Brainstem And Hypothalamic Function And Anatomy In Migraine
Funder
National Health and Medical Research Council
Funding Amount
$652,828.00
Summary
Migraine is a disabling condition characterized by mostly unilateral throbbing head pain and a range of associated neurological symptoms. The underlying mechanisms responsible for the initiation of migraine remains unknown. We aim to determine brain anatomy and activity patterns in migraineurs throughout the migraine cycle. An understanding of the mechanisms responsible for migraine will aid in better treatment development.
Do People With Severe Traumatic Brain Injury Benefit From Making Errors? A Clinical Trial Of The Efficacy Of Error-based Learning And Errorless Learning Training
Funder
National Health and Medical Research Council
Funding Amount
$579,142.00
Summary
People with severe traumatic brain injury (TBI) have trouble recognising changes in their abilities and often fail to notice mistakes on daily tasks. Although people can learn strategies, these are rarely used as needed in daily life. This study will determine whether people with severe TBI become more self-aware and able to transfer what they learn when they are made aware of their errors, as compared to when other people prevent them from making errors. The findings will have major implication ....People with severe traumatic brain injury (TBI) have trouble recognising changes in their abilities and often fail to notice mistakes on daily tasks. Although people can learn strategies, these are rarely used as needed in daily life. This study will determine whether people with severe TBI become more self-aware and able to transfer what they learn when they are made aware of their errors, as compared to when other people prevent them from making errors. The findings will have major implications for rehabilitation of neurological disorders.Read moreRead less
High-resolution Brain Imaging Of Basal Ganglia Function
Funder
National Health and Medical Research Council
Funding Amount
$589,083.00
Summary
This project will develop new methods for high resolution MRI imaging of the human brain. We will assess functions of deep brain areas known as the basal ganglia that play a critical role in movement planning and co-ordination. Dysfunction within the basal ganglia is responsible for the motor impairments seen in people with Parkinson’s disease. In this project, we will examine changes in basal ganglia function and structure that lead to individual differences in movement control and learning.
Activity In Central Cough Networks In Patients With Cough Hypersensitivity
Funder
National Health and Medical Research Council
Funding Amount
$459,499.00
Summary
Excessive cough associated with an airways disease represents the most common reason for doctor consultations. However, the current therapeutic options for relieving excessive cough are limited. This proposal will provide unprecedented insights into the brain mechanisms that contribute to the development of cough disorders in airways disease.
Mechanisms Of PTEN Regulation By Ndfip1 And Their Biological Consequences For Neuron Survival During Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$686,640.00
Summary
We have discovered a new protein (Ndfip1) that protects brain cells from death after brain injury from trauma and stroke. We will investigate why this protein is activated only in some, but not in other, brain cells after injury. In this application, we will study the mechanisms behind neuron protection, and use this information to explore how to increase the number of brain cells activating Ndfip1.
This study investigates how much an individual's genes and environment account for the wide variation in brain structure and function. Using brain imaging we examine in what way the connectivity of the brain of identical and non-identical twins is the same or different from that of their co-twin, and carry out analysis of their DNA to identify some of the genes involved. This will provide fundamental information on genetic mechanisms influencing variation in brain structure and function.
Social Functioning In Early Primary School Following Traumatic Brain Injury Prior To Age Three: The Contribution Of Cognitive, Environmental And Neurological Factors
Funder
National Health and Medical Research Council
Funding Amount
$394,501.00
Summary
Children of preschool age and older demonstrate social problems after a traumatic brain injury (TBI). What effect a TBI has on the social function of young children (before 3 years) is currently unknown but is thought that these children have more problems than older children do. This study will look at how a TBI impacts on the social function of young children and the role of cognition and brain development in social function will also be explored.
Quantifying The Role Of Epigenetic Factors In Neurocognitive Outcomes: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$1,516,790.00
Summary
We aim to identify the environmental factors in early life that contribute towards an individual brain development using MRI brain scans and related psychological skills measured in late childhood. We are using twins to better understand differences in their early life environments independent of genetics.
Central Nervous Pathways For The Sympathetic Control Of Immune Function
Funder
National Health and Medical Research Council
Funding Amount
$300,741.00
Summary
The nervous system regulates immune system function by a special set of nerves that are part of the sympathetic nervous system. This project aims to work out which brain pathways control them.
Understanding The Mechanisms Of Development And Treatment In Hydrocephalus.
Funder
National Health and Medical Research Council
Funding Amount
$395,914.00
Summary
This project aims to investigate the progressive change in cerebrospinal fluid dynamics, axonal damage and tissue mechanical properties during the development and treatment of hydrocephalus in-vivo. Results from this study is important to elucidate the mechanisms of hydrocephalus and to improve treatment and diagnosis of hydrocephalus.