Advanced optical tweezers technologies for biophysical measurements. While much is understood about the fundamental unit of life, the living cell, such as their behaviour and their biochemistry and genetics, the interface between these two is only poorly known. We will use optical tweezers, which can trap and move microscopic objects without physical contact, to measure forces on the molecular and cellular scale to study the mechanical properties of cells and biomolecules, including molecular mo ....Advanced optical tweezers technologies for biophysical measurements. While much is understood about the fundamental unit of life, the living cell, such as their behaviour and their biochemistry and genetics, the interface between these two is only poorly known. We will use optical tweezers, which can trap and move microscopic objects without physical contact, to measure forces on the molecular and cellular scale to study the mechanical properties of cells and biomolecules, including molecular motors, which are Nature's own nanomachines, advanced our knowledge of the fundamental machinery of life.Read moreRead less
Dynamic Force Microscopy of small molecular assemblies. The possibility of manipulating a single molecule seems at first unreal, indeed 5 years ago it was pure science fiction. Through the gaining popularity of the Atomic Force Microscope (AFM) many perspectives about the molecular world are changing. Macroscopic effects such as adhesion and lubrication are now discussed in light of measurements made with this instrument. Newer work includes the observation of single protein unfolding experim ....Dynamic Force Microscopy of small molecular assemblies. The possibility of manipulating a single molecule seems at first unreal, indeed 5 years ago it was pure science fiction. Through the gaining popularity of the Atomic Force Microscope (AFM) many perspectives about the molecular world are changing. Macroscopic effects such as adhesion and lubrication are now discussed in light of measurements made with this instrument. Newer work includes the observation of single protein unfolding experiments. The biophysics oriented project detailed in this application will extend the AFM: into multi-molecular systems formed by self-assembly, such as cell membranes; into polyelectrolyte-surface interactions; and, finally into the sequencing of DNA.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882382
Funder
Australian Research Council
Funding Amount
$245,000.00
Summary
Biophysical Characterisation Facility. The protein analysis facility will have substantial benefits for basic science and biotechnology. It will create capacity for South Australian researchers to study proteins at the biophysical level. The facility will support research projects within the designated national research priority areas of 'Frontier technologies for building and transforming Australian industries' and 'Promoting and maintaining good health
A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conduct ....A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conductance properties of the channel. Accurately
determining these relationships provides a pathway to developing cures
for many neurological, cardiac, and muscular diseases.
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The astrophysical stochastic background of gravitational waves and detection by advanced high optical power interferometers: an Australia-US collaboration. The proposed project is designed to enable one of the most exciting and least studied components of the gravitational wave spectrum, the Astrophysical Gravitational wave Background (AGB), to be detected by Advanced LIGO. It will extend the Australia-US collaboration in Advanced LIGO to include modeling, simulation and detection methods of the ....The astrophysical stochastic background of gravitational waves and detection by advanced high optical power interferometers: an Australia-US collaboration. The proposed project is designed to enable one of the most exciting and least studied components of the gravitational wave spectrum, the Astrophysical Gravitational wave Background (AGB), to be detected by Advanced LIGO. It will extend the Australia-US collaboration in Advanced LIGO to include modeling, simulation and detection methods of the AGB and the study of the optical noise in LIGO and Advanced LIGO type systems. In particular we plan to search for anomalous noise sources and, especially those arising in high optical power cavities that could limit detection of the AGB.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0228799
Funder
Australian Research Council
Funding Amount
$1,602,000.00
Summary
Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile, and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in way ....Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile, and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile and great public visibility in Galactic and extragalactic astronomy, and also to enhance the national capacity to construct advanced scientific instrumentation. Australia has already won a contract to build one of the instruments.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453817
Funder
Australian Research Council
Funding Amount
$1,849,438.00
Summary
Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to build and operate two 8-metre optical/infrared telescopes, one in Chile and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not ....Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to build and operate two 8-metre optical/infrared telescopes, one in Chile and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile and the great public visibility in Galactic and extragalactic astronomy, and also to enhance the national capacity to
construct advanced scientific instrumentation. Australia is currently building one of the instruments.
Note: in A7.1 GAMS incorrectly forces integer days/month. In full operation Australian astronomers will receive approximately 25 nights per year.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560761
Funder
Australian Research Council
Funding Amount
$1,458,000.00
Summary
Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium that operates two 8-metre optical/infrared telescopes, in Chile and Hawaii. Australia joined the IGP in 1998, with 4.76% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemi ....Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium that operates two 8-metre optical/infrared telescopes, in Chile and Hawaii. Australia joined the IGP in 1998, with 4.76% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile, and also to enhance the national capacity to construct advanced scientific instrumentation. Australian institutions are currently building two new instruments.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347237
Funder
Australian Research Council
Funding Amount
$1,855,121.00
Summary
Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways ....Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile and the great public visibility in Galactic and extragalactic astronomy, and also to enhance the national capacity to construct advanced scientific instrumentation. Australia is currently building one of the instruments.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668351
Funder
Australian Research Council
Funding Amount
$2,983,525.00
Summary
Australian Membership of the International Gemini Partnership. No science better captures public attention than astronomy. Through its membership of the international Gemini consortium that operates the Gemini telescopes, Australia has assured its astronomers of access to two of the finest large ground-based telescopes. Located in Hawaii and Chile, the telescopes enable Australian astronomers to pursue major questions such as how the universe evolved, the nature of dark matter and dark energy, h ....Australian Membership of the International Gemini Partnership. No science better captures public attention than astronomy. Through its membership of the international Gemini consortium that operates the Gemini telescopes, Australia has assured its astronomers of access to two of the finest large ground-based telescopes. Located in Hawaii and Chile, the telescopes enable Australian astronomers to pursue major questions such as how the universe evolved, the nature of dark matter and dark energy, how galaxies formed, and how stars and their planets formed. Australia has long been known for 'punching above its weight' in astronomy, and membership of Gemini is a vital step in assuring that this prominence in the field is maintained.Read moreRead less