ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $611,574.00
Summary: Over 80 million people have chronic constipation. It affects over 1/5 older people and is a major problem in aged-care. We have found that a painless method of electrical stimulation across the abdomen can overcome chronic constipation in children and adults. We will test the method to see what types of constipation it can help, including constipation caused by pain-medication and irritable bowel syndrome. This treatment is given at home and could improve life for many people around the world.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $543,301.00
Summary: The application of novel techniques to evaluate gastrointestinal motor function has established that the rate at which the stomach empties is abnormally slow in ~50% of people who have insulin-dependent (type 1) or non-insulin dependent (type 2) diabetes. Delayed stomach emptying, which was thought to be an infrequent complication of diabetes, may contribute to a number of problems including symptoms such as nausea and bloating, and poor control of blood glucose concentrations. The blood glucose ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $780,872.00
Summary: There is now increasing recognition that the stomach and intestines, by regulating the absorption of nutrients into the body and by releasing hormones that enhance insulin secretion, play a central role in the control of blood glucose in diabetes mellitus. We seek to understand the nature and causes of disturbed gut function in diabetes, so that we can optimise dietary and drug strategies to prevent and treat this condition.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $346,995.00
Summary: We have over 300 children with chronic treatment-resistant constipation at Royal Children's Hospital Melbourne. We have a new physiotherapy technique that may overcome constipation and stop soiling in many of these children. In 2003-4, we ran a pilot study to test a technique used by physiotherapists to treat urinary incontinence. We have called the method TESIC (transcutaneous electrical stimulation using interferential current). TESIC uses suction electrodes placed on the belly and back at the ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $487,990.00
Summary: This project aims to clarify the contractile patterns of the human colon which underlie the very common and distressing condition of constipation. We will be relating symptoms of constipation from a large number of sufferers with actual measurements of contractions along the colon in these patients. Furthermore by examining the in vivo colonic motor response to electrical stimulation of pelvic floor nerves, we will help to determine the potential of this new form of treatment for constipation. T ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $641,346.00
Summary: Bacterial pathogens are a major cause of illness and death, producing diseases ranging from acute infections to cancer. However, not all infected individuals will succumb to these pathologies. What factors dictate which individuals develop these diseases is an important complex question. The core focus of my research is the identification and characterisation of novel host factors that are involved in resistance or susceptibility to bacterial-associated diseases of the gastrointestinal tract.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $543,301.00
Summary: Pancreatic Cancer is the fourth leading cause of cancer death in men and women in Western societies. Nothing, apart from surgery in a small proportion of individuals gives any hope. The identification of novel treatment strategies in the modern era necessitates a rational scientific approach, where an understanding of the molecular mechanisms involved in the evolution of cancer underpins the development of such strategies in an efficient manner. Retinoids are derivatives of Vitamin A, and have b ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $892,661.00
Summary: I am a physiologist with expertise in endocrinology determining the roles of particular regulatory peptides in the normal functions of the gastrointestinal tract and in the development of gastrointestinal, renal and prostate cancers.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $523,523.00
Summary: Epithelial cell surface mucins are large complex proteins found on the surface of all mucosal epithelial tissues, for example in the respiratory, gastrointestinal, reproductive and urinary tracts. Most bacterial and viral pathogens enter the body via mucosal tissues. We have recently demonstrated that mucin proteins are a vital component of initial defence against mucosal pathogens. Defects in these proteins probably predispose individuals to common chronic infective and inflammatory diseases. T ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $495,433.00
Summary: Oesophageal adenocarcinoma (OAC) is the 6th commonest cause of cancer deaths in the Western World, and is increasing in incidence. In Australia most patients present late and require risky treatments with a low cure rate. There is a big difference in survival between individuals presenting early vs. late. Better methods to detect cancer early or detect pre-cancer will improve outcomes. Our research will develop a blood test for identifying individuals with early OAC to allow earlier treatment.

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