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Research Topic : gene array
Australian State/Territory : VIC
Scheme : Discovery Early Career Researcher Award
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Gene Expression (incl. Microarray and other genome-wide approaches) (8)
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  • Researchers (9)
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  • Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE120102575

    Funder
    Australian Research Council
    Funding Amount
    $375,000.00
    Summary
    Exploring new territory in climatic adaptation research: integrating molecular genetics with species' thermal tolerance limits. Predicting species' responses to environmental change requires mechanistic links between whole-organism physiological stress responses and underlying cellular mechanics. This project integrates cutting-edge methods in molecular and evolutionary genetics to probe species' responses to environmental change in the context of a warming environment.
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    Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE150100652

    Funder
    Australian Research Council
    Funding Amount
    $345,000.00
    Summary
    Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is h .... Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is how the balance between self-renewal and differentiation is regulated in these cells, nor how the control of this fate decision impacts on optimal organ development. This project aims to dissect the molecular identity, regulation, and influence of this stem cell population on kidney development.
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    Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE190100085

    Funder
    Australian Research Council
    Funding Amount
    $414,864.00
    Summary
    Elucidating a novel mechanism for coping with harmful mutations. This project aims to improve our understanding of the complex regulatory mechanisms that increase genetic and phenotypic robustness. Survival of organisms depends on their ability to cope with genetic variation. A novel process of genetic compensation has recently been identified, producing a normal phenotype in a homozygous mutant, that would be expected to have deleterious effects. This project will reveal how compensation is ach .... Elucidating a novel mechanism for coping with harmful mutations. This project aims to improve our understanding of the complex regulatory mechanisms that increase genetic and phenotypic robustness. Survival of organisms depends on their ability to cope with genetic variation. A novel process of genetic compensation has recently been identified, producing a normal phenotype in a homozygous mutant, that would be expected to have deleterious effects. This project will reveal how compensation is achieved by examining the molecular pathways that are activated following genetic mutation. This project is expected to strengthen Australian reputation in evolutionary genetics, and in turn enhance our understanding of how organisms adapt to changing environments.
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    Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE120100434

    Funder
    Australian Research Council
    Funding Amount
    $375,000.00
    Summary
    Estrogen-mediated regulation of gene expression via transcriptional and translational control: complementary, synergistic or opposing responses? Hormones dictate cellular behaviour by activating pre-programmed responses. The sex hormone estrogen affects cell fate by regulating the gene expression, but it is unknown to which extent this response occurs via activation of genes or control of already transcribed gene. The project will investigate how the cell integrates the complex estrogen signals.
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    Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE160101536

    Funder
    Australian Research Council
    Funding Amount
    $369,000.00
    Summary
    How does mitochondrial biogenesis regulate seed germination in plants? This project aims to develop a better understanding of seed germination to enable the generation of cereal seeds with optimised rates of germination for agricultural production. Seed germination is a fundamental phase of the plant life cycle. Every year, alterations in the rate of germination cause significant crop loss in rice and other cereals. Mitochondria are emerging as essential signalling hubs in the regulation of seed .... How does mitochondrial biogenesis regulate seed germination in plants? This project aims to develop a better understanding of seed germination to enable the generation of cereal seeds with optimised rates of germination for agricultural production. Seed germination is a fundamental phase of the plant life cycle. Every year, alterations in the rate of germination cause significant crop loss in rice and other cereals. Mitochondria are emerging as essential signalling hubs in the regulation of seed germination. The project aims to combine the latest technologies and molecular approaches with genetics to understand how mitochondria regulate seed germination and the rate of germination progression in rice. The project also plans to investigate and confirm the interplay between oxygen signalling, phytohormones and mitochondrial biogenesis.
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    Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE120100782

    Funder
    Australian Research Council
    Funding Amount
    $375,000.00
    Summary
    Identifying molecular regulators of haematopoietic stem cell development. Blood stem cells are capable of making all types of mature blood cell whilst making new copies of themselves. These properties are essential for the life-long supply of blood and make stem cells ideal for therapeutic use. By studying embryos, this project will identify genes that control the production and expansion of blood-forming stem cells.
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    Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE140101728

    Funder
    Australian Research Council
    Funding Amount
    $395,220.00
    Summary
    The regulation and evolution of posttranscriptional gene networks. The ability of cells to regulate gene expression is key for organism development, adaptation to new environments and evolutionary changes that shape the diversity of life on Earth. This project studies the RNA binding proteins called PUFs which are central for gene expression in diverse organisms. Using cutting-edge new generation systems biology approaches, this project will study how PUF proteins regulate genes to enable metabo .... The regulation and evolution of posttranscriptional gene networks. The ability of cells to regulate gene expression is key for organism development, adaptation to new environments and evolutionary changes that shape the diversity of life on Earth. This project studies the RNA binding proteins called PUFs which are central for gene expression in diverse organisms. Using cutting-edge new generation systems biology approaches, this project will study how PUF proteins regulate genes to enable metabolic adaptation, differentiation of cell types and the evolution of new gene expression outputs in distinct biological species. The outcomes will include new insights into the regulation and evolution of posttranscriptional gene networks.
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    Active Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE210100705

    Funder
    Australian Research Council
    Funding Amount
    $462,948.00
    Summary
    Decoding the enigmatic biology of human gamma-delta T cells. The immune system surveys our body examining molecules that signal whether or not everything is ok. T cells are a central to this and use their receptors to monitor these molecular signals. A specialised subset of T cells known as gamma-delta T cells are critical to detecting infection and cancer, yet their fundamental biology is poorly understood. This project aims to unravel this elusive biology. The aims are to understand 1. The div .... Decoding the enigmatic biology of human gamma-delta T cells. The immune system surveys our body examining molecules that signal whether or not everything is ok. T cells are a central to this and use their receptors to monitor these molecular signals. A specialised subset of T cells known as gamma-delta T cells are critical to detecting infection and cancer, yet their fundamental biology is poorly understood. This project aims to unravel this elusive biology. The aims are to understand 1. The diversity in function between gamma-delta T cell subsets, and 2. The diversity in gamma-delta T cell receptors and the molecules that these receptors detect. This work is essential for understanding gamma-delta T cell immunology which is critical if we ultimately wish to harness this to improve human health.
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    Showing 1-8 of 8 Funded Activites

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