The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
A Trial Of Position Control Therapy For Treatment Of Infantile Gastro-oesophageal Reflux
Funder
National Health and Medical Research Council
Funding Amount
$533,290.00
Summary
Reflux of stomach contents into the gullet and mouth is a very common condition which interrupts feeding and sleep routine in infants. If reflux is not treated, more severe problems may manifest and patients may require anti-reflux surgery. Left-side positioning after feeding is the only non-drug approach proven to reduce the frequency of reflux in infants. This project will determine, by clinical trial, the role for left side positioning for reducing reflux related symptoms in infants.
Neuromodulation Of Triggering Of Transient Lower Oesophageal Sphincter Relaxation And Gastro-oesophageal Reflux
Funder
National Health and Medical Research Council
Funding Amount
$369,779.00
Summary
Reflux of stomach contents into the gullet is a very common condition. If reflux is not treated, more severe problems may manifest. In patients with reflux disease the anatomy of the junction between the gullet and the stomach is altered. This research program will undertake novel studies to explore how this alteration exacerbates the triggering reflux after a meal and potentially identify new targets for pharmacological therapy for this common problem.
Impact Of Oesophageal Afferent Processing On Regulatory And Protective Reflexes, And Perception Of Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$247,500.00
Summary
Symptoms of acid reflux, heartburn and regurgitation, are extremely common, occurring weekly in 20% of the population. Curiously, about 1-4 of people with heartburn don't have any more acid exposing their oesophagus than do normal people. We do not understand this apparent increased sensitivity. Many patients with reflux present with cough, asthma, hoarseness, sore throat or even lung fibrosis. Regurgitation of acid causes some of these conditions. It is estimated that 60% of adult asthmatics ha ....Symptoms of acid reflux, heartburn and regurgitation, are extremely common, occurring weekly in 20% of the population. Curiously, about 1-4 of people with heartburn don't have any more acid exposing their oesophagus than do normal people. We do not understand this apparent increased sensitivity. Many patients with reflux present with cough, asthma, hoarseness, sore throat or even lung fibrosis. Regurgitation of acid causes some of these conditions. It is estimated that 60% of adult asthmatics have reflux for example. The purpose of this research is to examine the notion that the sensory nerves coming from the oesophagus are somehow tuned up to fire off too readily. If true this phenomenon may well underlie the inappropriate relaxation of the oesophageal valve mechanisms that normally prevent acid flowing up into the throat and into the airways. Additionally it may explain why so many sufferers seem to be hypersensitive to even small amounts of acid. These studies will better define the nerve pathways involved in heartburn and regurgitation and help us target these diseases with specific drugs in the future.Read moreRead less
Pathophysiology And Treatment Of Pharyngo-oesophageal Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$168,275.00
Summary
A number of oral and respiratory tract diseases such as laryngitis, asthma, unexplained cough, sinusitis, and obstructive sleep apnoea, have been linked with gastroesophageal reflux disease. These particular respiratory complications carry significant morbidity and mortality. The mechanisms of regurgitation of gastric acid, via the oesophagus into the pharynx, are unknown. We have recently validated a novel technique to reliably detect acid regurgitation events into the pharynx. We propose to us ....A number of oral and respiratory tract diseases such as laryngitis, asthma, unexplained cough, sinusitis, and obstructive sleep apnoea, have been linked with gastroesophageal reflux disease. These particular respiratory complications carry significant morbidity and mortality. The mechanisms of regurgitation of gastric acid, via the oesophagus into the pharynx, are unknown. We have recently validated a novel technique to reliably detect acid regurgitation events into the pharynx. We propose to use this technique, combined with pressure recordings from the oesophagus and its valves, to determine the precise mechanisms underlying acid regurgitation into the throat. Such studies should lead to better means of treating these disorders.Read moreRead less