Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magneto ....The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. Based on our preliminary investigations, which suggest that the activity of bacterial MS channels may be affected by magnetic fields, we propose to study effects of magnetic fields on MS ion channels in Gram-negative bacteria Escherichia coli and Magnetospirillum magnetotacticum. The project promises also to contribute towards better understanding of adverse effects of electromagnetic radiation on human health and towards understanding the mechanisms behind remote magnetic-nanoparticle mediated activation of MS ion channels.Read moreRead less
New Silent Anchors for Floating Offshore Wind Turbines in Calcareous Sand . Reliable wind energy sites are in deeper waters and require offshore floating structures to harness the wind energy. Such floating structures require a reliable anchoring system that is secure and environmentally friendly. Calcareous sands, rich in carbonate content, pose unique challenges with their behaviour difficult to predict. In this project, a novel silent anchoring system is investigated that can be installed wit ....New Silent Anchors for Floating Offshore Wind Turbines in Calcareous Sand . Reliable wind energy sites are in deeper waters and require offshore floating structures to harness the wind energy. Such floating structures require a reliable anchoring system that is secure and environmentally friendly. Calcareous sands, rich in carbonate content, pose unique challenges with their behaviour difficult to predict. In this project, a novel silent anchoring system is investigated that can be installed with minimum noise and vibration compared to more traditional counterparts. Through the state of the art development in numerical modelling and centrifuge modelling, this project will advance Australian Science and Practice in designing floating wind turbines in carbonate rich soils offshore and help energy transition.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less
Improving road network operations under non-recurrent events. This project aims to develop an innovative approach for improving Road Network Operations (RNO) under non-recurrent events through analysis of big data and images. The outcomes of this project can not only improve the mobility of people, but also provide improved safety outcomes for all users of the transport network. It will help optimise traffic control strategies and traffic designs, reduce the maintenance cost for road infrastruc ....Improving road network operations under non-recurrent events. This project aims to develop an innovative approach for improving Road Network Operations (RNO) under non-recurrent events through analysis of big data and images. The outcomes of this project can not only improve the mobility of people, but also provide improved safety outcomes for all users of the transport network. It will help optimise traffic control strategies and traffic designs, reduce the maintenance cost for road infrastructure and improve quality of life.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100006
Funder
Australian Research Council
Funding Amount
$3,937,625.00
Summary
ARC Training Centre for Advanced Technologies in Rail Track Infrastructure. The ARC Training Centre for Advanced Technologies in Rail Track Infrastructure aims to transform Australia’s rail construction and maintenance technologies through specialist training of industry-focused researchers. Generation of new knowledge and close collaboration with companies within the rail supply chain will result in enhanced rail capacity and supply chain efficiency across the rail network. This will include in ....ARC Training Centre for Advanced Technologies in Rail Track Infrastructure. The ARC Training Centre for Advanced Technologies in Rail Track Infrastructure aims to transform Australia’s rail construction and maintenance technologies through specialist training of industry-focused researchers. Generation of new knowledge and close collaboration with companies within the rail supply chain will result in enhanced rail capacity and supply chain efficiency across the rail network. This will include increased axle loads and higher speeds, greater safety margins, reduced construction and maintenance costs, and a body of competent railway professionals in the nation’s work force.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100053
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an underst ....State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an understanding of the various methods available, and their capabilities and limitations, through systematic research projects. Very little research has been done in Australia and overseas in this area due to lack of facilities. This state-of-the-art testing equipment will provide Australian institutions with a cutting edge facility with portable equipment for NDT related research.Read moreRead less