Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Ex ....Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.Read moreRead less
Next generation core-shell materials based on biomolecular dual-templating. This project aims to discover and develop new methods and knowledge for the precision engineering of next-generation core-shell materials using sustainable biomolecular dual-templating processes. This research builds on a recent breakthrough - emulsion and biomimetic dual-templating technology for facile preparation of silica capsules, and is expected to revolutionise current approaches for making core-shell materials. S ....Next generation core-shell materials based on biomolecular dual-templating. This project aims to discover and develop new methods and knowledge for the precision engineering of next-generation core-shell materials using sustainable biomolecular dual-templating processes. This research builds on a recent breakthrough - emulsion and biomimetic dual-templating technology for facile preparation of silica capsules, and is expected to revolutionise current approaches for making core-shell materials. Significant outcomes are expected to be achieved through building fundamental understanding around this breakthrough, including new concepts for hierarchical nanomaterials based on biomolecular design, new molecular and engineering design rules for core-shell materials, and novel materials for applications in sustained release and delivery systems.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Engineered nanoporous materials and composites having hierarchical structures by emulsion templating. The project aims to develop new and flexible emulsion-templated processes capable of constructing novel nanoporous materials with hierarchical structures. The project has the potential to revolutionise current approaches for making porous materials, and the outcomes will enhance Australia's ability in frontier technologies and advanced materials.