Arthritis of the big toe joint is a common and disabling problem in many Australians, but few effective treatments are available. This project will determine whether a combination of exercises and wearing a special shoe with a curved sole (a rocker-sole shoe) is more effective in treating this condition than exercises alone.
IMproving Physical ACtivity With Treadmill Training Following Stroke: The Stroke-IMPACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$736,065.00
Summary
Stroke is a leading cause of disability amongst Australians. After stroke, activity levels are low, with few people able to exercise at an intensity which will reduce the risk of future cardiovascular events. This project examines the effectiveness of combining a high intensity treadmill training program with a self management approach to improve activity levels, mobility, cardiovascular risk profile in stroke survivors, increasing their independence and reducing the burden of care.
INVESTIGATING PROPRIOCEPTION AND SENSORIMOTOR CONTROL IN HUMANS DEVOID OF FUNCTIONAL MUSCLE SPINDLES
Funder
National Health and Medical Research Council
Funding Amount
$335,983.00
Summary
Specific genetic mutations can lead to widespread changes in the body. Here we are looking at congenital Hereditary and Sensory Autonomic Neuropathy type III (HSAN III). Affected individuals have difficulty walking, which progressively worsens over time. This series of experiments aims to increase our understanding of the underlying neurophysiological disturbances in HSAN III.
Can Real-time Biofeedback Of Foot Clearance Data Be Used To Assist With Gait Rehabilitation Following Stroke?
Funder
National Health and Medical Research Council
Funding Amount
$587,143.00
Summary
A new intervention for falls-risk minimization is proposed by providing additional visual sensory information to increase foot-ground clearance in order to walk more safely.A randomised controlled trial will be employed to assess the effects of biofeedback on foot-ground clearance during gait training. The outcome will be innovative biofeedback-based gait training that could significantly enhance existing stroke rehabilitation programs.
A Computer-aided Diagnosis System For Gait Analysis
Funder
National Health and Medical Research Council
Funding Amount
$333,379.00
Summary
Gait analysis provides detailed information on how a patient walks to help orthopaedic surgeons decide on surgical treatments. However, gait analysis requires long and specific training and expertise in gait analysis is not widely available which restricts its benefits to the community. We will build the first computer-aided diagnosis system from renowned experts from The Royal Children’s Hospital Melbourne to assist clinicians interpreting gait analysis data nationally and internationally.
Improving Mobility After Traumatic Brain Injury With Ballistic Strength Training
Funder
National Health and Medical Research Council
Funding Amount
$661,430.00
Summary
Traumatic Brain Injury (TBI) is the leading cause of disability amongst young adults, many of whom have difficulty walking. Muscle weakness is the main cause of these walking problems, but previous trials have failed to improve walking performance. We have developed new strengthening exercises which focus on how quickly the muscles can contract, rather than just how strong they are. These exercises can increase muscle power by 60-74% and are likely to improve people’s ability to walk.
Improving Postural Stability In People With Parkinson's Disease Using Textured Insoles.
Funder
National Health and Medical Research Council
Funding Amount
$968,538.00
Summary
Falls are a major health and injury problem for people with Parkinson's disease (PD). In this study we propose to undertake a randomised control trial to determine the efficacy of textured insoles to improve postural stability and reduce falls risk in people with Parkinson’s disease. The success of such an inexpensive device would result in improved health outcomes for individuals and large savings in health care through a reduction in fall-related injuries.
Motor Functioning In Young People With Attention Deficit Hyperactivity Disorder – Combined Type: A Three-dimensional Motion Analysis Study.
Funder
National Health and Medical Research Council
Funding Amount
$477,065.00
Summary
Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with AD ....Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with ADHD-CT.Read moreRead less
Identification Of Testis-specific Markers Of Male Infertility
Funder
National Health and Medical Research Council
Funding Amount
$617,008.00
Summary
Infertility affects 1 in 20 men, and carries major health and financial burdens. Patient management is difficult because there are no tests to monitor testicular function. While sperm number is normally used, their absence in the ejaculate provides no information whether sperm are present in the testis suitable for IVF, or if sperm production could be ‘kick-started’ with hormones. Our goal is to identify new markers of testis function in blood, and then use them to help treat infertile men.
Identification And Molecular Characterisation Of High-risk Premalignant Breast Lesions
Funder
National Health and Medical Research Council
Funding Amount
$560,382.00
Summary
Understanding the full repertoire of genetic events that underlie the development of breast cancer may allow development of prevention strategies. This study will analyse genetic data of benign breast lesions that may be non-obligate precursors of breast cancer. Importantly, clinical management of these lesions is difficult. A reliable method of predicting the risk of progression to cancer would be a significant advance, with benefits to individual patients and also the health system.