Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
Investigations into the Versatility of Peptide Nucleic Acid Conjugates. Neurodegeneration and cancer are two of the greatest frontiers in modern medicine. They impose significant medical, financial and social burdens on sufferers, carers and the wider community. Novel technologies with the ability to help diagnosis, enlighten researchers to the biological principles governing the disease and that can make a contribution to prevention, quality of life issues and survival of sufferers are of utmos ....Investigations into the Versatility of Peptide Nucleic Acid Conjugates. Neurodegeneration and cancer are two of the greatest frontiers in modern medicine. They impose significant medical, financial and social burdens on sufferers, carers and the wider community. Novel technologies with the ability to help diagnosis, enlighten researchers to the biological principles governing the disease and that can make a contribution to prevention, quality of life issues and survival of sufferers are of utmost importance. This project aims to make a significant contribution to these areas using antisense technologies against some previously studied targets.Read moreRead less