Enhancing Grain Yield Potential and Quality of Lupin. Sustainability of wheat production in Western Australia depends on the continued use of legumes, specifically lupins, in farming systems. The low returns to growers for lupins has jeopardised these sustainable systems. This project aims to gather new information to develop novel genetic strategies to increase yield potential and modify seed composition in lupins, enhancing their commercial worth.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347922
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Joint Facility for Plant Genetic Analysis and Gene Discovery in WA. This project will extend collaboration between Murdoch and UWA by provision of advanced facilities for plant genetic analysis and gene discovery. This will be achieved by purchase of novel equipment for discovery and analysis of single nucleotide polymorphisms (SNPs - single base changes between individual plants) that mark differences in their properties, and by purchase of equipment to underpin gene discovery and analysis of ....Joint Facility for Plant Genetic Analysis and Gene Discovery in WA. This project will extend collaboration between Murdoch and UWA by provision of advanced facilities for plant genetic analysis and gene discovery. This will be achieved by purchase of novel equipment for discovery and analysis of single nucleotide polymorphisms (SNPs - single base changes between individual plants) that mark differences in their properties, and by purchase of equipment to underpin gene discovery and analysis of expression. Provision of this equipment will enable full use of plant growth facilities now under construction, lead to advanced technologies of plant genetic analysis, and discovery of new basic information on fundamental plant processes.Read moreRead less
Using Systems Biology To Understand Asthma Exacerbations And Develop Better Treatments
Funder
National Health and Medical Research Council
Funding Amount
$791,734.00
Summary
Our research using cutting-edge technology has demonstrated that not all asthma attacks are the same. There are two major subtypes of asthma attacks. Currently, we use the same medication to treat all asthma attacks, and this medication targets the symptoms rather than the cause. This research will conduct detailed laboratory studies to understand what causes the two different types of asthma attacks, and test new treatments that are targeted and tailored to each type of asthma attack.
Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will gre ....Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will greatly improve the reliability (and hence cost) of future foundation and basement designs in Perth and elsewhere.Read moreRead less
Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches ....Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches and wave barriers to dissipate wave propagation, and in structural engineering to estimate in-structure vibration level and design isolators for sensitive equipment housed within. The technique will involve fundamental advances in the scaled boundary finite-element method, as calculations will be performed in a moving reference frame.Read moreRead less
Future Proofing Transportation Infrastructure Assets. This project seeks to develop a model to predict construction project overruns. Transportation infrastructure assets are prone to cost and schedule overruns during their construction, which have negative impacts on asset owners and users. This project aims to develop a systemic model that can be used to determine the causal nature of cost and schedule overruns and their probability of occurrence. By enabling the predication of overruns, the p ....Future Proofing Transportation Infrastructure Assets. This project seeks to develop a model to predict construction project overruns. Transportation infrastructure assets are prone to cost and schedule overruns during their construction, which have negative impacts on asset owners and users. This project aims to develop a systemic model that can be used to determine the causal nature of cost and schedule overruns and their probability of occurrence. By enabling the predication of overruns, the project aims to ensure that the public and private sector are able to put in place mitigation strategies to reduce the impact of the economic and productivity issues that arise due to overruns.Read moreRead less
Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of th ....Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of the host-pathogen interactions. A successful outcome could contribute an additional 5-20% increase in crop yields (depending on the crop) through inherent resistance of crops to nematode pests. This would benefit rural communities and the national economy, and could also generate international royalties.Read moreRead less