Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Developing a disability policy model to target the prevention or reduction of limitations on functioning and wellbeing. With the ageing of Australian society the challenge for public health is shifting from preventing death and disease onset to supporting healthy and productive ageing. The disability policy model will allow cost-effective targeting of interventions to reduce or prevent onset of disability or reduce its severity particularly among older Australians.
Development of a novel best approximation theory with applications . The aim of this project is to develop an innovative best approximation theory for complex fractional boundary value problems with discontinuities and with no compactness, and then apply the theory to study two classes of complex partial differential equation boundary value problems with industrial applications. The work will lead to the development of a new theory and a suite of innovative analytical and computational methods f ....Development of a novel best approximation theory with applications . The aim of this project is to develop an innovative best approximation theory for complex fractional boundary value problems with discontinuities and with no compactness, and then apply the theory to study two classes of complex partial differential equation boundary value problems with industrial applications. The work will lead to the development of a new theory and a suite of innovative analytical and computational methods for solving a wide range of nonlinear problems with singularities and non-local properties. The expected outcomes of the project will significantly advance our methods for the modelling and control of many industrial systems and processes.
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Novel nonlinear functional analysis methods for singular and impulsive boundary value problems. This project aims to develop innovative functional analysis theories and methods to study various complex nonlinear boundary value problems, with particular focus on singular and impulsive problems. The outcomes of this project aims to enhance Australia’s capability of tackling complex nonlinear science and engineering problems using sophisticated mathematical methods. This project aims to also provid ....Novel nonlinear functional analysis methods for singular and impulsive boundary value problems. This project aims to develop innovative functional analysis theories and methods to study various complex nonlinear boundary value problems, with particular focus on singular and impulsive problems. The outcomes of this project aims to enhance Australia’s capability of tackling complex nonlinear science and engineering problems using sophisticated mathematical methods. This project aims to also provide engineers and scientists with a theoretical base and simulation technique for the study and optimal control of impulsive systems and processes involving nonlinear singularity.Read moreRead less
The Role Of Intense Physical Activity In Protecting The Ageing Brain
Funder
National Health and Medical Research Council
Funding Amount
$600,079.00
Summary
Previous research supports the notion that physical activity plays a role in maintaining brain health and preventing Alzheimer’s disease. Nevertheless, the type of activity (i.e. intensity of physical activity) that is of greatest benefit to the brain is yet to be established. This project aims to identify the most beneficial exercise intensity, in terms of brain health, measured utilising brain imaging technology.
Nonlinear spatial and spatiotemporal econometrics: theory with applications. Modern societies like Australia have major challenges in the forecasting, measuring and managing of risks associated with global economic and environmental/climate changes. These tasks require advanced econometric techniques in modelling and forecasting of complex nonlinear spatiotemporal variability in economic and social systems. This project will develop frontier econometric technologies that enable more accurate eco ....Nonlinear spatial and spatiotemporal econometrics: theory with applications. Modern societies like Australia have major challenges in the forecasting, measuring and managing of risks associated with global economic and environmental/climate changes. These tasks require advanced econometric techniques in modelling and forecasting of complex nonlinear spatiotemporal variability in economic and social systems. This project will develop frontier econometric technologies that enable more accurate economic and climate forecasts. The tools produced will provide Australia's scientists and policy-makers with a greater capacity to manage the risks associated with these challenges. A side-benefit of the research will be high-quality publications that enhance the nation's reputation in this cutting edge research.Read moreRead less
CO2 Utilisation for Energy Storage. This project aims to develop a novel technology that can convert carbon dioxide into useful products while storing intermittent renewable energy as green stable chemical energy. The project plans to focus on the development of a robust cathode for the conversion of carbon dioxide with optimum physical and chemical structure to achieve long-term stable performance. This technology would make a significant contribution to increasing the proportion of renewable e ....CO2 Utilisation for Energy Storage. This project aims to develop a novel technology that can convert carbon dioxide into useful products while storing intermittent renewable energy as green stable chemical energy. The project plans to focus on the development of a robust cathode for the conversion of carbon dioxide with optimum physical and chemical structure to achieve long-term stable performance. This technology would make a significant contribution to increasing the proportion of renewable energy in our energy supply and reducing our carbon dioxide emissions.Read moreRead less
Development of nanoporous materials for capture and release of oxygen. This project aims to develop new materials to make lighter, more efficient oxygen concentrators. The project will combine materials that can capture oxygen with particles that can be magnetically heated, making it possible to release the oxygen rapidly and efficiently when needed. Expected outcomes from this project include new composite materials and better understanding of how gases are trapped and released within composite ....Development of nanoporous materials for capture and release of oxygen. This project aims to develop new materials to make lighter, more efficient oxygen concentrators. The project will combine materials that can capture oxygen with particles that can be magnetically heated, making it possible to release the oxygen rapidly and efficiently when needed. Expected outcomes from this project include new composite materials and better understanding of how gases are trapped and released within composite materials. Benefits from this project may include oxygen concentrators that are more portable and have longer battery life, both with industrial and medical applications.Read moreRead less