Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100006
Funder
Australian Research Council
Funding Amount
$3,937,625.00
Summary
ARC Training Centre for Advanced Technologies in Rail Track Infrastructure. The ARC Training Centre for Advanced Technologies in Rail Track Infrastructure aims to transform Australia’s rail construction and maintenance technologies through specialist training of industry-focused researchers. Generation of new knowledge and close collaboration with companies within the rail supply chain will result in enhanced rail capacity and supply chain efficiency across the rail network. This will include in ....ARC Training Centre for Advanced Technologies in Rail Track Infrastructure. The ARC Training Centre for Advanced Technologies in Rail Track Infrastructure aims to transform Australia’s rail construction and maintenance technologies through specialist training of industry-focused researchers. Generation of new knowledge and close collaboration with companies within the rail supply chain will result in enhanced rail capacity and supply chain efficiency across the rail network. This will include increased axle loads and higher speeds, greater safety margins, reduced construction and maintenance costs, and a body of competent railway professionals in the nation’s work force.Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
Seismic analysis of cracking and deformations in concrete gravity dams. This project aims to establish a rational predictive capability for the responses of concrete gravity dams subject to extreme design earthquakes. This will include the development of innovative numerical methods for effective modelling of crack propagation and closure, large slips on crack faces and weak interfaces, dam-reservoir interaction, dam-foundation interaction and automatic mesh generation. The expected outcomes of ....Seismic analysis of cracking and deformations in concrete gravity dams. This project aims to establish a rational predictive capability for the responses of concrete gravity dams subject to extreme design earthquakes. This will include the development of innovative numerical methods for effective modelling of crack propagation and closure, large slips on crack faces and weak interfaces, dam-reservoir interaction, dam-foundation interaction and automatic mesh generation. The expected outcomes of the project will be a significantly improved prediction tool. It is also anticipated that the project will result in improvements in dam and public safety, and more efficient use of funds for dam safety upgrades and management.Read moreRead less
Microbiologically Induced Stress Corrosion Cracking in Underground Mines. Premature brittle failure of rock & cable bolts due to stress corrosion cracking can cause fatalities and serious damage, and has been reported in several mining operations across Australia and world-wide. The evidence suggests that microbial activity is a contributing factor. The project aims to implement experimental methodologies to determine the specific conditions responsible for bolt failure and develop novel prevent ....Microbiologically Induced Stress Corrosion Cracking in Underground Mines. Premature brittle failure of rock & cable bolts due to stress corrosion cracking can cause fatalities and serious damage, and has been reported in several mining operations across Australia and world-wide. The evidence suggests that microbial activity is a contributing factor. The project aims to implement experimental methodologies to determine the specific conditions responsible for bolt failure and develop novel prevention techniques applicable in underground mines. The benefits of this research will be improved understanding of the environment causing catastrophic failure of bolts and avoidance of potential hazards & economic loss in mining projects. This will lead to improved safety & increased productivity in mining operations.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less