New dielectric materials: Improving storage density of high temperature multilayer ceramic capacitors to sustainably meet future energy demands. Electrical energy generation from renewable sources, such as solar, wind and geothermal, provide enormous potential for meeting future energy demands. However, the ability to store and control this energy for miniaturisation and modularisation in applications requiring a wide temperature usage range is a limiting factor that needs to be addressed. This ....New dielectric materials: Improving storage density of high temperature multilayer ceramic capacitors to sustainably meet future energy demands. Electrical energy generation from renewable sources, such as solar, wind and geothermal, provide enormous potential for meeting future energy demands. However, the ability to store and control this energy for miniaturisation and modularisation in applications requiring a wide temperature usage range is a limiting factor that needs to be addressed. This project aims to develop new bismuth-based lead-free dielectric materials for improving the storage density of high temperature multilayer ceramic capacitors for sustainable applications in the energy and vehicle industries, where high temperature stability and high volumetric efficiency are crucial.Read moreRead less
Understanding phenotypes: contributions from studying mutations in a model organism. The distribution of fish across aquatic habitats will be determined jointly by the swimming speed and endurance requirements imposed by features of the environment, such as water flow, and by the swimming capacity of the fish. This project will use zebrafish to characterise how body shape and physiology interact to determine swimming capacity.
Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to c ....Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to contribute to the equitable use of genomic technologies in humans, regardless of geographical origins. Expected outcomes of this research include novel analysis methods and software tools, which should broadly and significantly benefit gene discovery in other species, including those of agricultural relevance.Read moreRead less
A new statistical framework to understand the biological basis of Ankylosing Spondylitis and other complex diseases. Ankylosing Spondylitis (AS) is a highly heritable and common inflammatory arthritis which causes stiffness and progressive fusion of the spine, decreased quality of life and reduced lifespan. There is no known cure for the condition. This project aims to identify genes and biological pathways involved in AS pathogenesis using a new statistical framework that will be applied to tho ....A new statistical framework to understand the biological basis of Ankylosing Spondylitis and other complex diseases. Ankylosing Spondylitis (AS) is a highly heritable and common inflammatory arthritis which causes stiffness and progressive fusion of the spine, decreased quality of life and reduced lifespan. There is no known cure for the condition. This project aims to identify genes and biological pathways involved in AS pathogenesis using a new statistical framework that will be applied to thousands of individuals with the disease. This project will improve understanding of the underlying mechanisms involved in AS pathophysiology, inform development of new drug treatments for the condition, and create a powerful new statistical approach that can be used to identify biological pathways which are important in the pathogenesis of other complex diseases.Read moreRead less
Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and l ....Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and lift productivity by managing innovation for Australia’s industries.Read moreRead less
Genomic Control of Human Complex Trait Variation. This project aims to address knowledge gaps in our understanding of the genetic and environmental control of complex human trait variation. This project will use innovative approaches that combine molecular genomic information with data from large biobank sized cohorts to generate new knowledge of the mechanisms underlying ancestral and sex differences in humans. Expected outcomes include the development of novel methods for the integrative analy ....Genomic Control of Human Complex Trait Variation. This project aims to address knowledge gaps in our understanding of the genetic and environmental control of complex human trait variation. This project will use innovative approaches that combine molecular genomic information with data from large biobank sized cohorts to generate new knowledge of the mechanisms underlying ancestral and sex differences in humans. Expected outcomes include the development of novel methods for the integrative analysis of genomic data and building Australia’s capacity in a highly demanded field, ensuring the capability to realise the translation of this knowledge to positively impact society and human well-being.Read moreRead less
Nanobionic plants. This project aims to develop nanobionic plants as network of semi-permanent sensors capable of rapid, sensitive, selective and unmanned detection and detoxification of chemical warfare agents in aquatic environments and in open air on-site, to allow timely and effective countermeasures. The anticipated goal is to advance the field of advanced manufacturing, environmental change, and nanotechnology with potential to support new national defence capabilities and to value-add Aus ....Nanobionic plants. This project aims to develop nanobionic plants as network of semi-permanent sensors capable of rapid, sensitive, selective and unmanned detection and detoxification of chemical warfare agents in aquatic environments and in open air on-site, to allow timely and effective countermeasures. The anticipated goal is to advance the field of advanced manufacturing, environmental change, and nanotechnology with potential to support new national defence capabilities and to value-add Australian manufacturing industries with innovative, disruptive technologies that lead to achievable opportunities to address its unique needs and to claim Australia’s position within the competitive global manufacturing and defence technology market.Read moreRead less
High-Performance and Evaporative Triboelectric Nanogenerators. This project aims to create high performance triboelectric nanogenerators (TENGs) with outstanding moisture wicking and thermal-moisture stability, while providing a comfortable platform for biomechanical energy harvesting and self-powered sensing. The project expects to generate new knowledge on simultaneous enhancement of output power and moisture management capability of tribo-textiles using interdisciplinary approaches. This shou ....High-Performance and Evaporative Triboelectric Nanogenerators. This project aims to create high performance triboelectric nanogenerators (TENGs) with outstanding moisture wicking and thermal-moisture stability, while providing a comfortable platform for biomechanical energy harvesting and self-powered sensing. The project expects to generate new knowledge on simultaneous enhancement of output power and moisture management capability of tribo-textiles using interdisciplinary approaches. This should overcome the bottleneck of output deterioration of TENGs under humid conditions and provide significant benefits by offering an attractive renewable energy source for driving low power sensors in the era of IoT and opening new opportunities in healthcare, sports, virtual reality and smart homes.
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Developing methods for the analysis of massively parallel sequencing data in family studies. This project will develop analytical methods to use the latest, high-throughput method of generating sequencing data, i.e. the letters of the human genome alphabet. These tools will be used to identify the causal mutations in families with inherited disorders, leading to diagnostic tests for these families.
Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses. Attention deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in children; while treatments are available they are ineffective for many patients. This project will develop methods for predicting genetic effects at the level of the biological mechanism to assist in identifying new drug targets and behavioural interventions.