Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will im ....Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will improve our mechanistic understanding of genetic diseases in populations. In addition, this proposal is expected to lead to identification of potential targets and technologies that would be of interest to Australian industry.Read moreRead less
Genetic analysis of cohesin function and regulation in Drosophila. In yeast, a multiprotein complex, called cohesin, holds newly replicated chromatids together until the cell is ready to partition each chromatid into its daughter cells. We and others have shown that cohesins are regulated differently in animal cells. We propose to combine classical genetic analyses with two new and innovative techniques, time-lapse confocal microscopy of fluorescent proteins in living cells and gene-specific kno ....Genetic analysis of cohesin function and regulation in Drosophila. In yeast, a multiprotein complex, called cohesin, holds newly replicated chromatids together until the cell is ready to partition each chromatid into its daughter cells. We and others have shown that cohesins are regulated differently in animal cells. We propose to combine classical genetic analyses with two new and innovative techniques, time-lapse confocal microscopy of fluorescent proteins in living cells and gene-specific knockout techniques to study key cohesin regulators in Drosophila. These studies will provide us with novel insights into how multicellular organisms regulate the structure and stability of their chromosomes.Read moreRead less
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommenda ....Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommendations to support the transition of insecure replacement teachers within the profession. The benefits of this research include, improving teachers’ classroom management practices; the retention of new teachers; improving teacher workforce development; and building a healthier education system. Read moreRead less
Naming the world: early years literacy and sustainability learning. The project seeks to produce knowledge about new forms of literacy emerging in sustainability education. For children born in the 21st century, the enmeshing of natural and human forces in the survival of the planet requires conceptual and practical innovation. Early childhood education can be a fundamental driver in this process. This project aims to integrate literacy and sustainability to produce powerful new learning for you ....Naming the world: early years literacy and sustainability learning. The project seeks to produce knowledge about new forms of literacy emerging in sustainability education. For children born in the 21st century, the enmeshing of natural and human forces in the survival of the planet requires conceptual and practical innovation. Early childhood education can be a fundamental driver in this process. This project aims to integrate literacy and sustainability to produce powerful new learning for young children. It plans to theorise new forms of literacy emerging in sustainability education, articulate innovative pedagogies, and inform national and international policy and practice to address 21st century learning imperatives.Read moreRead less
Education meets play: a sociological study of how the new compulsory national learning framework for children zero to five years influences educators' practice. New theorising about play and education in early childhood settings has challenged traditional notions of play. This project investigates how educators respond to the requirement for play-based learning by identifying characteristics of successful educators and professional leaders, and strategies and practices that merge education and p ....Education meets play: a sociological study of how the new compulsory national learning framework for children zero to five years influences educators' practice. New theorising about play and education in early childhood settings has challenged traditional notions of play. This project investigates how educators respond to the requirement for play-based learning by identifying characteristics of successful educators and professional leaders, and strategies and practices that merge education and play.Read moreRead less
Social justice dispositions informing teachers' pedagogy in advantaged and disadvantaged secondary schools. This project studies the different perspectives that teachers have towards social justice and how these differently influence their teaching in advantaged and disadvantaged secondary schools. It will produce new concepts and methods for researching educational inequalities and to better enable teachers to act in more socially just ways.
Learning-rich leadership for quality improvement in early education. This project aims to establish Australia's first evidence base to inform quality improvement in early childhood education services through the development of educational leaders. Effective leadership is essential to ensuring the effective implementation of the Australian government's national quality standards for early childhood education. A new theory of 'learning-rich' leadership for quality improvement will be developed to ....Learning-rich leadership for quality improvement in early education. This project aims to establish Australia's first evidence base to inform quality improvement in early childhood education services through the development of educational leaders. Effective leadership is essential to ensuring the effective implementation of the Australian government's national quality standards for early childhood education. A new theory of 'learning-rich' leadership for quality improvement will be developed to influence leadership education in the early childhood sector. Expected outcomes from this project have potential benefits for the increased effectiveness in service quality for early childhood education.Read moreRead less
Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an ....Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an 'ideal' PE ecosystem that values re-specialisation in the core subjects; and develop principles to inform policy and practice needed to attain this ideal. The evidence-based framing of PE will inform efforts by schools, PE providers and policy makers to sustain a highly capable, adaptive and specialised teaching workforce.Read moreRead less
Teacher attraction and retention in hard-to-staff schools. Australia is facing a teacher shortage crisis. Many schools have become ‘hard-to-staff’ – evident through either a lack of teachers or a high teacher turnover. The aim of this project is to provide the foundations for strategies that can be implemented by schools and systems to address this problem. Due to the schools’ locations, these shortages can have severe consequences for already educationally vulnerable young people. This has been ....Teacher attraction and retention in hard-to-staff schools. Australia is facing a teacher shortage crisis. Many schools have become ‘hard-to-staff’ – evident through either a lack of teachers or a high teacher turnover. The aim of this project is to provide the foundations for strategies that can be implemented by schools and systems to address this problem. Due to the schools’ locations, these shortages can have severe consequences for already educationally vulnerable young people. This has been a significant concern of governments nationally and internationally. An important outcome from the project will be how best to attract and retain teachers in hard-to-staff schools. This will have benefits for the teaching profession, young people who attend hard-to-staff schools and the broader community. Read moreRead less