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Effects Of Dietary Amino And Fatty Acids On Energy Intake And Glycaemia - Implications For Novel Approaches To The Management Of Obesity And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$584,032.00
Summary
Current obesity treatments are limited in efficacy or have adverse effects. Our research has shown that specific fatty acids and amino acids markedly suppress energy intake and reduce blood glucose, without adverse effects. The goal of the proposed work is to evaluate the translational potential of these discoveries in obese diabetic patients. Ultimately, we hope to develop the findings from this research into novel, nutrient-based strategies for the management/prevention of obesity/diabetes.
Glucose is a critical fuel for living organisms and its presence in the gut triggers nerves that slow stomach emptying. However, little is known of how glucose is actually detected in the gut. We have established that sweet taste molecules of the tongue are also present in the gut, where they may detect glucose. This research will measure the expression and function of these molecules in the gut of humans and mice, and reveal key information on their potential as targets in health and disease.
Effects Of Gastric Bypass And Banding For Obesity On Gastrointestinal Function, Body Weight, Glycaemia And Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$444,086.00
Summary
The increasing incidence of obesity poses a significant impact on the health care system. Bariatric surgery not only achieves sustained weight loss but also reverses the associated complications. This proposal aims to examine the mechanisms that mediate weight loss, improvement in blood glucose control and symptoms after bariatric surgery. The results will provide insights into future development of minimally invasive interventions for the management of obesity and diabetes.
Bitter Taste As A Mediator Of Food Intake And Postprandial Glycaemia In Health And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$735,430.00
Summary
The gut “tastes” contents passing through it in a similar manner to the tongue. Recent evidence suggests that bitter substances in the gut can reduce appetite and slow the emptying of meals from the stomach, by stimulating gastrointestinal hormone release. We propose studies to understand how this system functions in health and type 2 diabetes, and whether it can be targeted to provide new diabetes treatments
Fat Sensing In The Gut: Role In Appetite Regulation In Health And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$391,076.00
Summary
Dr Little has an international reputation for her research relating to the sensing of nutrients in the gut. During the next 4 years her goal is to establish herself as an independent researcher leading a team and program focussed on characterising the molecular and physiological mechanisms by which fat is sensed in the gut, and the role of these mechanisms in energy intake regulation in health and obesity. These insights are likely to result in more effective management strategies for obesity.
Effects Of Dietary Protein On Gastrointestinal Function: Implications For The Regulation Of Energy Intake In Obesity
Funder
National Health and Medical Research Council
Funding Amount
$677,157.00
Summary
Obesity is largely due to energy intake exceeding energy expenditure. The CI has reported that dietary protein markedly reduces energy intake but the mechanisms underlying this effect remain unknown. The proposed studies will determine whether gastrointestinal mechanisms are involved in the regulation of appetite and energy intake and how they relate to body weight reduction in obese subjects. The research represents a unique approach to the management of obesity and health.