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The Role Of Intense Physical Activity In Protecting The Ageing Brain
Funder
National Health and Medical Research Council
Funding Amount
$600,079.00
Summary
Previous research supports the notion that physical activity plays a role in maintaining brain health and preventing Alzheimer’s disease. Nevertheless, the type of activity (i.e. intensity of physical activity) that is of greatest benefit to the brain is yet to be established. This project aims to identify the most beneficial exercise intensity, in terms of brain health, measured utilising brain imaging technology.
Aspirin For The Prevention Of Cognitive Decline In The Elderly: A Neuro-Vascular Imaging Study (ENVIS-ion) From ASPREE
Funder
National Health and Medical Research Council
Funding Amount
$1,341,232.00
Summary
The ENVIS-ion trial will examine whether Aspirin is effective in delaying the onset of worsening of thinking and memory abilities in healthy older adults. Magnetic resonance imaging (MRI) of brain structure will detect markers of early worsening of thinking and memory abilities. Blood vessels in the back of the eye (retina) share many features with vessels in the brain. We will compare whether aspirin lessens changes over time of features shown with brain MRI and retinal photography.
Development Of Microscope-in-a-needle Devices For Improved Clinical Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$327,746.00
Summary
We have developed a new high-resolution optical imaging technology. The unique aspect of our research has been to redesign the imaging probe, miniaturising it to a few hundred microns in diameter, and encase it in a hypodermic needle – a ‘microscope-in-a-needle’. We are developing specific imaging probes to aid in the assessment of lung disease; the diagnosis of liver disease; and integrated into a brain biopsy needle to enable safer brain biopsies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100054
Funder
Australian Research Council
Funding Amount
$824,080.00
Summary
Facility for electric and magnetic probes of materials at extreme conditions. This project aims to establish a readily accessible facility for measurement of electric and magnetic properties of materials under extreme temperature, magnetic field, and sensitivity conditions. The expected outcome is to build capacity for and support world-leading research into novel topological materials, atomically thin materials, materials with strong light-matter interactions and magnetic materials. The benefit ....Facility for electric and magnetic probes of materials at extreme conditions. This project aims to establish a readily accessible facility for measurement of electric and magnetic properties of materials under extreme temperature, magnetic field, and sensitivity conditions. The expected outcome is to build capacity for and support world-leading research into novel topological materials, atomically thin materials, materials with strong light-matter interactions and magnetic materials. The benefits to society are new devices for efficient generation, storage, transmission and switching of energy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100151
Funder
Australian Research Council
Funding Amount
$760,000.00
Summary
Probe and engineer interactions in atomic-scale devices with a LT STM. A low-temperature scanning tunnelling microscope: The project aims to establish a facility to exploit the spectroscopic and spatial resolution of an ultra-low temperature scanning tunnelling microscope in conjunction with atomically controlled dopant engineering. In a variety of experiments the research team will explore ultra-scaled transistors, quantum information science devices, and engineered quantum matter. Improving ou ....Probe and engineer interactions in atomic-scale devices with a LT STM. A low-temperature scanning tunnelling microscope: The project aims to establish a facility to exploit the spectroscopic and spatial resolution of an ultra-low temperature scanning tunnelling microscope in conjunction with atomically controlled dopant engineering. In a variety of experiments the research team will explore ultra-scaled transistors, quantum information science devices, and engineered quantum matter. Improving our ability to investigate semiconductor materials at the atomic scale impacts fields ranging from electronics, telecommunication, quantum information to renewable energy research and puts Australia at the forefront of the field of controlled atomic systems in semiconductors.Read moreRead less
ARC Centre of Excellence for Engineered Quantum Systems. The future of technology lies in controlling the quantum world. The ARC Centre of Excellence for Engineered Quantum Systems (EQuS) will deliver the building blocks of future quantum technologies and, critically, ensure Australian primacy in this endeavour. Three strategic research programs will target Quantum Measurement and Control; Synthetic Quantum Systems and Simulation; and Quantum-Enabled Sensors and Metrology. Within these programs, ....ARC Centre of Excellence for Engineered Quantum Systems. The future of technology lies in controlling the quantum world. The ARC Centre of Excellence for Engineered Quantum Systems (EQuS) will deliver the building blocks of future quantum technologies and, critically, ensure Australian primacy in this endeavour. Three strategic research programs will target Quantum Measurement and Control; Synthetic Quantum Systems and Simulation; and Quantum-Enabled Sensors and Metrology. Within these programs, our Centre will exploit the deepest principles and resources of quantum physics to solve specific problems in engineering, chemistry biology and medicine, stimulating the Australian scientific and engineering communities to exploit (and benefit from) transformative quantum devices.Read moreRead less
Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.