Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775587
Funder
Australian Research Council
Funding Amount
$532,000.00
Summary
Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions ....Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions in health and disease, providing both community and national benefits. The focus of this LIEF application is to provide infrastructure platforms for the study of the systems biology of organisms and additional capacity by the facility for the expected increased demand for this technology in this new area. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347245
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Functional Genomics Analysis - linking a multicentred facility. The aim of this project is to enhance and network the functions and activities of the Clive and Vera Ramaciotti Centre for Gene Function Analysis (CGRCGFA), a joint venture that services five major universities in the Sydney-Newcastle area. This application is for equipment that will improve the speed of DNA analyses, and for a laboratory information management system that will standardise the handling of data and sample information ....Functional Genomics Analysis - linking a multicentred facility. The aim of this project is to enhance and network the functions and activities of the Clive and Vera Ramaciotti Centre for Gene Function Analysis (CGRCGFA), a joint venture that services five major universities in the Sydney-Newcastle area. This application is for equipment that will improve the speed of DNA analyses, and for a laboratory information management system that will standardise the handling of data and sample information at all nodes of the CVRCGFA.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0232455
Funder
Australian Research Council
Funding Amount
$545,000.00
Summary
The Molecular Analysis of Variation and Gene Function. The aim of this project is to establish the nodes of the Clive and Vera Ramaciotti Centre for Gene Function Analysis (CVRCGFA) which is a joint venture that serves the five major universities and three Institutes in the Sydney-Newcastle region. The primary focus of this application is to create new facilities at the hubs of CVRCFGA that are integral to the analysis of molecular variation in a range of organisms. The study of molecular vari ....The Molecular Analysis of Variation and Gene Function. The aim of this project is to establish the nodes of the Clive and Vera Ramaciotti Centre for Gene Function Analysis (CVRCGFA) which is a joint venture that serves the five major universities and three Institutes in the Sydney-Newcastle region. The primary focus of this application is to create new facilities at the hubs of CVRCFGA that are integral to the analysis of molecular variation in a range of organisms. The study of molecular variation will enable researchers to understand better how organisms interact with each other, how they respond to environmental stress and aid in the identification of complez traits.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453724
Funder
Australian Research Council
Funding Amount
$532,824.00
Summary
Functional Genomics - Linking Genomics and Proteomics. This application is to enhance the capacity of the Ramaciotti Centre for Gene Function Analaysis (RCFGA) and its Nodes to support research in Functional Genomics by expanding its ability to link genomic analysis (including transcriptomics) with proteomic and cell biological analysis. It will provide access to novel methods for analysing interactions of proteins with other molecules by enabling the manufacture of protein arrays as well as DN ....Functional Genomics - Linking Genomics and Proteomics. This application is to enhance the capacity of the Ramaciotti Centre for Gene Function Analaysis (RCFGA) and its Nodes to support research in Functional Genomics by expanding its ability to link genomic analysis (including transcriptomics) with proteomic and cell biological analysis. It will provide access to novel methods for analysing interactions of proteins with other molecules by enabling the manufacture of protein arrays as well as DNA microarrays and to analyse the data obtained from them. This is a vital component to maintain gene function analysis at the cutting edge of current technology.Read moreRead less
Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will im ....Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will improve our mechanistic understanding of genetic diseases in populations. In addition, this proposal is expected to lead to identification of potential targets and technologies that would be of interest to Australian industry.Read moreRead less