Engineered Polymer Scaffolds for Controlled Proliferation and Differentiation of Stem Cells. This project aims to develop a new methodology to sculpt 3D polymer scaffolds coated with cell adhesion and growth factors to control environmental cues, for the first time rapidly generating large quantities of undifferentiated stem cells. This project aims to exponentially increase cell generation in order to finally be able to unlock the potential of stem cells for application in regenerative medicine ....Engineered Polymer Scaffolds for Controlled Proliferation and Differentiation of Stem Cells. This project aims to develop a new methodology to sculpt 3D polymer scaffolds coated with cell adhesion and growth factors to control environmental cues, for the first time rapidly generating large quantities of undifferentiated stem cells. This project aims to exponentially increase cell generation in order to finally be able to unlock the potential of stem cells for application in regenerative medicine. The resulting cell repositories could make a significant contribution to human health outcomes.Read moreRead less
Bioengineered bioscaffolds for Achilles tendinopathy treatment. The purpose of the project is to improve outcomes following the surgical treatment of Achilles tendinopathy. The expected outcome is the development in animals of new ways to design tissue engineered bioscaffolds for the surgical repair of Achilles tendinopathy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100012
Funder
Australian Research Council
Funding Amount
$890,000.00
Summary
Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will ....Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will effectively provide the biologist with the ability to develop the complete correlative picture of organelles and cells. The instrument will also provide a much needed resource for researchers across disciplines such as physics, chemistry, biology, geology and engineering.Read moreRead less
Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population a ....Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population and people with bone abnormalities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101308
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
An in vitro model of biomaterial-induced thrombosis. This project intends to use bioengineering strategies to develop new methods to understand material interactions with proteins and cells. The project plans to develop microfluidic channels to contain test materials and immobilise a key enzyme associated with thrombosis by plasma immersion ion implantation. This knowledge may increase our understanding of material-biomolecule interactions and have implications for manipulating biological foulin ....An in vitro model of biomaterial-induced thrombosis. This project intends to use bioengineering strategies to develop new methods to understand material interactions with proteins and cells. The project plans to develop microfluidic channels to contain test materials and immobilise a key enzyme associated with thrombosis by plasma immersion ion implantation. This knowledge may increase our understanding of material-biomolecule interactions and have implications for manipulating biological fouling across multiple fields.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100115
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploi ....High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploit interfacial phenomena and to tailor processing-microstructure-composition correlations, so as to design new materials with the best performance possible. Probes with unique capabilities will measure surface morphology, optical properties, elemental composition and crystallographic phase.The facility will be the first in Australia to offer a comprehensive study of structure and properties at high temperature.Read moreRead less
Highly ordered and tunable extracellular DNA micro- and nanopatterns for investigating the attachment mechanisms of pseudomonas aeruginosa to surfaces. Preventing infectious bacteria from colonising artificial surfaces is a major scientific challenge. New engineered surfaces will be designed to better understand how the important pathogen Pseudomonas aeruginosa sticks to surfaces, facilitating new ways of reducing infections acquired from the surface of, for example, medical devices.
Discovery Early Career Researcher Award - Grant ID: DE130101550
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Functional polymer encapsulation to enhance biological performance of implantable materials. This project will develop biomaterial films from essential oils using a low-cost 'green' technology. Applied to commercial biomaterials, these films will minimise infections and inflammations commonly associated with implants. These films will also enable clinical use of metallic resorbable implants for tissue engineering and function restoration.
Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release ....Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release is triggered by an electric potential and drug transport is controlled by means of sonophoresis. The main advantage of drug delivery via sonophoresis is elimination of risks associated with injections such as infection and damage to local tissue, and elimination of patient discomfort, pain and fear.Read moreRead less
Elucidating surface-mediated permissive cues for cellular differentiation. This project will develop a novel biomaterial platform technology that will enable firstly the probing and thereafter the control of the cellular pathways of adult mesenchymal stem cells. These fundamental insights will be translated into novel stem cell culture ware products that will enable clinically relevant, functional tissue repair and regeneration.