerns pure basic research in mathematics and is based on an important recently discovered relationship between certain geometric and algebraic objects. In the project, this relationship will be applied in a novel way to solve several significant long-standing problems in the research area of complex geometry.
The Reconstruction and Recognition Problems for Hypersurface Singularities. This project concerns pure basic research in mathematics. It is centred around a surprising relationship between geometric objects called quasi-homogeneous isolated hypersurface singularities, and algebraic structures described as Artinian Gorenstein algebras. This relationship has not been fully understood despite numerous attempts by internationally based experts to shed light on it. Armed with a novel approach to Arti ....The Reconstruction and Recognition Problems for Hypersurface Singularities. This project concerns pure basic research in mathematics. It is centred around a surprising relationship between geometric objects called quasi-homogeneous isolated hypersurface singularities, and algebraic structures described as Artinian Gorenstein algebras. This relationship has not been fully understood despite numerous attempts by internationally based experts to shed light on it. Armed with a novel approach to Artinian Gorenstein algebras, this project proposes to clarify the nature of this relationship and utilise it for solving related geometric and algebraic problems. In particular, it aims at obtaining a groundbreaking result in the area of classical invariant theory.Read moreRead less
Proper Group Actions in Complex Geometry. The results of the project will enhance Australia's performance in several key mathematical areas as well as mathematical applications to physics critical for expanding Australia's knowledge base and research capability. The project has strong international aspects, it will foster the international competitiveness of Australian research and establish long-term collaborations between Australian researchers and high profile world experts in the area of the ....Proper Group Actions in Complex Geometry. The results of the project will enhance Australia's performance in several key mathematical areas as well as mathematical applications to physics critical for expanding Australia's knowledge base and research capability. The project has strong international aspects, it will foster the international competitiveness of Australian research and establish long-term collaborations between Australian researchers and high profile world experts in the area of the proposal. It will create an opportunity for a Ph.D. graduate to be involved in top-class research as a Research Associate, and will attract Ph.D. and honours students thus enabling research training in a high-quality mathematical environment.Read moreRead less
Symmetry and geometric structures. This is a fundamental research project in mathematics, especially concerned with the interaction between symmetry, differential equations, and geometry. Based on many classical and recently discovered instances, the aim of the project is to use symmetries to build and understand curved geometric structures from their flat counterparts.
Development Of Therapeutically Useful Human Artificial Chromosomes For Gene Delivery And Optimal Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$496,986.00
Summary
Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in ....Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in terms of infection, immune response, and germline modification. We have developed the first stage of a new technology for gene delivery that does not require the use of viruses. This technology is based on the generation of human artificial chromosomes, which are smaller versions of the naturally occurring chromosomes that carry all the genes inside our cells. Safety in these artificial chromosomes comes from the use of entirely human materials for their engineering. These artificial chromosomes also have other advantages over the viral approaches, including allowing large genes to be carried, and providing a permanent cure in a single treatment. We have already successfully constructed, published, and patented a number of first-generation human artificial chromosomes. The current project aims to complete the next proof-of-concept milestone towards the further development of this technology. Specifically, we propose to demonstrate the ability of the artificial chromosomes to carry genes and provide sustainable expression of these genes in cells and in animal models. Success in this study will allow the technology to proceed rapidly into commercialisation and clinical trial as a new improved tool for gene delivery and gene therapy.Read moreRead less
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Indigenous mathematical transforms. A class of mathematical transforms, or systematic conversions between related spaces or objects, was practised by some Aboriginal and Torres Strait Islander groups. Such transforms from ground to night sky were used in long-distance route-recording and wayfinding techniques. This project aims to elucidate these transforms, and to use this knowledge to extend the mathematical framework and applications of Fourier analysis. There is significant potential for new ....Indigenous mathematical transforms. A class of mathematical transforms, or systematic conversions between related spaces or objects, was practised by some Aboriginal and Torres Strait Islander groups. Such transforms from ground to night sky were used in long-distance route-recording and wayfinding techniques. This project aims to elucidate these transforms, and to use this knowledge to extend the mathematical framework and applications of Fourier analysis. There is significant potential for new mathematics to emerge at this exciting interface of Indigenous/non-Indigenous knowledge. Expected outcomes are interdisciplinary research training for Indigenous students and new understanding of Indigenous sciences. Emerging big data technologies such as holography may benefit. Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less