Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle ....Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle and adipose tissue by stimulating the movement of a glucose transport protein from inside the cell to the cell surface (see http:--www.imb.uq.edu.au-groups-james-glut4 for an animated description of this process). The purpose of this proposal is to dissect the molecular mechanisms by which this glucose transporter can be held inside the cell in the absence of insulin and then allowed to be released from this site moving to the surface in the presence of insulin. Our studies over the past 5 years have brought us much closer to understanding this process in detail. The identification of the molecules responsible for this regulatory step will not only aid our understanding of this process but it will also provide a valuable target for development of therapeutic agents that can be used to combat insulin resistance.Read moreRead less
Macrophages are white blood cells that provide front line defence against infection by initiating inflammatory responses by ingesting or phagocytosing microbes and by releasing soluble messengers (cytokines) to recruit other immune cells. These defensive functions require extensive trafficking of proteins within the macrophages. Protein trafficking is orchestrated in part by a family of membrane fusion proteins called SNAREs. By defining the relevant SNAREs, we have recently discovered a much ac ....Macrophages are white blood cells that provide front line defence against infection by initiating inflammatory responses by ingesting or phagocytosing microbes and by releasing soluble messengers (cytokines) to recruit other immune cells. These defensive functions require extensive trafficking of proteins within the macrophages. Protein trafficking is orchestrated in part by a family of membrane fusion proteins called SNAREs. By defining the relevant SNAREs, we have recently discovered a much acclaimed and novel pathway that allows efficient, combined cytokine secretion and phagocytosis in macrophages. Our studies proposed here will now expand on this discovery by comparing the phagocytic process, in terms of SNARE-mediated membrane and cytokine trafficking, for a wide range of microbes, highlighting differences that could provide new avenues for drug development. Moreover, since our strategy of using SNAREs to investigate and map trafficking pathways has proven so successful, we will now launch a major large-scale initiative to study ALL SNARE-mediated trafficking pathways in macrophages using a discovery pipeline of assays, including live cell imaging, we have developed. This will provide valuable information on many SNAREs including those associated with disease, and will elucidate trafficking pathways governing all macrophage actions in immunity, including cytokine secretion and antigen presentation. All of these pathways are highly relevant to current drug targets being used clinically or studied in inflammatory disease and for the development of vaccines.Read moreRead less
Non-equilibrium presolvation electron processes at the gas-liquid interface. The interaction of low-temperature plasma electrons with liquids has served as a reducing agent in various technological applications in water treatment, agriculture, biofuels and medicine. Predictive control of the plasma-liquid interface is essential to unlocking the potential of these applications, and this has been limited by the absence of the relevant non-equilibrium transport theory describing electrons at the pl ....Non-equilibrium presolvation electron processes at the gas-liquid interface. The interaction of low-temperature plasma electrons with liquids has served as a reducing agent in various technological applications in water treatment, agriculture, biofuels and medicine. Predictive control of the plasma-liquid interface is essential to unlocking the potential of these applications, and this has been limited by the absence of the relevant non-equilibrium transport theory describing electrons at the plasma-liquid interface together with fundamental data describing electron interactions with liquids. The project will develop a state of the art presolvation electron transport model informed by world first measurements of electron cross-sections for radicals and liquids and apply it to model plasma electrochemistry processes.Read moreRead less
Advanced materials for space propulsion: satellites and cubesats. Poorly controlled interactions between plasmas and surfaces often mean loss of process efficiency and surface degradation over time. For Hall thrusters, a type of engine used to move satellites in space, this means increased fuel consumption and shorter useful life. Through modelling and experiment, this project will show how intelligent selection of advanced materials and plasma parameters can minimise surface wear, enable in sit ....Advanced materials for space propulsion: satellites and cubesats. Poorly controlled interactions between plasmas and surfaces often mean loss of process efficiency and surface degradation over time. For Hall thrusters, a type of engine used to move satellites in space, this means increased fuel consumption and shorter useful life. Through modelling and experiment, this project will show how intelligent selection of advanced materials and plasma parameters can minimise surface wear, enable in situ material repair to extend device lifetime, and modulate plasma properties to increase thruster efficiency for a given task. These benefits enable reliable propulsion platforms for massive communication and observation satellite networks and deep space exploration.Read moreRead less
