Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation ....Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation of results. While theoretical developments of this project are general, in the sense that they are not restricted to particular engineering disciplines, the four chosen applications closely align with two major research priorities namely An Environmental Sustainable Australia and Promoting and Maintaining Good Health.Read moreRead less
Design guideline for suction caissons supporting offshore wind turbines. This project aims to develop an industry guideline for suction caisson foundations, that are a new form of fixed platform anchor, for offshore wind turbines. The project expects to generate new knowledge of caisson response during installation and over millions of wind/wave load cycles, by integrating field experience with measurements from innovative experiments. The expected outcomes of this project include new methods to ....Design guideline for suction caissons supporting offshore wind turbines. This project aims to develop an industry guideline for suction caisson foundations, that are a new form of fixed platform anchor, for offshore wind turbines. The project expects to generate new knowledge of caisson response during installation and over millions of wind/wave load cycles, by integrating field experience with measurements from innovative experiments. The expected outcomes of this project include new methods to guide suction installation in difficult soil layering and predicting rotation and stiffness over a turbine’s operational life. The benefits of these scientific advances will contribute to the economic and reliable design of suction caisson foundations and a more rapid take-up of offshore wind energy.Read moreRead less
Crusty Seabeds: From (Bio-)Genesis To Reliable Offshore Design. The project aims to make deep water oil and gas developments safer and cheaper by understanding better the unique seabed ‘crust’ conditions that occur in Australian waters. By studying the biogenic, structural and mechanical properties of deepwater crusts in more detail than can be done in ‘live’ oil and gas projects, this project expects to make a step change in the understanding of these seabed crusts. Expected outcomes of this pr ....Crusty Seabeds: From (Bio-)Genesis To Reliable Offshore Design. The project aims to make deep water oil and gas developments safer and cheaper by understanding better the unique seabed ‘crust’ conditions that occur in Australian waters. By studying the biogenic, structural and mechanical properties of deepwater crusts in more detail than can be done in ‘live’ oil and gas projects, this project expects to make a step change in the understanding of these seabed crusts. Expected outcomes of this project include developing new seabed investigation and design approaches for these soils. This should provide significant benefits, by facilitating the design and installation of low-risk, yet low cost seabed infrastructure (e.g. pipelines, risers, shallow foundations etc.) in these problematical seabed typesRead moreRead less
Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material fail ....Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material failure associated with the high impact forces. Expected outcomes of the project include a conceptual framework and scientific-based design tool to predict the geotechnical performance of offshore installations. The research will provide the necessary scientific advances to install, moor and service offshore wind and wave energy devices more economically and efficiently.Read moreRead less