Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100073
Funder
Australian Research Council
Funding Amount
$468,474.00
Summary
Nanoimprint systems: expanding research capability of roll to roll printer. This project aims to strengthen Australian research activities in the development of advanced multifunctional materials through the purchase of thermal and ultraviolet (UV) nano-imprint lithography modules to expand the nanofabrication capacity of roll-to-roll printer line. The various processes used to make nano-sized devices and components fall into two major categories, coating and patterning. Integrating the thermal ....Nanoimprint systems: expanding research capability of roll to roll printer. This project aims to strengthen Australian research activities in the development of advanced multifunctional materials through the purchase of thermal and ultraviolet (UV) nano-imprint lithography modules to expand the nanofabrication capacity of roll-to-roll printer line. The various processes used to make nano-sized devices and components fall into two major categories, coating and patterning. Integrating the thermal and UV nanoimprint lithography modules into the roll-to-roll printer line will provide a unique and simple materials fabrication platform. It will combine coating and nanolithography processes in a low cost, high-throughput and high-resolution format for advanced nanofabrication of microelectronic, telecommunication, biomedical and energy devices.Read moreRead less