Plasma-assisted on-surface assembly for hydrogen production and beyond. This project aims to discover how to catalyse the formation and control the structure of functional materials with atomic precision using plasmas. New mechanisms of ultra-fast, plasma-catalytic on-surface nanoasembly will translate into energy-efficient, scalable digital fabrication of subnano-cluster and single-atomic-site catalysts over large 3D surface areas, tailored for advanced electrocatalysis. The outcomes including ....Plasma-assisted on-surface assembly for hydrogen production and beyond. This project aims to discover how to catalyse the formation and control the structure of functional materials with atomic precision using plasmas. New mechanisms of ultra-fast, plasma-catalytic on-surface nanoasembly will translate into energy-efficient, scalable digital fabrication of subnano-cluster and single-atomic-site catalysts over large 3D surface areas, tailored for advanced electrocatalysis. The outcomes including new concepts and insights into synergistic action of plasmas and solid surfaces will bridge atomic-scale materials formation and digital fabrication at industrial scales. The benefits including the new nanofabrication platform and clean energy will go beyond the demands of digital manufacturing and hydrogen economy. Read moreRead less
Bright x-ray beams from laser-driven microplasmas. This project aims to develop a new generation of bright, laser-like x-ray sources for laboratory use. X-ray sources underpin key diagnostic techniques in materials science, advancing applications from structural engineering through to ore processing and energy storage. However, the limited brightness of present-day laboratory x-ray sources restricts the utility and range of these diagnostic techniques. This research intends to use intense lasers ....Bright x-ray beams from laser-driven microplasmas. This project aims to develop a new generation of bright, laser-like x-ray sources for laboratory use. X-ray sources underpin key diagnostic techniques in materials science, advancing applications from structural engineering through to ore processing and energy storage. However, the limited brightness of present-day laboratory x-ray sources restricts the utility and range of these diagnostic techniques. This research intends to use intense lasers to create microscopic plasmas and drive high harmonic generation. The high harmonic generation process is already used to create laser-like ultraviolet light. By optimising the characteristics of the plasma medium, the project aims to extend bright high harmonic generation to the x-ray regime.Read moreRead less
Low-temperature plasma processes for high-quality graphene films. The project aims to develop novel plasma-enabled processes for low-cost, energy-efficient, and scalable growth of high-quality graphene films for applications in touch screen, solar cell and other devices. It aims to discover non-equilibrium plasma-surface interactions enabling nucleation and growth of graphene films with large and low-defect domains on metal catalysts at low temperatures, and then develop energy-efficient, enviro ....Low-temperature plasma processes for high-quality graphene films. The project aims to develop novel plasma-enabled processes for low-cost, energy-efficient, and scalable growth of high-quality graphene films for applications in touch screen, solar cell and other devices. It aims to discover non-equilibrium plasma-surface interactions enabling nucleation and growth of graphene films with large and low-defect domains on metal catalysts at low temperatures, and then develop energy-efficient, environment-friendly, and scalable fabrication and device transfer processes. These processes are designed to retain high quality of graphene films upon scale-up and will be compatible with the existing and emerging applications in touch screens and other devices. The expected outcomes include fundamental understanding and novel practical approaches to control synthesis and device integration of two-dimensional atomically-thin materials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102942
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The general Richtmyer-Meshkov instability in magnetohydrodynamics. Fluid dynamic instabilities limit the chance of inertial confinement fusion, a carbon-free process, achieving net energy production. In highly idealised circumstances it has been shown that one of these instabilities can be suppressed by a magnetic field, a phenomenon that this project will investigate in the general case.
The converging shock driven Richtmyer-Meshkov instability in magnetohydrodynamics. Fluid dynamic instabilities limit the chance of inertial confinement fusion, a carbon-free process, achieving net energy production. The project will investigate the effectiveness and consequences of suppressing one of these instabilities with a magnetic field.