Visualisation Of Functionally Activated Circuitry In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$347,036.00
Summary
We are seeking to develop a method to precisely determine which parts of the brain are involved in the carrying out of different brain functions. The main advantage of our new method will be that we will be able to directly visualise the circuitry involved in a specified brain function. The brain is like a vast computer, with literally billions of connections between different parts, and it is these connections which are used to form functional circuits, which ultimately result in the brain cont ....We are seeking to develop a method to precisely determine which parts of the brain are involved in the carrying out of different brain functions. The main advantage of our new method will be that we will be able to directly visualise the circuitry involved in a specified brain function. The brain is like a vast computer, with literally billions of connections between different parts, and it is these connections which are used to form functional circuits, which ultimately result in the brain control of bodily function. Up until now, there has been no direct way of being able to directly visualise which of those billions of connections are involved in the formation of a circuit for any particular brain function. We plan to use a genetic approach to help to visualise functionally activated brain circuits. We know that some genes are turned on in the nerve cells which are activated during a brain function. We will use this knowledge to generate a new line of genetically engineered mice. In these mice, the genes which are turned on during brain activation will in turn be used to turn on special markers which will light up the activated circuits. This will be of great signficance in our understanding of brain function. It should also help us to understand what happens to these circuits in different diseases of the brain, such as following stroke, in senility, and Alzheimer's disease.Read moreRead less
Thermoelectric devices for high-performing localised coolers. This project aims to develop a lightweight, low-energy-consumption, and high-durability wearable thermoelectric cooler for localised cooling using a novel industry-led approach, coupled with device design and materials engineering strategies. The key breakthrough expected is to design wearable thermoelectric coolers by using flexible substrates and thermoelectric materials with engineered chemistry and unique structures for achieving ....Thermoelectric devices for high-performing localised coolers. This project aims to develop a lightweight, low-energy-consumption, and high-durability wearable thermoelectric cooler for localised cooling using a novel industry-led approach, coupled with device design and materials engineering strategies. The key breakthrough expected is to design wearable thermoelectric coolers by using flexible substrates and thermoelectric materials with engineered chemistry and unique structures for achieving localised, instant, and controllable cooling with super low power input for personal usage in building and mining industry. Expected outcomes include innovative technologies for achieving high-efficiency cooling, which will provide significant economic and commercial benefits for Australia.Read moreRead less
Mapping And Restoring Brain Networks Underpinning Psychiatric Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
My research investigates how networks of brain regions dynamically communicate to support human behavior. I am interested in how brain network activity deviates from the norm to give rise to psychiatric symptoms. Results from my work will facilitate targeted research and interventions aimed at treating symptoms of psychiatric disorders.
Long Term Outcome From Early Childhood Brain Injury: 10 Year Follow Up
Funder
National Health and Medical Research Council
Funding Amount
$338,900.00
Summary
The primary aim of this project is to further improve our understanding of the long-term consequences of childhood traumatic brain injury (TBI). Over the past decade our research team has ascertained a sample of children sustaining TBI, and systematically followed their progress over a 5-year period. The project has an international reputation, and is unique in terms of length of follow-up, prospective design and representative, well-maintained sample. Our findings challenge the traditionally he ....The primary aim of this project is to further improve our understanding of the long-term consequences of childhood traumatic brain injury (TBI). Over the past decade our research team has ascertained a sample of children sustaining TBI, and systematically followed their progress over a 5-year period. The project has an international reputation, and is unique in terms of length of follow-up, prospective design and representative, well-maintained sample. Our findings challenge the traditionally held view that children are resilient and recover fully from early brain insult. Rather, we have shown that, up to 5 years post-TBI, many children experience impairments in physical, cognitive and behavioural function. These impairments result in educational, vocational, social and emotional problems, limiting the child's capacity to meet developmental expectations and achieve adequate quality of life. The implication is that these problems will lead to life-long disability, resulting in high levels of individual, family and community burden. However, with follow-up data limited to 5 years, there remains a possibility that ongoing developmental processes may support an extended recovery period in childhood TBI, in comparison to the 2-year period cited in adult models. The review of this sample, 10 years post-injury, provides an unprecedented opportunity to address this possibility and to document recovery-outcome as children move into adolescence and adulthood. Not all children experience problems post-injury. However, predicting individual outcome remains a significant challenge, with particular clinical relevance to treatment and follow-up. Thus, the second aim of the proposed study is to examine factors that contribute to recovery and outcome.Read moreRead less
Thin combinatorial films for heat management in microelectronics. This project aims to provide a viable solution for heat management in microelectronics by using highly efficient Peltier devices made with thin combinatorial films. Heat generated by electric current, which is ubiquitous in microelectronic devices, has become increasingly problematic for high density charge-based logical circuitries. The project will significantly enhance the energy conversion efficiency of Peltier devices by opti ....Thin combinatorial films for heat management in microelectronics. This project aims to provide a viable solution for heat management in microelectronics by using highly efficient Peltier devices made with thin combinatorial films. Heat generated by electric current, which is ubiquitous in microelectronic devices, has become increasingly problematic for high density charge-based logical circuitries. The project will significantly enhance the energy conversion efficiency of Peltier devices by optimising the interdependent electron and phonon transports, simultaneously, with a new concept of thin combinatorial films for heat management in microelectronic devices. This is expected to facilitate the development of novel materials in Australia, with access to a large global market.Read moreRead less
Synthesis, characterisation, and applications of atomically thin layers of transition metal oxides and dichalcogenides. The project will explore the key fundamental properties of atomically-thin layers of functional materials made of transition metal oxides and dichalcogenides. By reducing the thickness of these materials to only a few atomic layers, the project will create novel electronic properties that are otherwise not exhibited. The aims are to understand layer-dependent changes to their p ....Synthesis, characterisation, and applications of atomically thin layers of transition metal oxides and dichalcogenides. The project will explore the key fundamental properties of atomically-thin layers of functional materials made of transition metal oxides and dichalcogenides. By reducing the thickness of these materials to only a few atomic layers, the project will create novel electronic properties that are otherwise not exhibited. The aims are to understand layer-dependent changes to their physical and chemical properties; to control and tune such properties by altering crystal structure and composition; and to investigate the effect of mixed-layer heterostructure configurations on these characteristics. The fundamental insights gained will serve as the driver for the next generation nanotechnology-enabled electronics and sensing systems.Read moreRead less