Identification of genes controlling wood fibre properties in Eucalyptus nitens. Australian forestry is shifting to high intensity eucalypt plantations and increasingly focussing on development of breeds and clones with superior wood and pulp traits. Many of these traits are under moderate to strong genetic control and DNA markers have helped identify regions on eucalypt chromosomes that influence these traits. This project aims to identify the genes at these chromosomal locations that influence ....Identification of genes controlling wood fibre properties in Eucalyptus nitens. Australian forestry is shifting to high intensity eucalypt plantations and increasingly focussing on development of breeds and clones with superior wood and pulp traits. Many of these traits are under moderate to strong genetic control and DNA markers have helped identify regions on eucalypt chromosomes that influence these traits. This project aims to identify the genes at these chromosomal locations that influence wood fibre development and which have a strong influence on major commercial traits. The project will increase our understanding of wood and fibre development in eucalypts, and facilitate development of genetic markers to track superior genes during breeding.Read moreRead less
Modulation of protein folding pathways: a new platform technology for molecular medicine. Misfolding of proteins is becoming recognised as a major cause of inherited disease. We propose to develop a chemical agent that will optimise the folding of alpha1-antitrypsin (AAT), misfolding of which gives rise to inheritable liver and lung disease. This agent will have potential application as a therapy for sufferers of AAT-misfolding disease and for improving the yield of AAT purified from human plasm ....Modulation of protein folding pathways: a new platform technology for molecular medicine. Misfolding of proteins is becoming recognised as a major cause of inherited disease. We propose to develop a chemical agent that will optimise the folding of alpha1-antitrypsin (AAT), misfolding of which gives rise to inheritable liver and lung disease. This agent will have potential application as a therapy for sufferers of AAT-misfolding disease and for improving the yield of AAT purified from human plasma, which is the current agent used to treat patients with AAT-misfolding disease.Read moreRead less
Toward novel approaches for the control of parasitic nematodes via genomics/phenomics. The control of economically important parasitic worms of livestock relies heavily on the use of chemical compounds (anthelmintics). Their excessive and uncontrolled use has led to serious anthelmintic resistance problems in parasites, so that many treatments are no longer effective, and also to residue problems in meat, milk and the environment. We will use 'cutting edge' technologies to provide unique insight ....Toward novel approaches for the control of parasitic nematodes via genomics/phenomics. The control of economically important parasitic worms of livestock relies heavily on the use of chemical compounds (anthelmintics). Their excessive and uncontrolled use has led to serious anthelmintic resistance problems in parasites, so that many treatments are no longer effective, and also to residue problems in meat, milk and the environment. We will use 'cutting edge' technologies to provide unique insights into the molecular processes of parasite growth and reproduction, to develop safe and sustainable intervention strategies for parasites. The project will provide a unique technology platform and a skills base in parasite genomics and will generate significant intellectual property.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key para ....Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key parameters involved in the improvement of subgrade soil by injecting lime-flyash slurry. This project will develop an improved design procedure for lime-flyash slurry injection in the field based on experimental and numerical modelling.Read moreRead less
Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assem ....Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assemblages in a controlled environment, and comprehensive analytical modelling of both loading and response. The outcomes from this research will have direct application to the mining, insurance, construction and defence industries.Read moreRead less
preventing reoccurrence of catastrophic failures of stormwater pipelines. This project aims to develop a technique to accurately predict the remaining safe life of deteriorated buried stormwater pipelines, thereby preventing their catastrophic failure. The research also aims to advance knowledge in deterioration science of reinforced concrete and failure theory of buried pipes. The outcomes are anticipated to be a suite of rational, practical and validated models for pipe deterioration as measur ....preventing reoccurrence of catastrophic failures of stormwater pipelines. This project aims to develop a technique to accurately predict the remaining safe life of deteriorated buried stormwater pipelines, thereby preventing their catastrophic failure. The research also aims to advance knowledge in deterioration science of reinforced concrete and failure theory of buried pipes. The outcomes are anticipated to be a suite of rational, practical and validated models for pipe deterioration as measured by crack growth and residual strength which are integrated in a time-dependent reliability method and coded as a computer program ready for take-up by end-users. Preventing catastrophic failures of buried pipes should deliver economic, environmental and social benefits.Read moreRead less
Improvement of the performance of water-sensitive geomaterials using hydrophobic additives. Geo-structures such as road and railway bases suffer from water induced damage because they readily interact with the atmosphere and shallow water tables. Under traffic loading, damage to geo-structures occurs as cracking, rutting and roughness, when the strength and stiffness of the geomaterials are compromised by on-going moisture variations. Substantial cost savings to the community can be made if ef ....Improvement of the performance of water-sensitive geomaterials using hydrophobic additives. Geo-structures such as road and railway bases suffer from water induced damage because they readily interact with the atmosphere and shallow water tables. Under traffic loading, damage to geo-structures occurs as cracking, rutting and roughness, when the strength and stiffness of the geomaterials are compromised by on-going moisture variations. Substantial cost savings to the community can be made if effective methods can be found to minimise such damage. This project proposes to study a novel technique, in which blends of hydrophobic polymer additives are used to increase the stability of geomaterials subjected to varying moisture levels and traffic loading.Read moreRead less
Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city enviro ....Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city environments. Expected outcomes include an effective pipe burst early warning system and the implementation of an active burst prevention and targeted pipe replacement strategy. This should significantly reduce the burst rates and associated interruptions in Adelaide and save millions of dollars every year in pipe relay programs.Read moreRead less
Rational lateral-bracing design for steel-framed domestic structures. For the 150,000 new Australian houses built annually to remain safe, despite expected increases in structural loading due to climate change, rational design approaches are desperately needed. This project will provide the industry with the necessary tools to develop optimised and innovative solutions to brace houses for extreme events and yet maintain affordability.