Understanding The Relationship Of Incretin Hormones, Gastric Emptying And Reactive Hypoglycaemia
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Low blood glucose levels following a meal occur frequently in otherwise healthy people and those who have had surgery for weight loss. It affects quality of life adversely and current management is unsatisfactory. The proposed studies will use sophisticated techniques to evaluate the roles of the rate of stomach emptying and the so-called 'incretin' hormones which stimulate the release of insulin after a meal. The outcomes will have major implications for more rational management.
Understanding the mechanisms in the development of mutations in cancers will assist in development of targeted therapies to overcome chemotherapy resistance. The recently discovered TMPRSS2:ERG fusion in prostate cancer is unique as dominant fusion translocations are uncommon in solid organ malignancy. Activation induced cytidine deaminase (AID) is thought to play a role. Understanding the role of AID and downstream DNA repair pathways may be a target for future therapies in cancer.
The Costs And Effectiveness Of New Anticancer Drugs
Funder
National Health and Medical Research Council
Funding Amount
$89,699.00
Summary
The general aim of this project is to assess new anticancer drugs and to determine what contributes to their cost, how well they work and their cost-effectiveness. Specific objectives include to systematically review recent evidence about the costs and cost-effectiveness of anticancer drugs, to perform cost-effectiveness analyses of expensive anticancer treatments based on data from clinical trials and to survey medical oncologists to determine their views on how treatment costs affect decision ....The general aim of this project is to assess new anticancer drugs and to determine what contributes to their cost, how well they work and their cost-effectiveness. Specific objectives include to systematically review recent evidence about the costs and cost-effectiveness of anticancer drugs, to perform cost-effectiveness analyses of expensive anticancer treatments based on data from clinical trials and to survey medical oncologists to determine their views on how treatment costs affect decision making.Read moreRead less
The Importance Of RUNX3 In Preventing Gastrointestinal Diseases And Tumour Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Stomach cancer is the second leading cause of cancer-related deaths. It is estimated that in 2010, more than 1 million people will die of stomach cancer with an increase of 19%. Studies have revealed that RUNX3 has the ability to suppress the growth of stomach cancer. However the role of RUNX3 in preventing metastasis is yet unknown. Therefore, an understanding of the factors that govern metastasis will inform the design of effective therapies to prevent mortality which is high for this disease.
Patient Safety And Therapeutic Implications Of A New Glucose Lowering Agent For Type 2 Diabetes And High Blood Glucose States In The Critically Ill
Funder
National Health and Medical Research Council
Funding Amount
$88,193.00
Summary
Dr Mark Plummer is a young intensive care trainee and scientist whose research activities are clinically based and relate primarily to the therapeutic implications of novel blood glucose lowering agents in diabetes and critical illness. He also has an interest into the effects of critical illness on upper gastrointestinal function. The results of these studies are expected to lead to safer drug regimens to control high blood sugar levels for diabetics in the community as well as in the intensive ....Dr Mark Plummer is a young intensive care trainee and scientist whose research activities are clinically based and relate primarily to the therapeutic implications of novel blood glucose lowering agents in diabetes and critical illness. He also has an interest into the effects of critical illness on upper gastrointestinal function. The results of these studies are expected to lead to safer drug regimens to control high blood sugar levels for diabetics in the community as well as in the intensive care unit.Read moreRead less