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T Helper Cytokines In Immunity And Organ-specific Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
The overall goal of these studies is to identify mechanisms underlying the effects of cytokines on T cell-mediated immunity, how defects in these processes can result in organ specific autoimmune disease, and whether exploiting these mechanisms may result in improved therapies for individuals with autoimmune diseases. The proposed aims build on my previous work on interleukin-21 and interleukin-21-producing T helper cells in both immunity and autoimmunity.
Intra- And Intercellular Spreading In Shigella Pathogenesis
Funder
National Health and Medical Research Council
Funding Amount
$216,318.00
Summary
Each year Shigella flexneri bacteria cause over 167 million episodes of dysentery and over 1 million deaths worldwide, under conditions of poor sanitation, in both developed and developing countries. No vaccines are available, and resistance to antibiotics is common. This project will study the a key part of the machinery that allows bacteria use to cause disease, and also to identify drugs that block the machinery which can in future be used to treat infection by these bacteria.