Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a mo ....Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.Read moreRead less
The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Austr ....The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Australians who inherit Hartnup disorder with a better understanding of this disease by enabling individuals and families to make choices that lead to healthy, productive and fulfilling lives.Read moreRead less
Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polym ....Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polymer chain and the molecular weight distribution. The project will result in the preparation of functional polymers containing a specific arrangement of monomers in the polymer chain and a precise distribution of polymer chains. The development of such process will result in the development of advanced materials.Read moreRead less
Manufacturing Nanostructured Polymer Thin Films using Visible Light. This research aims the development of selective photochemical tools driven by different colours of light for the fabrication of nanostructured polymer brush thin films. By using different wavelengths to selectively activate specific chemical reactions, this will enable multiple reactions to be performed simultaneously, significantly streamlining fabrication. Additionally, the increased selectivity offers pathways to more sophis ....Manufacturing Nanostructured Polymer Thin Films using Visible Light. This research aims the development of selective photochemical tools driven by different colours of light for the fabrication of nanostructured polymer brush thin films. By using different wavelengths to selectively activate specific chemical reactions, this will enable multiple reactions to be performed simultaneously, significantly streamlining fabrication. Additionally, the increased selectivity offers pathways to more sophisticated nanoarchitectures in comparison to existing methods. This research will lead to the fabrication of 3D polymer brush architectures with unparalleled precision, which will be of high scientific and industrial value for a diverse range of applications, such as optoelectronics, nanoactuation, and sensing.Read moreRead less
Reactive flow through porous media by micro-imaging. Australia is embarking on the development of major gas fields offshore Western Australia. These developments are very costly and techniques to manage the risk in development are well sought after. This project assists in risk management of tertiary recovery methods and CO2 storage. Further, it can contribute significantly to the accurate forward modelling of storage of hazardous materials and pollution remediation strategies. The project could ....Reactive flow through porous media by micro-imaging. Australia is embarking on the development of major gas fields offshore Western Australia. These developments are very costly and techniques to manage the risk in development are well sought after. This project assists in risk management of tertiary recovery methods and CO2 storage. Further, it can contribute significantly to the accurate forward modelling of storage of hazardous materials and pollution remediation strategies. The project could shape important decisions in the future and impact on environmental risk assessment.Read moreRead less
Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive econom ....Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive economic opportunity. However, the high flammability and low ignition energy of hydrogen makes it vulnerable to accidental explosions. Hence, this project will address the lack of safety protocols in Australian Standards related to the handling of hydrogen by producing essential design recommendations.Read moreRead less
Optimisation methods for coherent quantum signal estimation and filtering. The project aims to develop an innovative systems theory and optimisation methods to enhance the design of components for next-generation quantum communication networks. It will advance new theoretical knowledge and efficient algorithms that can be applied to make networks more efficient and less costly. New technologies set to emerge within the next decade including specialised quantum processors and transformative cyber ....Optimisation methods for coherent quantum signal estimation and filtering. The project aims to develop an innovative systems theory and optimisation methods to enhance the design of components for next-generation quantum communication networks. It will advance new theoretical knowledge and efficient algorithms that can be applied to make networks more efficient and less costly. New technologies set to emerge within the next decade including specialised quantum processors and transformative cyber security systems will require ultra-fast networks, and the project will contribute significantly to advancing these technologies. This will benefit the Australia's economy and reinforce Australia's leadership in the quantum technological revolution through innovative engineering approaches.Read moreRead less
Assessing reservoir performance for carbon storage in saline aquifers. This project aims to develop a multiscale framework of site characterisation for carbon storage in deep saline aquifers and calculate measures of injectivity, storage capacity and containment. Carbon capture and storage could reduce carbon emissions within two decades. Carbon dioxide emissions are the most important drivers of climate change, with detrimental effects on humans and their environment, including water security, ....Assessing reservoir performance for carbon storage in saline aquifers. This project aims to develop a multiscale framework of site characterisation for carbon storage in deep saline aquifers and calculate measures of injectivity, storage capacity and containment. Carbon capture and storage could reduce carbon emissions within two decades. Carbon dioxide emissions are the most important drivers of climate change, with detrimental effects on humans and their environment, including water security, agriculture, coastal communities, and infrastructure. This project will improve assessment of reservoir performance for carbon storage in saline aquifers, and help reduce carbon emissions.Read moreRead less
Multiscale modelling of multiphase interactions in shale gas reservoirs. As conventional oil and gas become depleted in most of the producing basins, extraction of unconventional gas trapped in shale formations needs to become more viable. Since Australian shales have different characteristics from North American ones, the existing knowledge cannot be directly applied. We aim to develop a novel multiscale framework for deep understanding of the complex multiphase interactions in shale gas reserv ....Multiscale modelling of multiphase interactions in shale gas reservoirs. As conventional oil and gas become depleted in most of the producing basins, extraction of unconventional gas trapped in shale formations needs to become more viable. Since Australian shales have different characteristics from North American ones, the existing knowledge cannot be directly applied. We aim to develop a novel multiscale framework for deep understanding of the complex multiphase interactions in shale gas reservoirs. The outcomes will not only enable us to effectively assess the viability of gas extraction from Australian shale reservoirs with accurate long-term production forecasting, but help to develop strategies to effectively extract this relatively low carbon-emitting fossil fuel in the transition to a renewable economy.Read moreRead less