Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989859
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistr ....A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistry, research supported by this instrumentation will provide Australians with improvements to their dental health. Furthermore applications to industrial materials are providing Australian industries with better characterisation of their products that is leading to improved export performance and consequent improvement in Australia's balance of trade.Read moreRead less
Neurotrophic factors for pelvic autonomic neurons: the role of neurturin. This project is about pelvic parasympathetic neurons, which are responsible for involuntary activities such as bladder voiding and penile erection. We are interested in the neurotrophic factors that determine survival of these neurons during early mammalian development and keep them healthy in adults. Little is known about ?parasympathetic neurotrophic factors? in general. However we have recently discovered that the prote ....Neurotrophic factors for pelvic autonomic neurons: the role of neurturin. This project is about pelvic parasympathetic neurons, which are responsible for involuntary activities such as bladder voiding and penile erection. We are interested in the neurotrophic factors that determine survival of these neurons during early mammalian development and keep them healthy in adults. Little is known about ?parasympathetic neurotrophic factors? in general. However we have recently discovered that the protein neurturin is very important in the pelvic parasympathetic system. We will determine exactly how neurturin affects pelvic neurons and how it interacts with other neurotrophic factors. Our results will fill a major gap in our knowledge of fundamental neurobiology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775598
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
High-Resolution Transmission Electron Tomographic Facility for Nanoanalytical Characterisation in the Life and Material Sciences. The requested instrument will allow researchers in New South Wales to (i) visualize biological and physical samples in three-dimensions by electron tomography and modeling and (ii) image samples in a near-natural state and at high-resolution by cryogenic techniques. This essential research platform will provide novel information that faithfully presents both the surfa ....High-Resolution Transmission Electron Tomographic Facility for Nanoanalytical Characterisation in the Life and Material Sciences. The requested instrument will allow researchers in New South Wales to (i) visualize biological and physical samples in three-dimensions by electron tomography and modeling and (ii) image samples in a near-natural state and at high-resolution by cryogenic techniques. This essential research platform will provide novel information that faithfully presents both the surface and internal structure of samples down to the nanometre scale, enabling structural research to the highest scientific standards. The resulting knowledge is essential to diverse areas that range from development of cures to diabetes and cancer to creation of environmentally-friendly industrial catalysts to design of new nanoparticles and biosensors.Read moreRead less
Specification and evolution of vertebrate appendicular muscle. Previously we have determined that two different developmental mechanisms are utilised to make the muscles present within the fins and limbs of distinct vertebrate species. This proposal is concerned with determining the morphogenetic, evolutionary and molecular basis for these two different developmental modes. To do this we will to extend our observations more widely to examine muscle formation in both the paired fins in a phyloge ....Specification and evolution of vertebrate appendicular muscle. Previously we have determined that two different developmental mechanisms are utilised to make the muscles present within the fins and limbs of distinct vertebrate species. This proposal is concerned with determining the morphogenetic, evolutionary and molecular basis for these two different developmental modes. To do this we will to extend our observations more widely to examine muscle formation in both the paired fins in a phylogenetically diverse context. We further hope to determine the underlying genetic basis for these different morphologies by developing techniques to examine their formation in a number of embryonic contexts.Read moreRead less
Catalytic production of health food additives from crustacean wastes. Cost-effective production of new synthetic amino acids as value-added food additives from crustacean wastes is vital for waste recycling and a sustainable economy. This project will develop a unique catalytic system for the selective conversion of waste-derived compounds into tailor-made products. Advanced in situ spectroscopic techniques will be employed to establish the structure-reactivity relationship of working catalysts ....Catalytic production of health food additives from crustacean wastes. Cost-effective production of new synthetic amino acids as value-added food additives from crustacean wastes is vital for waste recycling and a sustainable economy. This project will develop a unique catalytic system for the selective conversion of waste-derived compounds into tailor-made products. Advanced in situ spectroscopic techniques will be employed to establish the structure-reactivity relationship of working catalysts and thereby manipulate the key factors governing the activity/selectivity. Such cutting-edge knowledge gained is crucial for optimising process effciency and resource utilisation, which is essential for the success of the biorefining industry and a more environmentally-friendly chemical and food economy in Australia.Read moreRead less
Structure and states of operator-algebraic dynamical systems. This project is in the general area of functional analysis, and more specifically operator theory, an area in which the University of Wollongong has an active research group and a strong international reputation. The investigators will study dynamical systems arising in combinatorial and number-theoretic situations, where the analogue of the "dynamics'' is provided by an action of the real line on an operator algebra. Thus the project ....Structure and states of operator-algebraic dynamical systems. This project is in the general area of functional analysis, and more specifically operator theory, an area in which the University of Wollongong has an active research group and a strong international reputation. The investigators will study dynamical systems arising in combinatorial and number-theoretic situations, where the analogue of the "dynamics'' is provided by an action of the real line on an operator algebra. Thus the project will involve ideas and techniques from a wide range of mathematical disciplines, and will help to broaden Australia's expertise across these disciplines.Read moreRead less
Endomorphisms, transfer operators and Hilbert modules. This project is in the general area of functional analysis, an area where both Newcastle University and the University of New South Wales have strong international reputations. The aim of the project is to study irreversible dynamics in the presence of transfer operators, as recently introduced by Professor Exel. The motivation comes from a variety of examples arising in different areas of mathematics, including number theory and graph theor ....Endomorphisms, transfer operators and Hilbert modules. This project is in the general area of functional analysis, an area where both Newcastle University and the University of New South Wales have strong international reputations. The aim of the project is to study irreversible dynamics in the presence of transfer operators, as recently introduced by Professor Exel. The motivation comes from a variety of examples arising in different areas of mathematics, including number theory and graph theory. It is hoped that the results will give new understanding of the algebraic and analytic structure underlying the multi-resolution analyses used in approximation theory and Fourier analysis. This project will help ensure that Australia has a strong foundation in mathematics which will foster innovation.Read moreRead less
Representations of dynamical systems, amenability, and proper actions. Mathematicians study abstract objects by representing them in terms of well-understood concrete models, and need to know when a representation is faithful, in the sense that the model contains complete information. Dynamical systems are an abstraction of physical systems suitable for studying time evolution and symmetries. The project aims to determine when important representations of dynamical systems are faithful, or, in ....Representations of dynamical systems, amenability, and proper actions. Mathematicians study abstract objects by representing them in terms of well-understood concrete models, and need to know when a representation is faithful, in the sense that the model contains complete information. Dynamical systems are an abstraction of physical systems suitable for studying time evolution and symmetries. The project aims to determine when important representations of dynamical systems are faithful, or, in mathematical language, when the dynamical system is amenable. The proposed strategy involves extending Rieffel's notion of proper actions; the construction should be of wide applicability apart from the intended applications to amenability.Read moreRead less
Operator algebras associated to semigroups and graphs. This project aims to unify ideas from two highly topical areas of mathematics in which one studies discrete objects by representing them as families of linear transformations. In the first area, one represents the semigroups which model irreversible dynamics as isometries (that is, distance-preserving transformations); in the second, one represents networks by families of partially defined isometries in a way which reflects the behaviour of ....Operator algebras associated to semigroups and graphs. This project aims to unify ideas from two highly topical areas of mathematics in which one studies discrete objects by representing them as families of linear transformations. In the first area, one represents the semigroups which model irreversible dynamics as isometries (that is, distance-preserving transformations); in the second, one represents networks by families of partially defined isometries in a way which reflects the behaviour of paths in the network. The link will be achieved by viewing the operator algebras they generate as semidirect products which have been twisted by a noncommutative cocycle.Read moreRead less